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Literature summary extracted from

  • McAllister, K.A.; Peery, R.B.; Zhao, G.
    Acyl carrier protein synthases from Gram-negative, Gram-positive, and atypical bacterial species: Biochemical and structural properties and physiological implications (2006), J. Bacteriol., 188, 4737-4748.
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.8.7 0.0008
-
 apo-[acyl-carrier protein] pH 7.5, 22°C Mycoplasma pneumoniae
2.7.8.7 0.0009
-
 palmitoleoyl-CoA pH 7.5, 22°C Mycoplasma pneumoniae
2.7.8.7 0.001
-
 myristoyl-CoA pH 7.5, 22°C Streptococcus pneumoniae
2.7.8.7 0.0012
-
 palmitoyl-CoA pH 7.5, 22°C Streptococcus pneumoniae
2.7.8.7 0.0013
-
 apo-[acyl-carrier protein] pH 7.5, 22°C Escherichia coli
2.7.8.7 0.0014
-
 decanoyl-CoA pH 7.5, 22°C Mycoplasma pneumoniae
2.7.8.7 0.0015
-
 decanoyl-CoA pH 7.5, 22°C Streptococcus pneumoniae
2.7.8.7 0.0016
-
 palmitoleoyl-CoA pH 7.5, 22°C Streptococcus pneumoniae
2.7.8.7 0.0018
-
 myristoyl-CoA pH 7.5, 22°C Mycoplasma pneumoniae
2.7.8.7 0.0018
-
 apo-[acyl-carrier protein] pH 7.5, 22°C Streptococcus pneumoniae
2.7.8.7 0.0025
-
 myristoleoyl-CoA pH 7.5, 22°C Streptococcus pneumoniae
2.7.8.7 0.004
-
 CoA pH 7.5, 22°C Streptococcus pneumoniae
2.7.8.7 0.0052
-
 crotonyl-CoA pH 7.5, 22°C Mycoplasma pneumoniae
2.7.8.7 0.007
-
 butyryl-CoA pH 7.5, 22°C Streptococcus pneumoniae
2.7.8.7 0.0071
-
 malonyl-CoA pH 7.5, 22°C Escherichia coli
2.7.8.7 0.0077
-
 acetyl-CoA pH 7.5, 22°C Escherichia coli
2.7.8.7 0.0081
-
 butyryl-CoA pH 7.5, 22°C Escherichia coli
2.7.8.7 0.0088
-
 acetoacetyl-CoA pH 7.5, 22°C Escherichia coli
2.7.8.7 0.0093
-
 CoA pH 7.5, 22°C Escherichia coli
2.7.8.7 0.011
-
 acetyl-CoA pH 7.5, 22°C Streptococcus pneumoniae
2.7.8.7 0.015
-
 malonyl-CoA pH 7.5, 22°C Streptococcus pneumoniae
2.7.8.7 0.018
-
 crotonyl-CoA pH 7.5, 22°C Streptococcus pneumoniae
2.7.8.7 0.019
-
 acetoacetyl-CoA pH 7.5, 22°C Streptococcus pneumoniae
2.7.8.7 0.035
-
 butyryl-CoA pH 7.5, 22°C Mycoplasma pneumoniae
2.7.8.7 0.04
-
 CoA pH 7.5, 22°C Mycoplasma pneumoniae
2.7.8.7 0.043
-
 acetyl-CoA pH 7.5, 22°C Mycoplasma pneumoniae
2.7.8.7 0.051
-
 acetoacetyl-CoA pH 7.5, 22°C Mycoplasma pneumoniae
2.7.8.7 0.094
-
 malonyl-CoA pH 7.5, 22°C Mycoplasma pneumoniae

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.8.7 15000
-
 2 * 15000, SDS-PAGE Mycoplasma pneumoniae
2.7.8.7 15000
-
 2 * 15000, SDS-PAGE Escherichia coli
2.7.8.7 29000
-
 gel fitlration Mycoplasma pneumoniae
2.7.8.7 29000
-
 gel fitlration Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
2.7.8.7 Escherichia coli P24224
-
-
2.7.8.7 Mycoplasma pneumoniae
-
-
-
2.7.8.7 Streptococcus pneumoniae
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.8.7 recombinant enzyme Streptococcus pneumoniae
2.7.8.7 recombinant enzyme Mycoplasma pneumoniae
2.7.8.7 recombinant enzyme Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.8.7 acetoacetyl-CoA + apo-[acyl-carrier protein]
-
 Streptococcus pneumoniae ? + holo-[acyl-carrier protein]
-
 ?
2.7.8.7 acetoacetyl-CoA + apo-[acyl-carrier protein]
-
 Mycoplasma pneumoniae ? + holo-[acyl-carrier protein]
-
 ?
2.7.8.7 acetoacetyl-CoA + apo-[acyl-carrier protein]
-
 Escherichia coli ? + holo-[acyl-carrier protein]
-
 ?
2.7.8.7 acetyl-CoA + apo-[acyl-carrier protein]
-
 Streptococcus pneumoniae CoA + acetyl-[acyl-carrier protein]
-
 ?
2.7.8.7 acetyl-CoA + apo-[acyl-carrier protein]
-
 Mycoplasma pneumoniae CoA + acetyl-[acyl-carrier protein]
-
 ?
2.7.8.7 acetyl-CoA + apo-[acyl-carrier protein]
-
 Escherichia coli CoA + acetyl-[acyl-carrier protein]
-
 ?
2.7.8.7 butyryl-CoA + apo-[acyl-carrier protein]
-
 Streptococcus pneumoniae ? + holo-[acyl-carrier protein]
-
 ?
2.7.8.7 butyryl-CoA + apo-[acyl-carrier protein]
-
 Mycoplasma pneumoniae ? + holo-[acyl-carrier protein]
-
 ?
2.7.8.7 butyryl-CoA + apo-[acyl-carrier protein]
-
 Escherichia coli ? + holo-[acyl-carrier protein]
-
 ?
2.7.8.7 CoA + apo-[acyl-carrier protein]
-
 Streptococcus pneumoniae adenosine 3',5'-bisphosphate + holo-[acyl-carrier protein]
-
 ?
2.7.8.7 CoA + apo-[acyl-carrier protein]
-
 Mycoplasma pneumoniae adenosine 3',5'-bisphosphate + holo-[acyl-carrier protein]
-
 ?
2.7.8.7 CoA + apo-[acyl-carrier protein]
-
 Escherichia coli adenosine 3',5'-bisphosphate + holo-[acyl-carrier protein]
-
 ?
2.7.8.7 crotonyl-CoA + apo-[acyl-carrier protein]
-
 Streptococcus pneumoniae ? + holo-[acyl-carrier protein]
-
 ?
2.7.8.7 crotonyl-CoA + apo-[acyl-carrier protein]
-
 Mycoplasma pneumoniae ? + holo-[acyl-carrier protein]
-
 ?
2.7.8.7 decanoyl-CoA + apo-[acyl-carrier protein]
-
 Streptococcus pneumoniae ? + holo-[acyl-carrier protein]
-
 ?
2.7.8.7 decanoyl-CoA + apo-[acyl-carrier protein]
-
 Mycoplasma pneumoniae ? + holo-[acyl-carrier protein]
-
 ?
2.7.8.7 malonyl-CoA + apo-[acyl-carrier protein]
-
 Streptococcus pneumoniae ? + holo-[acyl-carrier protein]
-
 ?
2.7.8.7 malonyl-CoA + apo-[acyl-carrier protein]
-
 Mycoplasma pneumoniae ? + holo-[acyl-carrier protein]
-
 ?
2.7.8.7 malonyl-CoA + apo-[acyl-carrier protein]
-
 Escherichia coli ? + holo-[acyl-carrier protein]
-
 ?
2.7.8.7 myristoleoyl-CoA + apo-[acyl-carrier protein]
-
 Streptococcus pneumoniae ? + holo-[acyl-carrier protein]
-
 ?
2.7.8.7 myristoyl-CoA + apo-[acyl-carrier protein]
-
 Streptococcus pneumoniae ? + holo-[acyl-carrier protein]
-
 ?
2.7.8.7 myristoyl-CoA + apo-[acyl-carrier protein]
-
 Mycoplasma pneumoniae ? + holo-[acyl-carrier protein]
-
 ?
2.7.8.7 palmitoleoyl-CoA + apo-[acyl-carrier protein]
-
 Streptococcus pneumoniae ? + holo-[acyl-carrier protein]
-
 ?
2.7.8.7 palmitoleoyl-CoA + apo-[acyl-carrier protein]
-
 Mycoplasma pneumoniae ? + holo-[acyl-carrier protein]
-
 ?
2.7.8.7 palmitoyl-CoA + apo-[acyl-carrier protein]
-
 Streptococcus pneumoniae ? + holo-[acyl-carrier protein]
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.8.7 dimer 2 * 15000, SDS-PAGE Mycoplasma pneumoniae
2.7.8.7 dimer 2 * 15000, SDS-PAGE Escherichia coli

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.7.8.7 0.0004
-
 malonyl-CoA pH 7.5, 22°C Mycoplasma pneumoniae
2.7.8.7 0.001
-
 acetoacetyl-CoA pH 7.5, 22°C Mycoplasma pneumoniae
2.7.8.7 0.002
-
 CoA pH 7.5, 22°C Mycoplasma pneumoniae
2.7.8.7 0.002
-
 apo-[acyl-carrier protein] pH 7.5, 22°C Mycoplasma pneumoniae
2.7.8.7 0.003
-
 myristoyl-CoA pH 7.5, 22°C Mycoplasma pneumoniae
2.7.8.7 0.003
-
 palmitoleoyl-CoA pH 7.5, 22°C Mycoplasma pneumoniae
2.7.8.7 0.004
-
 butyryl-CoA pH 7.5, 22°C Mycoplasma pneumoniae
2.7.8.7 0.004
-
 decanoyl-CoA pH 7.5, 22°C Mycoplasma pneumoniae
2.7.8.7 0.005
-
 crotonyl-CoA pH 7.5, 22°C Mycoplasma pneumoniae
2.7.8.7 0.009
-
 acetyl-CoA pH 7.5, 22°C Mycoplasma pneumoniae
2.7.8.7 0.1
-
 malonyl-CoA pH 7.5, 22°C Streptococcus pneumoniae
2.7.8.7 0.1
-
 malonyl-CoA pH 7.5, 22°C Escherichia coli
2.7.8.7 0.2
-
 acetyl-CoA pH 7.5, 22°C Streptococcus pneumoniae
2.7.8.7 0.2
-
 acetoacetyl-CoA pH 7.5, 22°C Streptococcus pneumoniae
2.7.8.7 0.2
-
 acetoacetyl-CoA pH 7.5, 22°C Escherichia coli
2.7.8.7 0.2
-
 butyryl-CoA pH 7.5, 22°C Escherichia coli
2.7.8.7 0.2
-
 crotonyl-CoA pH 7.5, 22°C Streptococcus pneumoniae
2.7.8.7 0.3
-
 CoA pH 7.5, 22°C Streptococcus pneumoniae
2.7.8.7 0.3
-
 butyryl-CoA pH 7.5, 22°C Streptococcus pneumoniae
2.7.8.7 0.4
-
 acetyl-CoA pH 7.5, 22°C Escherichia coli
2.7.8.7 0.4
-
 palmitoyl-CoA pH 7.5, 22°C Streptococcus pneumoniae
2.7.8.7 0.4
-
 palmitoleoyl-CoA pH 7.5, 22°C Streptococcus pneumoniae
2.7.8.7 0.5
-
 myristoyl-CoA pH 7.5, 22°C Streptococcus pneumoniae
2.7.8.7 0.5
-
 decanoyl-CoA pH 7.5, 22°C Streptococcus pneumoniae
2.7.8.7 0.5
-
 myristoleoyl-CoA pH 7.5, 22°C Streptococcus pneumoniae
2.7.8.7 0.6
-
 apo-[acyl-carrier protein] pH 7.5, 22°C Streptococcus pneumoniae
2.7.8.7 0.7
-
 apo-[acyl-carrier protein] pH 7.5, 22°C Escherichia coli
2.7.8.7 1
-
 CoA pH 7.5, 22°C Escherichia coli