EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.91 | cardiolipin | - |
Homo sapiens | |
2.7.1.91 | additional information | not affected by bovine serum albumin | Homo sapiens | |
2.7.1.91 | additional information | not stimulated by phosphatidylcholine or phosphatidylethanolamine | Homo sapiens | |
2.7.1.91 | phosphatidic acid | - |
Homo sapiens | |
2.7.1.91 | phosphatidylinositol | - |
Homo sapiens | |
2.7.1.91 | phosphatidylinositol bisphosphate | - |
Homo sapiens | |
2.7.1.91 | phosphatidylserine | - |
Homo sapiens | |
2.7.1.91 | Triton X-100 | - |
Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.91 | bovine serum albumin | - |
Homo sapiens | |
2.7.1.91 | Cu2+ | - |
Homo sapiens | |
2.7.1.91 | dimethylsphingosine | noncompetitive inhibitor | Homo sapiens | |
2.7.1.91 | DL-threo-dihydrosphinganine | competitive inhibitor | Homo sapiens | |
2.7.1.91 | DL-threo-dihydrosphingosine | competitive inhibitor | Homo sapiens | |
2.7.1.91 | Fe2+ | - |
Homo sapiens | |
2.7.1.91 | KCl | increasing KCl concentration profoundly inhibits activity | Homo sapiens | |
2.7.1.91 | NaCl | increasing NaCl concentration profoundly inhibits activity | Homo sapiens | |
2.7.1.91 | Triton X-100 | - |
Homo sapiens | |
2.7.1.91 | Zn2+ | - |
Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.1.91 | 0.005 | - |
sphingosine | - |
Rattus norvegicus | |
2.7.1.91 | 0.0138 | - |
sphingosine | - |
Homo sapiens | |
2.7.1.91 | 0.0156 | - |
sphingosine | - |
Homo sapiens | |
2.7.1.91 | 0.07 | 0.1 | ATP | - |
Homo sapiens | |
2.7.1.91 | 0.093 | - |
ATP | - |
Rattus norvegicus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.7.1.91 | cytosol | - |
Homo sapiens | 5829 | - |
2.7.1.91 | cytosol | - |
Rattus norvegicus | 5829 | - |
2.7.1.91 | nucleus | - |
Homo sapiens | 5634 | - |
2.7.1.91 | nucleus | - |
Rattus norvegicus | 5634 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.91 | K+ | increasing KCl concentration stimulates activity | Homo sapiens | |
2.7.1.91 | Mg2+ | highest activity in the presence of Mg2+ | Homo sapiens | |
2.7.1.91 | Mn2+ | - |
Homo sapiens | |
2.7.1.91 | Na+ | increasing NaCl concentration stimulates activity | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.1.91 | Homo sapiens | Q9NRA0 | - |
- |
2.7.1.91 | Homo sapiens | Q9NYA1 | - |
- |
2.7.1.91 | Rattus norvegicus | Q91V26 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.1.91 | brain | - |
Rattus norvegicus | - |
2.7.1.91 | heart | - |
Rattus norvegicus | - |
2.7.1.91 | kidney | - |
Rattus norvegicus | - |
2.7.1.91 | liver | - |
Rattus norvegicus | - |
2.7.1.91 | lung | - |
Rattus norvegicus | - |
2.7.1.91 | platelet | - |
Homo sapiens | - |
2.7.1.91 | spleen | - |
Rattus norvegicus | - |
2.7.1.91 | thymus | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.91 | ATP + DL-threo-dihydrosphingosine | - |
Homo sapiens | ADP + DL-threo-dihydrosphingosine 1-phosphate | - |
? | |
2.7.1.91 | ATP + FTY720 | - |
Homo sapiens | ADP + ? | - |
? | |
2.7.1.91 | ATP + phytosphingosine | - |
Homo sapiens | ADP + phytosphingosine 1-phosphate | - |
? | |
2.7.1.91 | ATP + sphinganine | - |
Homo sapiens | ADP + sphinganine 1-phosphate | - |
? | |
2.7.1.91 | ATP + sphinganine | SK2 has a higher substrate affinity to sphinganine than to sphingosine | Homo sapiens | ADP + sphinganine 1-phosphate | - |
? | |
2.7.1.91 | ATP + sphingosine | - |
Homo sapiens | ADP + sphingosine 1-phosphate | - |
? | |
2.7.1.91 | ATP + sphingosine | - |
Rattus norvegicus | ADP + sphingosine 1-phosphate | - |
? | |
2.7.1.91 | additional information | shows no activity towards DL-threo-dihydrosphingosine, dimethylsphingosine, C2-ceramide, dioleoylacylglycerol, or phosphatidylserine | Homo sapiens | ? | - |
? | |
2.7.1.91 | additional information | shows no activity towards DL-threo-dihydrosphingosine, dimethylsphingosine, C2-ceramide, dioleoylacylglycerol, or phosphatidylserine | Rattus norvegicus | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.1.91 | SK1 | - |
Homo sapiens |
2.7.1.91 | SK1 | - |
Rattus norvegicus |
2.7.1.91 | SK2 | - |
Homo sapiens |
2.7.1.91 | sphinganine kinase | - |
Homo sapiens |
2.7.1.91 | sphinganine kinase | - |
Rattus norvegicus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.7.1.91 | 7.4 | - |
- |
Homo sapiens |
2.7.1.91 | 7.4 | - |
- |
Rattus norvegicus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.91 | ATP | - |
Homo sapiens | |
2.7.1.91 | ATP | - |
Rattus norvegicus |