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Literature summary extracted from

  • Johansson, L.; Arscott, L.D.; Ballou, D.P.; Williams, C.H.; Arner, E.S.
    Studies of an active site mutant of the selenoprotein thioredoxin reductase: the Ser-Cys-Cys-Ser motif of the insect orthologue is not sufficient to replace the Cys-Sec dyad in the mammalian enzyme (2006), Free Radic. Biol. Med., 41, 649-656.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.8.1.9 expressed in Escherichia coli Rattus norvegicus

Protein Variants

EC Number Protein Variants Comment Organism
1.8.1.9 C458S inactive mutant of SCCS Rattus norvegicus
1.8.1.9 C458S/C475T inactive mutant of SCCS Rattus norvegicus
1.8.1.9 C475T inactive mutant of SCCS Rattus norvegicus
1.8.1.9 SCCS mutant with flanking serine residues introduced into the C-terminal tetrapeptide of the wild type enzyme, less than 0.5% activity of the wild type enzyme Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.9 Rattus norvegicus O89049
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.8.1.9
-
Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.9 5,5'-dithiobis(2-nitrobenzoic acid) + NADPH
-
Rattus norvegicus 2-nitro-5-thiobenzoate + NADP+
-
?
1.8.1.9 selenite + NADPH
-
Rattus norvegicus ? + NADP+
-
?
1.8.1.9 thioredoxin + NADP+
-
Rattus norvegicus thioredoxin disulfide + NADPH
-
?

Synonyms

EC Number Synonyms Comment Organism
1.8.1.9 thioredoxin reductase
-
Rattus norvegicus
1.8.1.9 TrxR
-
Rattus norvegicus