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Literature summary extracted from

  • Thomas, D.J.; Li, J.; Waters, S.B.; Xing, W.; Adair, B.M.; Drobna, Z.; Devesa, V.; Styblo, M.
    Arsenic (+3 oxidation state) methyltransferase and the methylation of arsenicals (2007), Exp. Biol. Med., 232, 3-13.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.1.1.137 GSH addition of GSH stimulates the overall rate for As methylation, but inhibits formation of trimethylarsenite Rattus norvegicus
2.1.1.137 GSH addition of GSH stimulates the overall rate for As methylation, but inhibits formation of trimethylarsenite Homo sapiens
2.1.1.137 thioredoxin activates formation of methyl arsenic, dimethyl arsenic, and trimethyl arsenic Rattus norvegicus
2.1.1.137 thioredoxin dependent on, activates formation of methyl arsenic, dimethyl arsenic, and trimethyl arsenic Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.1.137 expression of rat AS3MT in a simian virus 40 (SV40)-transformed human urothelial cell line confers the capacity to methylate inorganic arsenic on cells that otherwise do not express AS3MT and that have a null phenotype for iAs methylation Rattus norvegicus
2.1.1.137 gene arsM, DNA and amino acid sequence determination and analysis, sequence comparisons, phylogenetic analysis, genotype-phenotype correlations for arsenic methylation and AS3MT Gallus gallus
2.1.1.137 gene arsM, DNA and amino acid sequence determination and analysis, sequence comparisons, phylogenetic analysis, genotype-phenotype correlations for arsenic methylation and AS3MT Mus musculus
2.1.1.137 gene arsM, DNA and amino acid sequence determination and analysis, sequence comparisons, phylogenetic analysis, genotype-phenotype correlations for arsenic methylation and AS3MT Rhodopseudomonas palustris
2.1.1.137 gene arsM, DNA and amino acid sequence determination and analysis, sequence comparisons, phylogenetic analysis, genotype-phenotype correlations for arsenic methylation and AS3MT Oncorhynchus mykiss
2.1.1.137 gene arsM, DNA and amino acid sequence determination and analysis, sequence comparisons, phylogenetic analysis, genotype-phenotype correlations for arsenic methylation and AS3MT Strongylocentrotus purpuratus
2.1.1.137 gene arsM, DNA and amino acid sequence determination and analysis, sequence comparisons, phylogenetic analysis, genotype-phenotype correlations for arsenic methylation and AS3MT Ciona intestinalis
2.1.1.137 gene arsM, DNA and amino acid sequence determination and analysis, sequence comparisons, phylogenetic analysis, genotype-phenotype correlations for arsenic methylation and AS3MT Pan troglodytes
2.1.1.137 gene arsM, DNA and amino acid sequence determination and analysis, sequence comparisons, phylogenetic analysis, genotype-phenotype correlations for arsenic methylation and AS3MT Rattus norvegicus
2.1.1.137 gene arsM, DNA and amino acid sequence determination and analysis, sequence comparisons, phylogenetic analysis, genotype-phenotype correlations for arsenic methylation and AS3MT Bos taurus
2.1.1.137 gene arsM, DNA and amino acid sequence determination and analysis, sequence comparisons, phylogenetic analysis, genotype-phenotype correlations for arsenic methylation and AS3MT, recombinant expression Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.137 GSH addition of GSH stimulates the overall rate for As methylation, but inhibits formation of trimethylarsenite Homo sapiens
2.1.1.137 GSH addition of GSH stimulates the overall rate for As methylation, but inhibits formation of trimethylarsenite Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.1.137 cytosol
-
Rattus norvegicus 5829
-
2.1.1.137 cytosol
-
Homo sapiens 5829
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.1.1.137 42000
-
x * 42000, SDS-PAGE Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.137 additional information Gallus gallus enzyme evolutionary analysis ?
-
?
2.1.1.137 additional information Mus musculus enzyme evolutionary analysis ?
-
?
2.1.1.137 additional information Rhodopseudomonas palustris enzyme evolutionary analysis ?
-
?
2.1.1.137 additional information Oncorhynchus mykiss enzyme evolutionary analysis ?
-
?
2.1.1.137 additional information Strongylocentrotus purpuratus enzyme evolutionary analysis ?
-
?
2.1.1.137 additional information Ciona intestinalis enzyme evolutionary analysis ?
-
?
2.1.1.137 additional information Pan troglodytes enzyme evolutionary analysis ?
-
?
2.1.1.137 additional information Rattus norvegicus enzyme evolutionary analysis ?
-
?
2.1.1.137 additional information Homo sapiens enzyme evolutionary analysis ?
-
?
2.1.1.137 additional information Bos taurus enzyme evolutionary analysis ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.137 Bos taurus
-
-
-
2.1.1.137 Bos taurus Q58DQ0 gene arsM
-
2.1.1.137 Ciona intestinalis
-
-
-
2.1.1.137 Ciona intestinalis
-
gene arsM
-
2.1.1.137 Gallus gallus
-
-
-
2.1.1.137 Gallus gallus
-
gene arsM
-
2.1.1.137 Homo sapiens Q9HBK9
-
-
2.1.1.137 Homo sapiens Q9HBK9 gene arsM
-
2.1.1.137 Mus musculus
-
-
-
2.1.1.137 Mus musculus
-
gene arsM
-
2.1.1.137 no activity in Caenorhabditis elegans
-
-
-
2.1.1.137 no activity in Drosophila melanogaster
-
-
-
2.1.1.137 Oncorhynchus mykiss
-
-
-
2.1.1.137 Oncorhynchus mykiss
-
gene arsM
-
2.1.1.137 Pan troglodytes
-
-
-
2.1.1.137 Pan troglodytes
-
gene arsM
-
2.1.1.137 Rattus norvegicus
-
-
-
2.1.1.137 Rattus norvegicus Q8VHT6 adult male Fischer 344 rats, gene arsM
-
2.1.1.137 Rhodopseudomonas palustris
-
gene arsM
-
2.1.1.137 Strongylocentrotus purpuratus
-
gene arsM
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.1.137 native enzyme several thousandfold using pH-dependent fractionation, chromatofocusing, and S-adenosylhomocysteine-affinity chromatography, the purification of AS3MT from liver cytosol is dependent on the presence of 1 mM dithiothreitol and 5 mM GSH Rattus norvegicus

Reaction

EC Number Reaction Comment Organism Reaction ID
2.1.1.137 S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate reaction modelling, overview Gallus gallus
2.1.1.137 S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate reaction modelling, overview Mus musculus
2.1.1.137 S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate reaction modelling, overview Rhodopseudomonas palustris
2.1.1.137 S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate reaction modelling, overview Oncorhynchus mykiss
2.1.1.137 S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate reaction modelling, overview Strongylocentrotus purpuratus
2.1.1.137 S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate reaction modelling, overview Ciona intestinalis
2.1.1.137 S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate reaction modelling, overview Pan troglodytes
2.1.1.137 S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate reaction modelling, overview Rattus norvegicus
2.1.1.137 S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate reaction modelling, overview Homo sapiens
2.1.1.137 S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate reaction modelling, overview Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.137 hepatocyte primary Homo sapiens
-
2.1.1.137 liver
-
Rattus norvegicus
-
2.1.1.137 liver
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.137 additional information enzyme evolutionary analysis Gallus gallus ?
-
?
2.1.1.137 additional information enzyme evolutionary analysis Mus musculus ?
-
?
2.1.1.137 additional information enzyme evolutionary analysis Rhodopseudomonas palustris ?
-
?
2.1.1.137 additional information enzyme evolutionary analysis Oncorhynchus mykiss ?
-
?
2.1.1.137 additional information enzyme evolutionary analysis Strongylocentrotus purpuratus ?
-
?
2.1.1.137 additional information enzyme evolutionary analysis Ciona intestinalis ?
-
?
2.1.1.137 additional information enzyme evolutionary analysis Pan troglodytes ?
-
?
2.1.1.137 additional information enzyme evolutionary analysis Rattus norvegicus ?
-
?
2.1.1.137 additional information enzyme evolutionary analysis Homo sapiens ?
-
?
2.1.1.137 additional information enzyme evolutionary analysis Bos taurus ?
-
?
2.1.1.137 S-adenosyl-L-methionine + arsenite
-
Gallus gallus S-adenosyl-L-homocysteine + methylarsonate
-
?
2.1.1.137 S-adenosyl-L-methionine + arsenite
-
Mus musculus S-adenosyl-L-homocysteine + methylarsonate
-
?
2.1.1.137 S-adenosyl-L-methionine + arsenite
-
Rattus norvegicus S-adenosyl-L-homocysteine + methylarsonate
-
?
2.1.1.137 S-adenosyl-L-methionine + arsenite
-
Bos taurus S-adenosyl-L-homocysteine + methylarsonate
-
?
2.1.1.137 S-adenosyl-L-methionine + arsenite
-
Oncorhynchus mykiss S-adenosyl-L-homocysteine + methylarsonate
-
?
2.1.1.137 S-adenosyl-L-methionine + arsenite
-
Ciona intestinalis S-adenosyl-L-homocysteine + methylarsonate
-
?
2.1.1.137 S-adenosyl-L-methionine + arsenite
-
Pan troglodytes S-adenosyl-L-homocysteine + methylarsonate
-
?
2.1.1.137 S-adenosyl-L-methionine + arsenite
-
Homo sapiens S-adenosyl-L-homocysteine + methylarsonate
-
?

Subunits

EC Number Subunits Comment Organism
2.1.1.137 ? x * 42000, SDS-PAGE Rattus norvegicus

Synonyms

EC Number Synonyms Comment Organism
2.1.1.137 arsenic (+3 oxidation state) methyltransferase
-
Gallus gallus
2.1.1.137 arsenic (+3 oxidation state) methyltransferase
-
Mus musculus
2.1.1.137 arsenic (+3 oxidation state) methyltransferase
-
Rattus norvegicus
2.1.1.137 arsenic (+3 oxidation state) methyltransferase
-
Bos taurus
2.1.1.137 arsenic (+3 oxidation state) methyltransferase
-
Rhodopseudomonas palustris
2.1.1.137 arsenic (+3 oxidation state) methyltransferase
-
Oncorhynchus mykiss
2.1.1.137 arsenic (+3 oxidation state) methyltransferase
-
Strongylocentrotus purpuratus
2.1.1.137 arsenic (+3 oxidation state) methyltransferase
-
Ciona intestinalis
2.1.1.137 arsenic (+3 oxidation state) methyltransferase
-
Pan troglodytes
2.1.1.137 arsenic (+3 oxidation state) methyltransferase
-
Homo sapiens
2.1.1.137 ArsM protein
-
Gallus gallus
2.1.1.137 ArsM protein
-
Mus musculus
2.1.1.137 ArsM protein
-
Rhodopseudomonas palustris
2.1.1.137 ArsM protein
-
Oncorhynchus mykiss
2.1.1.137 ArsM protein
-
Strongylocentrotus purpuratus
2.1.1.137 ArsM protein
-
Ciona intestinalis
2.1.1.137 ArsM protein
-
Pan troglodytes
2.1.1.137 ArsM protein
-
Rattus norvegicus
2.1.1.137 ArsM protein
-
Homo sapiens
2.1.1.137 ArsM protein
-
Bos taurus
2.1.1.137 AS3MT
-
Gallus gallus
2.1.1.137 AS3MT
-
Mus musculus
2.1.1.137 AS3MT
-
Rattus norvegicus
2.1.1.137 AS3MT
-
Bos taurus
2.1.1.137 AS3MT
-
Rhodopseudomonas palustris
2.1.1.137 AS3MT
-
Oncorhynchus mykiss
2.1.1.137 AS3MT
-
Strongylocentrotus purpuratus
2.1.1.137 AS3MT
-
Ciona intestinalis
2.1.1.137 AS3MT
-
Pan troglodytes
2.1.1.137 AS3MT
-
Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.1.1.137 37
-
assay at Rattus norvegicus
2.1.1.137 37
-
assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.1.1.137 7
-
assay at Rattus norvegicus
2.1.1.137 7 7.4 assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.1.137 S-adenosyl-L-methionine
-
Gallus gallus
2.1.1.137 S-adenosyl-L-methionine
-
Mus musculus
2.1.1.137 S-adenosyl-L-methionine
-
Rhodopseudomonas palustris
2.1.1.137 S-adenosyl-L-methionine
-
Oncorhynchus mykiss
2.1.1.137 S-adenosyl-L-methionine
-
Strongylocentrotus purpuratus
2.1.1.137 S-adenosyl-L-methionine
-
Ciona intestinalis
2.1.1.137 S-adenosyl-L-methionine
-
Pan troglodytes
2.1.1.137 S-adenosyl-L-methionine
-
Rattus norvegicus
2.1.1.137 S-adenosyl-L-methionine
-
Homo sapiens
2.1.1.137 S-adenosyl-L-methionine
-
Bos taurus