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Literature summary extracted from

  • Wikvall, K.
    Hydroxylations in biosynthesis of bile acids. Isolation of a cytochrome P-450 from rabbit liver mitochondria catalyzing 26-hydroxylation of C27-steroids (1984), J. Biol. Chem., 259, 3800-3804.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.15.15 mitochondrion
-
 Oryctolagus cuniculus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.15.15 5-cholestene-3beta,7alpha-diol + reduced adrenodoxin + O2 Oryctolagus cuniculus
-
 5-cholestene-3alpha,7alpha,26-triol + oxidized adrenodoxin + H2O
-
 ?
1.14.15.15 5beta-cholestane-3alpha,7alpha,12alpha-triol + reduced adrenodoxin + O2 Oryctolagus cuniculus
-
 5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol + oxidized adrenodoxin + H2O
-
 ?
1.14.15.15 5beta-cholestane-3alpha,7alpha-diol + reduced adrenodoxin + O2 Oryctolagus cuniculus
-
 5beta-cholestane-3alpha,7alpha,26-triol + oxidized adrenodoxin + H2O
-
 ?
1.14.15.15 7alpha-hydroxy-4-cholesten-3-one + reduced adrenodoxin + O2 Oryctolagus cuniculus
-
 7alpha,26-dihydroxy-4-cholesten-3-one + oxidized adrenodoxin + H2O
-
 ?
1.14.15.15 cholesterol + reduced adrenodoxin + H+ + O2 Oryctolagus cuniculus
-
 26-hydroxycholesterol + oxidized adrenodoxin + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.15.15 Oryctolagus cuniculus
-
 male New Zealand White rabbits
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.15.15 liver
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.15.15 5-cholestene-3beta,7alpha-diol + reduced adrenodoxin + O2
-
 Oryctolagus cuniculus 5-cholestene-3alpha,7alpha,26-triol + oxidized adrenodoxin + H2O
-
 ?
1.14.15.15 5beta-cholestane-3alpha,7alpha,12alpha-triol + reduced adrenodoxin + O2
-
 Oryctolagus cuniculus 5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol + oxidized adrenodoxin + H2O
-
 ?
1.14.15.15 5beta-cholestane-3alpha,7alpha-diol + reduced adrenodoxin + O2
-
 Oryctolagus cuniculus 5beta-cholestane-3alpha,7alpha,26-triol + oxidized adrenodoxin + H2O
-
 ?
1.14.15.15 7alpha-hydroxy-4-cholesten-3-one + reduced adrenodoxin + O2
-
 Oryctolagus cuniculus 7alpha,26-dihydroxy-4-cholesten-3-one + oxidized adrenodoxin + H2O
-
 ?
1.14.15.15 cholesterol + reduced adrenodoxin + H+ + O2
-
 Oryctolagus cuniculus 26-hydroxycholesterol + oxidized adrenodoxin + H2O
-
 ?
1.14.15.15 additional information the enzyme does not perform 7alpha-, 12alpha-, or 25-hydroxylations on C27-steroids Oryctolagus cuniculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.15.15 CYP27A
-
 Oryctolagus cuniculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.14.15.15 7.4
-
 assay at Oryctolagus cuniculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.15.15 Ferredoxin
-
 Oryctolagus cuniculus
1.14.15.15 NADPH
-
 Oryctolagus cuniculus