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Literature summary extracted from

  • Williams, L.; Fresquet, V.; Santander, P.J.; Raushel, F.M.
    The multiple amidation reactions catalyzed by cobyric acid synthetase from Salmonella typhimurium are sequential and dissociative (2007), J. Am. Chem. Soc., 129, 294-295.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.5.10 cobyric acid
-
 Salmonella enterica subsp. enterica serovar Typhimurium

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.3.5.10 0.0007
-
 adenosylcobyrinic acid pentaamide 30°C, pH 7.5 Salmonella enterica subsp. enterica serovar Typhimurium
6.3.5.10 0.0008
-
 adenosylcobyrinic acid tetraamide 30°C, pH 7.5 Salmonella enterica subsp. enterica serovar Typhimurium
6.3.5.10 0.001
-
 adenosylcobyrinic acid triamide 30°C, pH 7.5 Salmonella enterica subsp. enterica serovar Typhimurium
6.3.5.10 0.0027
-
 adenosylcobyrinic acid diamide 30°C, pH 7.5 Salmonella enterica subsp. enterica serovar Typhimurium

Organism

EC Number Organism UniProt Comment Textmining
6.3.5.10 Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.5.10 ATP + adenosylcobyrinic acid diamide + L-glutamine + H2O four carboxylates attached to the corrinoid ring are amidated in a dissociative fashion. The four carboxylates are amidated in a sequence beginning with carboxylate e and followed in turn by carboxylates d, b, and g Salmonella enterica subsp. enterica serovar Typhimurium ADP + phosphate + adenosylcobyric acid + L-glutamate
-
 ?
6.3.5.10 ATP + adenosylcobyrinic acid pentaamide + L-glutamine + H2O four carboxylates attached to the corrinoid ring are amidated in a dissociative fashion. The four carboxylates are amidated in a sequence beginning with carboxylate e and followed in turn by carboxylates d, b, and g Salmonella enterica subsp. enterica serovar Typhimurium ADP + phosphate + adenosylcobyric acid + L-glutamate
-
 ?
6.3.5.10 ATP + adenosylcobyrinic acid tetraamide + L-glutamine + H2O four carboxylates attached to the corrinoid ring are amidated in a dissociative fashion. The four carboxylates are amidated in a sequence beginning with carboxylate e and followed in turn by carboxylates d, b, and g Salmonella enterica subsp. enterica serovar Typhimurium ADP + phosphate + adenosylcobyric acid + L-glutamate
-
 ?
6.3.5.10 ATP + adenosylcobyrinic acid triamide + L-glutamine + H2O four carboxylates attached to the corrinoid ring are amidated in a dissociative fashion. The four carboxylates are amidated in a sequence beginning with carboxylate e and followed in turn by carboxylates d, b, and g Salmonella enterica subsp. enterica serovar Typhimurium ADP + phosphate + adenosylcobyric acid + L-glutamate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.3.5.10 CbiP
-
 Salmonella enterica subsp. enterica serovar Typhimurium
6.3.5.10 cobyric acid synthetase
-
 Salmonella enterica subsp. enterica serovar Typhimurium

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
6.3.5.10 2.4
-
 adenosylcobyrinic acid triamide 30°C, pH 7.5 Salmonella enterica subsp. enterica serovar Typhimurium
6.3.5.10 3.6
-
 adenosylcobyrinic acid tetraamide 30°C, pH 7.5 Salmonella enterica subsp. enterica serovar Typhimurium
6.3.5.10 3.6
-
 adenosylcobyrinic acid diamide 30°C, pH 7.5 Salmonella enterica subsp. enterica serovar Typhimurium
6.3.5.10 8.4
-
 adenosylcobyrinic acid pentaamide 30°C, pH 7.5 Salmonella enterica subsp. enterica serovar Typhimurium

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
6.3.5.10 0.0059
-
 cobyric acid
-
 Salmonella enterica subsp. enterica serovar Typhimurium