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Literature summary extracted from

  • Trostchansky, A.; Odonnell, V.B.; Goodwin, D.C.; Landino, L.M.; Marnett, L.J.; Radi, R.; Rubbo, H.
    Interactions between nitric oxide and peroxynitrite during prostaglandin endoperoxide H synthase-1 catalysis: A free radical mechanism of inactivation (2007), Free Radic. Biol. Med., 42, 1029-1038.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.99.1 bicarbonate bicarbonate enhances peroxynitrite-mediated peroxidase inactivation Ovis aries
1.14.99.1 indomethacin
-
Ovis aries
1.14.99.1 peroxynitrite
-
Ovis aries

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.99.1 arachidonate + AH2 + O2 Ovis aries
-
prostaglandin H2 + A + H2O
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.14.99.1 Ovis aries
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.14.99.1
-
Ovis aries

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.99.1 seminal vesicle
-
Ovis aries
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.99.1 arachidonate + AH2 + O2
-
Ovis aries prostaglandin H2 + A + H2O
-
?

Synonyms

EC Number Synonyms Comment Organism
1.14.99.1 PGHS-1
-
Ovis aries
1.14.99.1 prostaglandin endoperoxide H synthase-1
-
Ovis aries

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.14.99.1 25
-
activity assay, determination of cyclooxygenase and peroxidase activity Ovis aries

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.14.99.1 7.4
-
activity assay, determination of cyclooxygenase and peroxidase activity Ovis aries

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.14.99.1 0.0186
-
cyclooxygenase activity, peroxynitrite is incubated with the resting enzyme and 30 s later, activity and protein nitration is analyzed Ovis aries peroxynitrite
1.14.99.1 0.0222
-
peroxidase activity, peroxynitrite is incubated with the resting enzyme and 30 s later, activity and protein nitration is analyzed Ovis aries peroxynitrite
1.14.99.1 0.03
-
cyclooxygenase activity, enzyme is incubated with peroxynitrite in the presence of peroxides and arachidonic acid Ovis aries peroxynitrite
1.14.99.1 0.0388
-
peroxidase activity, enzyme is incubated with peroxynitrite in the presence of peroxides and arachidonic acid Ovis aries peroxynitrite