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Literature summary extracted from

  • Siderovski, D.P.; Willard, F.S.
    The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits (2005), Int. J. Biol. Sci., 1, 51-66.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.6.5.1 Axin protein member of RA or E subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
3.6.5.1 Axin2 protein member of RA or E subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
3.6.5.1 D-AKAP2 protein
-
 Homo sapiens
3.6.5.1 EGL-10 protein egg-laying defective protein 10 Caenorhabditis elegans
3.6.5.1 FlbA protein
-
 Aspergillus nidulans
3.6.5.1 GRK1 protein member of GRK or G subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
3.6.5.1 GRK2 protein member of GRK or G subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
3.6.5.1 GRK3 protein member of GRK or G subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
3.6.5.1 GRK4 protein member of GRK or G subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
3.6.5.1 GRK5 protein member of GRK or G subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
3.6.5.1 GRK6 protein member of GRK or G subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
3.6.5.1 GRK7 protein member of GRK or G subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
3.6.5.1 LARG protein member of GEF or F subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
3.6.5.1 p115-RhoGEF protein member of GEF or F subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
3.6.5.1 PDZ-RhoGEF protein member of GEF or F subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
3.6.5.1 RGS1 protein human B-lymphocyte, member of R4 or B subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
3.6.5.1 RGS10 protein member of R12 or D subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
3.6.5.1 RGS11 protein member of R7 or C subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
3.6.5.1 RGS12 protein member of R12 or D subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
3.6.5.1 RGS13 protein member of R4 or B subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
3.6.5.1 RGS14 protein member of R12 or D subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
3.6.5.1 RGS16 protein member of R4 or B subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
3.6.5.1 RGS17 protein member of RZ or A subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
3.6.5.1 RGS18 protein member of R4 or B subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
3.6.5.1 RGS19 protein member of RZ or A subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
3.6.5.1 RGS2 protein human T-lymphocyte, member of R4 or B subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
3.6.5.1 RGS20 protein member of RZ or A subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
3.6.5.1 RGS21 protein member of R4 or B subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
3.6.5.1 RGS22 protein
-
 Homo sapiens
3.6.5.1 RGS3 protein member of R4 or B subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
3.6.5.1 RGS4 protein member of R4 or B subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
3.6.5.1 RGS5 protein member of R4 or B subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
3.6.5.1 RGS6 protein member of R7 or C subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
3.6.5.1 RGS7 protein member of R7 or C subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
3.6.5.1 RGS8 protein member of R4 or B subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
3.6.5.1 RGS9 protein member of R7 or C subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
3.6.5.1 SNX13 protein member of SNX or H subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
3.6.5.1 SNX14 protein member of SNX or H subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
3.6.5.1 SNX25 protein member of SNX or H subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling Homo sapiens
3.6.5.1 Sst2 protein Sst2: supersensitivity to pheromone-2 Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.6.5.1 GTP + H2O Homo sapiens
-
 GDP + phosphate
-
 ?
3.6.5.1 GTP + H2O Saccharomyces cerevisiae
-
 GDP + phosphate
-
 ?
3.6.5.1 GTP + H2O Aspergillus nidulans
-
 GDP + phosphate
-
 ?
3.6.5.1 GTP + H2O Caenorhabditis elegans
-
 GDP + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.6.5.1 Aspergillus nidulans
-
 Aspergillus Emericella nidulans
-
3.6.5.1 Caenorhabditis elegans
-
-
-
3.6.5.1 Homo sapiens
-
-
-
3.6.5.1 Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.5.1 GTP + H2O
-
 Homo sapiens GDP + phosphate
-
 ?
3.6.5.1 GTP + H2O
-
 Saccharomyces cerevisiae GDP + phosphate
-
 ?
3.6.5.1 GTP + H2O
-
 Aspergillus nidulans GDP + phosphate
-
 ?
3.6.5.1 GTP + H2O
-
 Caenorhabditis elegans GDP + phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
3.6.5.1 heterotrimer Galpha subunit, GDP-bound inactive, GTP-bound active and betagamma dimer Homo sapiens
3.6.5.1 heterotrimer Galpha subunit, GDP-bound inactive, GTP-bound active and betagamma dimer Saccharomyces cerevisiae
3.6.5.1 heterotrimer Galpha subunit, GDP-bound inactive, GTP-bound active and betagamma dimer Aspergillus nidulans
3.6.5.1 heterotrimer Galpha subunit, GDP-bound inactive, GTP-bound active and betagamma dimer Caenorhabditis elegans

Synonyms

EC Number Synonyms Comment Organism
3.6.5.1 GTP phosphohydrolase
-
 Homo sapiens
3.6.5.1 GTP phosphohydrolase
-
 Saccharomyces cerevisiae
3.6.5.1 GTP phosphohydrolase
-
 Aspergillus nidulans
3.6.5.1 GTP phosphohydrolase
-
 Caenorhabditis elegans
3.6.5.1 heterotrimeric G-protein GTPase
-
 Homo sapiens
3.6.5.1 heterotrimeric G-protein GTPase
-
 Saccharomyces cerevisiae
3.6.5.1 heterotrimeric G-protein GTPase
-
 Aspergillus nidulans
3.6.5.1 heterotrimeric G-protein GTPase
-
 Caenorhabditis elegans