Any feedback?
Literature summary extracted from
- Prostaglandin H synthase-catalyzed bioactivation of amphetamines to free radical intermediates that cause CNS regional DNA oxidation and nerve terminal degeneration (2006), FASEB J., 20, 638-650.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 1.14.99.1 | medicine | amphetamines, bioactivated by prostaglandin H synthase, cause reactive oxygen species formation, implicated in amphetamine-initiated neurodegeneration | Mus musculus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.99.1 | Acetylsalicylic acid | - |
Mus musculus |  |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.14.99.1 | 65000 | - |
immunoblot | Mus musculus |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.99.1 | arachidonate + AH2 + O2 | Mus musculus | - |
prostaglandin H2 + A + H2O | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.99.1 | Mus musculus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.99.1 | brain cortex | - |
Mus musculus | - |
| 1.14.99.1 | brain stem | - |
Mus musculus | - |
| 1.14.99.1 | cerebellum | - |
Mus musculus | - |
| 1.14.99.1 | hippocampus | - |
Mus musculus | - |
| 1.14.99.1 | striatum | - |
Mus musculus | - |
| 1.14.99.1 | substantia nigra | - |
Mus musculus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.99.1 | arachidonate + AH2 + O2 | - |
Mus musculus | prostaglandin H2 + A + H2O | - |
? | |
| 1.14.99.1 | arachidonic acid + 3,4-methylenedioxyamphetamine | postulated bioactivation to a neurodegenerative free radical intermediate that can initiate the formation of reactive oxygen species | Mus musculus | ? | - |
? | |
| 1.14.99.1 | arachidonic acid + 3,4-methylenedioxymethamphetamine | postulated bioactivation to a neurodegenerative free radical intermediate that can initiate the formation of reactive oxygen species | Mus musculus | ? | - |
? | |
| 1.14.99.1 | arachidonic acid + methamphetamine | postulated bioactivation to a neurodegenerative free radical intermediate that can initiate the formation of reactive oxygen species | Mus musculus | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.99.1 | PHS | - |
Mus musculus |
| 1.14.99.1 | PHS-1 | - |
Mus musculus |
| 1.14.99.1 | prostaglandin H synthase | - |
Mus musculus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
