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Literature summary extracted from
- Human cyclooxygenase-1b is not the elusive target of acetaminophen (2006), Eur. J. Pharmacol., 551, 50-53.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 1.14.99.1 | medicine | inhibition of cyclooxygenases is a mode of antiinflammatory drugs | Homo sapiens |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.14.99.1 | for transfection of COS-7 cells | Homo sapiens |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 1.14.99.1 | cyclooxygenase-1bdeltaG | mutant, in which the frame shift in the splice variant human cyclooxygenase-1b is corrected | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.99.1 | aspirin | - |
Homo sapiens |  |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.14.99.1 | 68000 | - |
human cyclooxygenase-1, estimated by SDS-PAGE and Western blotting, detected with a cyclooxygenase-1 antibody | Homo sapiens |
| 1.14.99.1 | 72000 | - |
human cyclooxygenase-1bdeltaG, estimated by SDS-PAGE and Western blotting, detected with a cyclooxygenase-1 and a FLAG-tag antibody | Homo sapiens |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.99.1 | arachidonate + AH2 + O2 | Homo sapiens | - |
prostaglandin H2 + A + H2O | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.99.1 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.99.1 | platelet | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.99.1 | arachidonate + AH2 + O2 | - |
Homo sapiens | prostaglandin H2 + A + H2O | - |
? | |
| 1.14.99.1 | arachidonic acid + AH2 + 2 O2 | activity assay | Homo sapiens | 6-keto-prostaglandin F1alpha + A + H2O | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.99.1 | cyclooxygenase-1b | cyclooxygenase-1 splice variant | Homo sapiens |
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Release 2023.1 (January 2023)
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