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Literature summary extracted from

  • Haines, N.; Stewart, B.A.
    Functional roles for beta1,4-N-acetylgalactosaminyltransferase-A in Drosophila larval neurons and muscles (2007), Genetics, 175, 671-679.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
2.4.1.92 additional information beta4GalNAcTA null mutant larvae show frequent backward crawling, reductions in nerve terminal bouton number, decreased spontaneous transmitter release frequency, and short, wide, hypercontracted muscles with low calcium content, indicating a role for this enzyme in the neuromuscular system Drosophila melanogaster

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.244 UDP-N-acetyl-D-galactosamine + N-acetyl-beta-D-glucosaminyl-R group Drosophila sp. (in: flies) beta4Gal-NAcTA has at least three distinct, tissue-specific roles in neurons and muscles. Substrates are present in both neural and muscle cells that require glycosylation by beta4GalNAcTA for normal function UDP + N-acetyl-beta-D-galactosaminyl-(1,4)-N-acetyl-beta-D-glucosaminyl-R group
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.92 Drosophila melanogaster
-
-
-
2.4.1.244 Drosophila sp. (in: flies)
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.92 larva
-
 Drosophila melanogaster
-
2.4.1.92 muscle
-
 Drosophila melanogaster
-
2.4.1.92 neuron
-
 Drosophila melanogaster
-
2.4.1.244 muscle beta4Gal-NAcTA has at least three distinct, tissue-specific roles in neurons and muscles. Substrates are present in both neural and muscle cells that require glycosylation by beta4GalNAcTA for normal function Drosophila sp. (in: flies)
-
2.4.1.244 neuron beta4Gal-NAcTA has at least three distinct, tissue-specific roles in neurons and muscles. Substrates are present in both neural and muscle cells that require glycosylation by beta4GalNAcTA for normal function Drosophila sp. (in: flies)
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.92 UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
-
 Drosophila melanogaster UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
-
 ?
2.4.1.244 UDP-N-acetyl-D-galactosamine + N-acetyl-beta-D-glucosaminyl-R group beta4Gal-NAcTA has at least three distinct, tissue-specific roles in neurons and muscles. Substrates are present in both neural and muscle cells that require glycosylation by beta4GalNAcTA for normal function Drosophila sp. (in: flies) UDP + N-acetyl-beta-D-galactosaminyl-(1,4)-N-acetyl-beta-D-glucosaminyl-R group
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.92 beta 1,4-N-acetylgalactosaminyltransferase-A
-
 Drosophila melanogaster
2.4.1.92 beta4GalNAcTA
-
 Drosophila melanogaster