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Literature summary extracted from

  • Ye, P.; Kenyon, C.J.; MacKenzie, S.M.; Jong, A.S.; Miller, C.; Gray, G.A.; Wallace, A.; Ryding, A.S.; Mullins, J.J.; McBride, M.W.; Graham, D.; Fraser, R.; Connell, J.M.; Davies, E.
    The aldosterone synthase (CYP11B2) and 11beta-hydroxylase (CYP11B1) genes are not expressed in the rat heart (2005), Endocrinology, 146, 5287-5293.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.15.4 additional information treatment of adult rate ventricular myocytes ACTH and angiotensin II has no stimulatory effect on CYP11B1 and CYP11B2 expression Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.15.4 11-deoxy-cortisol + reduced ferredoxin + O2 Rattus norvegicus
-
 cortisol + ferredoxin + H2O
-
 ?
1.14.15.4 18-hydroxycorticosterone + reduced ferredoxin + O2 Rattus norvegicus
-
 aldosterone + ferredoxin + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.15.4 Rattus norvegicus
-
 male Wistar rats with heart failure induced by coronary artery ligation and sham-operated controls, stroke-prone spontaneously hypertensive rats and Wistar Kyoto rats as controls, cyp1a1Ren-2 transgenic rats and Fischer controls, and adult Sprague-Dawley rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.15.4 adrenal cortex
-
 Rattus norvegicus
-
1.14.15.4 heart cardiac tissue from several rat models of cardiovascular pathology, low constitutive expression, which seems to be of no physiologic relevance Rattus norvegicus
-
1.14.15.4 additional information no activity in adult ventricular myocyte Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.14.15.4 additional information
-
 CYP11B2 and CYP11B1 expression analysis in male Wistar rats with heart failure induced by coronary artery ligation and sham-operated controls, in stroke-prone spontaneously hypertensive rats and Wistar Kyoto rats as controls, in cyp1a1Ren-2 transgenic rats and Fischer controls, and in isolated adult Sprague-Dawley ventricular myocytes incubated with 11-deoxycorticosterone, overview Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.15.4 11-deoxy-cortisol + reduced ferredoxin + O2
-
 Rattus norvegicus cortisol + ferredoxin + H2O
-
 ?
1.14.15.4 18-hydroxycorticosterone + reduced ferredoxin + O2
-
 Rattus norvegicus aldosterone + ferredoxin + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.15.4 11beta-hydroxylase
-
 Rattus norvegicus
1.14.15.4 Aldosterone synthase
-
 Rattus norvegicus
1.14.15.4 CYP11B1
-
 Rattus norvegicus
1.14.15.4 CYP11B2
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.15.4 Ferredoxin
-
 Rattus norvegicus