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Literature summary extracted from

  • Chao, J.
    Prostasin (2004), Handbook of Proteolytic Enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , Eds. ) Academic Press, 2, 1708-1709.
No PubMed abstract available

Application

EC Number Application Comment Organism
3.4.21.B6 medicine blood-borne RT-PCR amplification of prostasin transcripts may provide an early diagnosis of disseminated disease in patients with organ-confined carcinoma Homo sapiens
3.4.21.B6 additional information coexpression with the epithelial sodium channel increases the amiloride-sensitive sodium current Xenopus laevis

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.B6
-
 Mus musculus
3.4.21.B6
-
 Rattus norvegicus
3.4.21.B6
-
 Xenopus laevis

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.B6 antipain
-
 Homo sapiens
3.4.21.B6 Aprotinin
-
 Homo sapiens
3.4.21.B6 benzamidine
-
 Homo sapiens
3.4.21.B6 leupeptin
-
 Homo sapiens
3.4.21.B6 prostasin-binding protein
-
 Homo sapiens
3.4.21.B6 prostasin-binding protein
-
 Mus musculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.21.B6 40000
-
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.B6 Homo sapiens
-
-
-
3.4.21.B6 Mus musculus
-
-
-
3.4.21.B6 Rattus norvegicus
-
-
-
3.4.21.B6 Xenopus laevis
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.B6 1960fold Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.B6 bronchus
-
 Homo sapiens
-
3.4.21.B6 colon
-
 Homo sapiens
-
3.4.21.B6 epithelial cell
-
 Homo sapiens
-
3.4.21.B6 kidney in the proximal and distal tubular cells Homo sapiens
-
3.4.21.B6 liver
-
 Homo sapiens
-
3.4.21.B6 lung
-
 Homo sapiens
-
3.4.21.B6 oocyte
-
 Xenopus laevis
-
3.4.21.B6 ovary cancer cell enzyme levels significantly higher than those in control cells Homo sapiens
-
3.4.21.B6 pancreas
-
 Homo sapiens
-
3.4.21.B6 prostate cancer cell downregulation of the enzyme in high-grade prostate cancer as well as in invasive prostate cancer cells Homo sapiens
-
3.4.21.B6 prostate gland enzyme levels 20fold higher than in other tissues Homo sapiens
-
3.4.21.B6 salivary gland in mucous cells Homo sapiens
-
3.4.21.B6 seminal vesicle fluid enzyme levels 20fold higher than in other tissues Homo sapiens
-
3.4.21.B6 urine of males and females Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.B6 D-Phe-Phe-Arg-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens D-Phe-Phe-Arg + 7-amino-4-methylcoumarin
-
 ?
3.4.21.B6 D-Pro-Phe-Arg-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens D-Pro-Phe-Arg + 7-amino-4-methylcoumarin
-
 ?
3.4.21.B6 D-Val-Leu-Arg-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens D-Val-Leu-Arg + 7-amino-4-methylcoumarin
-
 ?
3.4.21.B6 Z-Gly-Pro-Arg-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens Z-Gly-Pro-Arg + 7-amino-4-methylcoumarin
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.B6 channel-activating protease-1
-
 Xenopus laevis

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.21.B6 9
-
-
 Homo sapiens