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Literature summary extracted from

  • Takahashi, S.; Hori, K.; Ogasawara, H.; Hiwatashi, K.; Sugiyama, T.
    Effects of nucleotides on the interaction of renin with GlcNAc 2-epimerase (renin binding protein, RnBP) (2006), J. Biochem., 140, 725-730.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
5.1.3.8 ADP stabilizes the dimeric form of the enzyme Sus scrofa
5.1.3.8 ATP stabilizes the dimeric form of the enzyme, inhibits the heterocomplex with renin, prevents inhibition by NEM, inhibits degradation of the enzyme by thermolysin Sus scrofa
5.1.3.8 dATP stabilizes the dimeric form of the enzyme Sus scrofa

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.1.3.8 N-ethylmaleimide NEM, strong inhibitor in absence of ATP at 0.1-0.3 mM, at 5mM inhibition also in presence of ATP Sus scrofa

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
5.1.3.8 40000
-
 monomer, gel filtration Sus scrofa
5.1.3.8 65000
-
 dimer, gel filtration Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
5.1.3.8 Sus scrofa P17560
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.1.3.8 N-acetyl-D-mannosamine
-
 Sus scrofa N-acetyl-D-glucosamine
-
 ?

Subunits

EC Number Subunits Comment Organism
5.1.3.8 dimer resistant to protease digestion Sus scrofa

Synonyms

EC Number Synonyms Comment Organism
5.1.3.8 GlcNAc 2-epimerase
-
 Sus scrofa
5.1.3.8 N-acyl-D-glucosamine 2-epimerase
-
 Sus scrofa
5.1.3.8 N-acylglucosamine 2-epimerase
-
 Sus scrofa
5.1.3.8 renin binding protein
-
 Sus scrofa
5.1.3.8 RNBP inhibits activity of renin, forms heterocomplex with renin, high molecular weight renin, HMW Sus scrofa