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Literature summary extracted from

  • Taha, T.A.; Hannun, Y.A.; Obeid, L.M.
    Sphingosine kinase: biochemical and cellular regulation and role in disease (2006), J. Biochem. Mol. Biol., 39, 113-131.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.91 cardiolipin
-
Homo sapiens
2.7.1.91 additional information not affected by bovine serum albumin Homo sapiens
2.7.1.91 additional information not stimulated by phosphatidylcholine or phosphatidylethanolamine Homo sapiens
2.7.1.91 phosphatidic acid
-
Homo sapiens
2.7.1.91 phosphatidylinositol
-
Homo sapiens
2.7.1.91 phosphatidylinositol bisphosphate
-
Homo sapiens
2.7.1.91 phosphatidylserine
-
Homo sapiens
2.7.1.91 Triton X-100
-
Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.91 bovine serum albumin
-
Homo sapiens
2.7.1.91 Cu2+
-
Homo sapiens
2.7.1.91 dimethylsphingosine noncompetitive inhibitor Homo sapiens
2.7.1.91 DL-threo-dihydrosphinganine competitive inhibitor Homo sapiens
2.7.1.91 DL-threo-dihydrosphingosine competitive inhibitor Homo sapiens
2.7.1.91 Fe2+
-
Homo sapiens
2.7.1.91 KCl increasing KCl concentration profoundly inhibits activity Homo sapiens
2.7.1.91 NaCl increasing NaCl concentration profoundly inhibits activity Homo sapiens
2.7.1.91 Triton X-100
-
Homo sapiens
2.7.1.91 Zn2+
-
Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.91 0.005
-
sphingosine
-
Rattus norvegicus
2.7.1.91 0.0138
-
sphingosine
-
Homo sapiens
2.7.1.91 0.0156
-
sphingosine
-
Homo sapiens
2.7.1.91 0.07 0.1 ATP
-
Homo sapiens
2.7.1.91 0.093
-
ATP
-
Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.91 cytosol
-
Homo sapiens 5829
-
2.7.1.91 cytosol
-
Rattus norvegicus 5829
-
2.7.1.91 nucleus
-
Homo sapiens 5634
-
2.7.1.91 nucleus
-
Rattus norvegicus 5634
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.91 K+ increasing KCl concentration stimulates activity Homo sapiens
2.7.1.91 Mg2+ highest activity in the presence of Mg2+ Homo sapiens
2.7.1.91 Mn2+
-
Homo sapiens
2.7.1.91 Na+ increasing NaCl concentration stimulates activity Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.91 Homo sapiens Q9NRA0
-
-
2.7.1.91 Homo sapiens Q9NYA1
-
-
2.7.1.91 Rattus norvegicus Q91V26
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.91 brain
-
Rattus norvegicus
-
2.7.1.91 heart
-
Rattus norvegicus
-
2.7.1.91 kidney
-
Rattus norvegicus
-
2.7.1.91 liver
-
Rattus norvegicus
-
2.7.1.91 lung
-
Rattus norvegicus
-
2.7.1.91 platelet
-
Homo sapiens
-
2.7.1.91 spleen
-
Rattus norvegicus
-
2.7.1.91 thymus
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.91 ATP + DL-threo-dihydrosphingosine
-
Homo sapiens ADP + DL-threo-dihydrosphingosine 1-phosphate
-
?
2.7.1.91 ATP + FTY720
-
Homo sapiens ADP + ?
-
?
2.7.1.91 ATP + phytosphingosine
-
Homo sapiens ADP + phytosphingosine 1-phosphate
-
?
2.7.1.91 ATP + sphinganine
-
Homo sapiens ADP + sphinganine 1-phosphate
-
?
2.7.1.91 ATP + sphinganine SK2 has a higher substrate affinity to sphinganine than to sphingosine Homo sapiens ADP + sphinganine 1-phosphate
-
?
2.7.1.91 ATP + sphingosine
-
Homo sapiens ADP + sphingosine 1-phosphate
-
?
2.7.1.91 ATP + sphingosine
-
Rattus norvegicus ADP + sphingosine 1-phosphate
-
?
2.7.1.91 additional information shows no activity towards DL-threo-dihydrosphingosine, dimethylsphingosine, C2-ceramide, dioleoylacylglycerol, or phosphatidylserine Homo sapiens ?
-
?
2.7.1.91 additional information shows no activity towards DL-threo-dihydrosphingosine, dimethylsphingosine, C2-ceramide, dioleoylacylglycerol, or phosphatidylserine Rattus norvegicus ?
-
?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.91 SK1
-
Homo sapiens
2.7.1.91 SK1
-
Rattus norvegicus
2.7.1.91 SK2
-
Homo sapiens
2.7.1.91 sphinganine kinase
-
Homo sapiens
2.7.1.91 sphinganine kinase
-
Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.1.91 7.4
-
-
Homo sapiens
2.7.1.91 7.4
-
-
Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.91 ATP
-
Homo sapiens
2.7.1.91 ATP
-
Rattus norvegicus