Literature summary extracted from

Koch, U.; Narjes, F.
Recent progress in the development of inhibitors of the hepatitis C virus RNA-dependent RNA polymerase (2007), Curr. Top. Med. Chem., 7, 1302-1329.

Application

EC Number	Application	Comment	Organism
2.7.7.48	medicine	NS5B RdRp is a prime target for therapeutic intervention of hepatitis C virus infection	Hepacivirus C
2.7.7.48	medicine	NS5B RNA-dependent RNA polymerase is essential for replication of hepatitis C virus and is a prime target for therapeutic intervention	Hepacivirus C

Inhibitors

EC Number	Inhibitors	Comment	Organism
2.7.7.48	(1R)-6-bromo-N-[(1S)-1-phenylethyl]-2,3,4,9-tetrahydro-1H-carbazol-1-amine	-	Hepacivirus C
2.7.7.48	(1S)-1-(4-aminofuro[3,2-d]pyrimidin-7-yl)-1,4-anhydro-2-C-methyl-D-ribitol	-	Hepacivirus C
2.7.7.48	(1S)-1-(4-aminothieno[3,2-d]pyrimidin-7-yl)-1,4-anhydro-2-C-methyl-D-ribitol	-	Hepacivirus C
2.7.7.48	(2E)-3-(4-[[(1-[[(1-cyclohexyl-2-furan-3-yl-1H-benzimidazol-5-yl)carbonyl]amino]cyclobutyl)carbonyl]amino]phenyl)prop-2-enoic acid	-	Hepacivirus C
2.7.7.48	(2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-2-azido-2-[[(2-methylpropanoyl)oxy]methyl]tetrahydrofuran-3,4-diyl bis(2-methylpropanoate)	-	Hepacivirus C
2.7.7.48	(2S)-(((5Z)-5-[(5-ethyl-2-furyl)methylene]-4-oxo-4,5-dihydro-1,3-thiazol-2-yl)amino)(4-fluorophenyl)acetic acid	-	Hepacivirus C
2.7.7.48	(2S)-1-[(2-amino-4-chloro-5-methylphenyl)sulfonyl]pyrrolidine-2-carboxylic acid	-	Hepacivirus C
2.7.7.48	(2S)-1-[(3,4,5-trichloro-2-hydroxyphenyl)sulfonyl]pyrrolidine-2-carboxylic acid	-	Hepacivirus C
2.7.7.48	(2S)-1-[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]pyrrolidine-2-carboxylic acid	-	Hepacivirus C
2.7.7.48	(2S)-2-[(2,4-dichlorobenzoyl)(3-nitrobenzyl)amino]-3-phenylpropanoic acid	-	Hepacivirus C
2.7.7.48	(2S,4S,5R)-2-(2-methylpropyl)-5-thiophen-2-yl-1-[[4-(trifluoromethyl)phenyl]carbonyl]pyrrolidine-2,4-dicarboxylic acid	-	Hepacivirus C
2.7.7.48	(2S,5R)-1-[(4-tert-butylphenyl)carbonyl]-2-(2-methylpropyl)-5-(1,3-thiazol-2-yl)-2,5-dihydro-1H-pyrrole-2,4-dicarboxylic acid	-	Hepacivirus C
2.7.7.48	(2Z)-2-(benzoylamino)-3-(5-phenyl-2-furyl)acrylic acid	-	Hepacivirus C
2.7.7.48	(2Z)-2-(benzoylamino)-3-[4-(2-bromophenoxy)phenyl]acrylic acid	-	Hepacivirus C
2.7.7.48	(4S,5R)-1-[(4-tert-butyl-3-methoxyphenyl)carbonyl]-4-methoxy-2-(2-methylpropyl)-5-(1,3-thiazol-2-yl)-L-proline	-	Hepacivirus C
2.7.7.48	(5-cyano-6-fluoro-8-methyl-1-propyl-3,4-dihydro-1H-[1]benzothieno[2,3-c]pyran-1-yl)acetic acid	-	Hepacivirus C
2.7.7.48	(5-cyano-8-methyl-1-propyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl)acetic acid	-	Hepacivirus C
2.7.7.48	(5S)-5-tert-butyl-3-(1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)-4-hydroxy-1-(3-methylbutyl)-1,5-dihydro-2H-pyrrol-2-one	-	Hepacivirus C
2.7.7.48	(6R,7R,8S,9R)-4-bromo-7,8-dihydroxy-7,8,9,10-tetrahydro-5H,6H-6,9-epoxy-1,2,5a,10a-tetraazacycloocta[1,2,3-cd]inden-5-one	-	Hepacivirus C
2.7.7.48	([[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]oxy]methyl)phosphonic acid	-	Hepacivirus C
2.7.7.48	1-(2-cyclopropylethyl)-3-(1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)-6-fluoro-4-hydroxyquinolin-2(1H)-one	-	Hepacivirus C
2.7.7.48	1-(cyclobutylamino)-3-(1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)-4-hydroxyquinolin-2(1H)-one	-	Hepacivirus C
2.7.7.48	1-cyclohexyl-2-(3-furyl)-1H-benzimidazole-5-carboxylic acid	-	Hepacivirus C
2.7.7.48	1-cyclohexyl-2-(4-[[4-(dimethylcarbamoyl)phenyl](phenyl)methoxy]-2-fluorophenyl)-1H-benzimidazole-5-carboxylic acid	-	Hepacivirus C
2.7.7.48	1-cyclohexyl-2-furan-3-yl-N-[(1S)-2-(5-hydroxy-1H-indol-3-yl)-1-(1,3-thiazol-4-yl)ethyl]-1H-benzimidazole-5-carboxamide	-	Hepacivirus C
2.7.7.48	1-cyclohexyl-2-phenyl-1H-benzimidazole-5-carboxylic acid	-	Hepacivirus C
2.7.7.48	1-cyclohexyl-2-phenyl-1H-indole-5-carboxylic acid	-	Hepacivirus C
2.7.7.48	1-cyclohexyl-N-[2-(3,4-dimethoxyphenyl)ethyl]-2-pyridin-2-yl-1H-benzimidazole-5-carboxamide	-	Hepacivirus C
2.7.7.48	1-methyl-N-[4-(pyrrolidin-1-ylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide	first-in-class nonnucleoside inhibitor of RNA-dependent RNA polymerase complex activity, highly active against multiple primary isolates of diverse measles virus genotypes circulating worldwide, high developmental potential as a potent therapeutic against measles virus, active concentrations of 35-145 nM	Measles morbillivirus
2.7.7.48	1-[(4-tert-butyl-3-methoxyphenyl)carbonyl]-4-[(2-chlorophenyl)carbamoyl]-2-(1,3-thiazol-4-ylmethyl)piperazine-2-carboxylic acid	-	Hepacivirus C
2.7.7.48	12-cyclohexylindolo[1,2-c][1,3]benzoxazine-9-carboxylic acid	dihedral angle between the C2-aryl group and the indole ring is 24°	Hepacivirus C
2.7.7.48	13-cyclohexyl-5-(2-piperidin-1-ylethyl)-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepine-10-carboxylic acid	-	Hepacivirus C
2.7.7.48	13-cyclohexyl-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepine-10-carboxylic acid	dihedral angle between the C2-aryl group and the indole ring is 46°	Hepacivirus C
2.7.7.48	13-cyclohexyl-6,7-dihydro-5H-indolo[2,1-a][2]benzazepine-10-carboxylic acid	dihedral angle between the C2-aryl group and the indole ring is 53°	Hepacivirus C
2.7.7.48	13-cyclohexyl-6,7-dihydroindolo[1,2-d][1,4]benzothiazepine-10-carboxylate	dihedral angle between the C2-aryl group and the indole ring is 56°	Hepacivirus C
2.7.7.48	13-cyclohexyl-6,7-dihydroindolo[1,2-d][1,4]benzoxazepine-10-carboxylic acid	dihedral angle between the C2-aryl group and the indole ring is 43°	Hepacivirus C
2.7.7.48	14-cyclohexyl-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate	dihedral angle between the C2-aryl group and the indole ring is 61°	Hepacivirus C
2.7.7.48	2'-C-methyl-3'-O-L-valylcytidine	-	Hepacivirus C
2.7.7.48	2'-C-methyladenosine	-	Hepacivirus C
2.7.7.48	2'-C-methylcytidine	-	Hepacivirus C
2.7.7.48	2'-C-methylguanosine	-	Hepacivirus C
2.7.7.48	2'-deoxy-2'-fluoro-2'-methylcytidine	-	Hepacivirus C
2.7.7.48	2'-deoxy-2'-fluorocytidine	-	Hepacivirus C
2.7.7.48	2'-O-methylcytidine	-	Hepacivirus C
2.7.7.48	2-(2-C-methyl-b-D-ribofuranosyl)-2,6-dihydro-7H-2,3,5,6-tetraazabenzo[cd]azulen-7-one	-	Hepacivirus C
2.7.7.48	2-(3-[[(2-chlorobenzyl)carbamoyl]amino]thiophen-2-yl)-5,6-dihydroxypyrimidine-4-carboxylic acid	-	Hepacivirus C
2.7.7.48	2-(4-benzylphenyl)-3-cyclohexyl-1-methyl-1H-indole-6-carboxylic acid	-	Hepacivirus C
2.7.7.48	2-(4-chlorophenyl)-3-cyclohexyl-1-[2-[4-(diethylamino)piperidin-1-yl]-2-oxoethyl]-1H-indole-6-carboxylic acid	-	Hepacivirus C
2.7.7.48	2-(4-[[4'-chloro-4-(2-oxopyrrolidin-1-yl)biphenyl-2-yl]methoxy]-2-fluorophenyl)-1-cyclohexyl-1H-benzimidazole-5-carboxylic acid	-	Hepacivirus C
2.7.7.48	2-([3-[1-(2-cyclopropylethyl)-6-fluoro-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl]oxy)acetamide	-	Hepacivirus C
2.7.7.48	2-([3-[4-hydroxy-1-(3-methylbutyl)-2-oxo-1,2-dihydro-1,8-naphthyridin-3-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl]oxy)acetamide	-	Hepacivirus C
2.7.7.48	2-amino-7-(2-C-methyl-beta-D-ribofuranosyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one	-	Hepacivirus C
2.7.7.48	2-[4-(2-[(2R)-2-cyclopentyl-4-hydroxy-5-[(6-methyl[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl]-6-oxo-3,6-dihydro-2H-pyran-2-yl]ethyl)-2-fluorophenyl]-2-methylpropanenitrile	-	Hepacivirus C
2.7.7.48	2-[4-(benzyloxy)phenyl]-1-cyclopentyl-1H-benzimidazole-5-carboxamide	-	Hepacivirus C
2.7.7.48	2-[4-(benzyloxy)phenyl]-1-cyclopentyl-1H-benzimidazole-5-carboxylic acid	-	Hepacivirus C
2.7.7.48	2-[4-(benzyloxy)phenyl]-3-cyclohexyl-1-[2-(dimethylamino)-2-oxoethyl]-1H-indole-6-carboxylic acid	-	Hepacivirus C
2.7.7.48	2-[4-([4'-chloro-4-[(4-hydroxypiperidin-1-yl)carbonyl]biphenyl-2-yl]methoxy)-2-fluorophenyl]-1-cyclohexyl-1H-benzimidazole-5-carboxylic acid	-	Hepacivirus C
2.7.7.48	3'-deoxy-5'-O-([2-[(2,2-dimethyl-1-methylidenepropyl)sulfanyl]ethoxy][2-[(2,2-dimethylpropanoyl)sulfanyl]ethoxy]phosphoryl)cytidine	-	Hepacivirus C
2.7.7.48	3'-deoxycytidine	-	Hepacivirus C
2.7.7.48	3-(1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)-4-hydroxy-1-(3-methylbutyl)quinolin-2(1H)-one	-	Hepacivirus C
2.7.7.48	3-(2-C-methyl-b-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-2,7(3H,8H)-dione	-	Hepacivirus C
2.7.7.48	3-(benzyloxy)-13-cyclohexyl-6,7-dihydroindolo[1,2-d][1,4]benzoxazepine-10-carboxylic acid	-	Hepacivirus C
2.7.7.48	3-(isopropyl[(4-methylphenyl)sulfonyl]amino)-5-phenylthiophene-2-carboxylic acid	-	Hepacivirus C
2.7.7.48	3-([(2,4-dimethylphenyl)sulfonyl]amino)-5-phenylthiophene-2-carboxylic acid	-	Hepacivirus C
2.7.7.48	3-([(4-chloro-2,5-dimethylphenyl)sulfonyl]amino)-5-phenylthiophene-2-carboxamide	-	Hepacivirus C
2.7.7.48	3-cyclohexyl-1-(2-oxo-2-piperidin-1-ylethyl)-2-phenyl-1H-indole-6-carboxylic acid	-	Hepacivirus C
2.7.7.48	3-cyclohexyl-1-(2-[methyl[(1-methylpiperidin-3-yl)methyl]amino]-2-oxoethyl)-2-phenyl-1H-indole-6-carboxylic acid	-	Hepacivirus C
2.7.7.48	3-cyclohexyl-1-[2-(dimethylamino)-2-oxoethyl]-2-(4-methoxyphenyl)-1H-indole-6-carboxylic acid	-	Hepacivirus C
2.7.7.48	3-cyclohexyl-1-[2-(dimethylamino)-2-oxoethyl]-2-phenyl-1H-indole-6-carboxylic acid	-	Hepacivirus C
2.7.7.48	3-cyclohexyl-1-[2-(dimethylamino)-2-oxoethyl]-2-phenyl-1H-pyrrolo[2,3-b]pyridine-6-carboxylic acid	-	Hepacivirus C
2.7.7.48	3-cyclohexyl-2-(3-furyl)-1-methyl-1H-indole-6-carboxylic acid	-	Hepacivirus C
2.7.7.48	3-cyclohexyl-2-(3-furyl)-1H-indole-6-carboxylic acid	-	Hepacivirus C
2.7.7.48	3-cyclohexyl-2-furan-3-yl-1-[2-oxo-2-(4-pyrrolidin-1-ylpiperidin-1-yl)ethyl]-1H-indole-6-carboxylic acid	-	Hepacivirus C
2.7.7.48	3-cyclohexyl-2-furan-3-yl-N-[(1S)-2-(5-hydroxy-1H-indol-3-yl)-1-(1,3-thiazol-4-yl)ethyl]-1-methyl-1H-indole-6-carboxamide	-	Hepacivirus C
2.7.7.48	3-cyclohexyl-2-phenyl-1H-indole-6-carboxylic acid	-	Hepacivirus C
2.7.7.48	3-cyclohexyl-2-phenyl-1H-pyrrolo[2,3-b]pyridine-6-carboxylic acid	-	Hepacivirus C
2.7.7.48	3-cyclohexyl-2-phenyl-1H-pyrrolo[3,2-b]pyridine-6-carboxylic acid	-	Hepacivirus C
2.7.7.48	3-cyclohexyl-2-phenyl-3H-thieno[2,3-d]imidazole-5-carboxylic acid	-	Hepacivirus C
2.7.7.48	3-cyclohexyl-2-phenylquinoline-6-carboxylic acid	-	Hepacivirus C
2.7.7.48	3-[(4-amino-2-tert-butyl-5-methylphenyl)sulfanyl]-6-cyclopentyl-4-hydroxy-6-[2-(4-hydroxyphenyl)ethyl]-5,6-dihydro-2H-pyran-2-one	-	Hepacivirus C
2.7.7.48	3-[[(trans-4-methylcyclohexyl)carbonyl](1-methylethyl)amino]-5-phenylthiophene-2-carboxylic acid	-	Hepacivirus C
2.7.7.48	3-[[(trans-4-methylcyclohexyl)carbonyl](1-methylpiperidin-4-yl)amino]-5-phenylthiophene-2-carboxylic acid	-	Hepacivirus C
2.7.7.48	4'-azido-D-arabinofuranosylcytosine	-	Hepacivirus C
2.7.7.48	4'-azidocytidine	-	Hepacivirus C
2.7.7.48	4-(2-C-methyl-b-D-ribofuranosyl)-3-oxo-3,4-dihydropyrazine-2-carboxamide	-	Hepacivirus C
2.7.7.48	4-methyl-N-((5Z)-5-[(5-methyl-2-furyl)methylene]-4-oxo-4,5-dihydro-1,3-thiazol-2-yl)benzenesulfonamide	-	Hepacivirus C
2.7.7.48	5'-O-([2-[(2,2-dimethyl-1-methylidenepropyl)sulfanyl]ethoxy][2-[(2,2-dimethylpropanoyl)sulfanyl]ethoxy]phosphoryl)-2'-O-methylcytidine	-	Hepacivirus C
2.7.7.48	5,6-dihydroxy-2-(1,3-thiazol-5-yl)pyrimidine-4-carboxylic acid	-	Hepacivirus C
2.7.7.48	5,6-dihydroxy-2-(2-thienyl)pyrimidine-4-carboxylic acid	-	Hepacivirus C
2.7.7.48	5,6-dihydroxy-2-phenylpyrimidine-4-carboxylic acid	-	Hepacivirus C
2.7.7.48	5,6-dihydroxy-2-[4-(([(1-naphthylsulfonyl)amino]carbonyl)amino)-3-thienyl]pyrimidine-4-carboxylic acid	-	Hepacivirus C
2.7.7.48	5,8-dichloro-3-propyl-1,2,3,4-tetrahydrocyclopenta[b]indole-3-carboxylic acid	-	Hepacivirus C
2.7.7.48	5-(4-cyanophenyl)-3-([(2-methylphenyl)sulfonyl]amino)thiophene-2-carboxylic acid	-	Hepacivirus C
2.7.7.48	5-(carboxymethoxy)-N-[(1-cyclohexyl-2-furan-3-yl-1H-benzimidazol-5-yl)carbonyl]-L-tryptophan	-	Hepacivirus C
2.7.7.48	5-([3,5-bis(trifluoromethyl)phenyl]amino)-3-hydroxyisothiazole-4-carbonitrile	-	Hepacivirus C
2.7.7.48	5-cyclopropyl-2-(4-fluorophenyl)-6-[(2-hydroxyethyl)(methylsulfonyl)amino]-N-methyl-1-benzofuran-3-carboxamide	-	Hepacivirus C
2.7.7.48	5-ethyl-1-(2-C-methyl-b-D-ribofuranosyl)-1,5-dihydro-1,4,5,6,8-pentaazaacenaphthylen-3-amine	-	Hepacivirus C
2.7.7.48	5-fluoro-7-(2-C-methyl-beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine	-	Hepacivirus C
2.7.7.48	5-[(3,5-dichlorophenyl)amino]-3-hydroxyisothiazole-4-carbonitrile	-	Hepacivirus C
2.7.7.48	6-cyclohexyl-4-[2-(dimethylamino)-2-oxoethyl]-5-phenyl-4H-thieno[3,2-b]pyrrole-2-carboxylic acid	-	Hepacivirus C
2.7.7.48	6-cyclohexyl-5-phenyl-4H-thieno[3,2-b]pyrrole-2-carboxylic acid	-	Hepacivirus C
2.7.7.48	6-ethoxy-9-(2-C-methyl-b-D-ribofuranosyl)-9H-purine	-	Hepacivirus C
2.7.7.48	6-furan-3-yl-9-b-D-ribofuranosyl-9H-purine	-	Hepacivirus C
2.7.7.48	6-methoxy-9-(2-C-methyl-b-D-ribofuranosyl)-9H-purine	-	Hepacivirus C
2.7.7.48	6-[2-(3-chloro-4-methoxyphenyl)ethyl]-6-cyclopentyl-4-hydroxy-3-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]-5,6-dihydro-2H-pyran-2-one	-	Hepacivirus C
2.7.7.48	6-[2-(methoxysulfinyl)hydrazino]-9-(2-C-methyl-b-D-ribofuranosyl)-9H-purine	-	Hepacivirus C
2.7.7.48	7-(2-C-methyl-b-D-ribofuranosyl)-5-nitro-7H-pyrrolo[2,3-d]pyrimidin-4-amine	-	Hepacivirus C
2.7.7.48	7-(2-C-methyl-beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine	-	Hepacivirus C
2.7.7.48	9-(5,6-dideoxy-2-C-methyl-6-phosphono-b-D-ribo-hexofuranosyl)-9H-purin-6-amine	-	Hepacivirus C
2.7.7.48	9-(5,6-dideoxy-6-phosphono-b-D-ribo-hexofuranosyl)-9H-purin-6-amine	-	Hepacivirus C
2.7.7.48	9-(5-O-[bis[2-(acetylsulfanyl)ethoxy]phosphoryl]-2-C-methyl-b-D-ribofuranosyl)-6-ethoxy-9H-purine	-	Hepacivirus C
2.7.7.48	A-782759	-	Hepacivirus C
2.7.7.48	A-837093	-	Hepacivirus C
2.7.7.48	N-[(13-cyclohexyl-6,7-dihydroindolo[1,2-d][1,4]benzoxazepin-10-yl)carbonyl]-2-methylalanine	-	Hepacivirus C
2.7.7.48	N-[(1R)-6-chloro-2,3,4,9-tetrahydro-1H-carbazol-1-yl]pyridine-2-carboxamide	-	Hepacivirus C
2.7.7.48	N-[(2,4-dichlorophenyl)carbonyl]-N-[3-(trifluoromethyl)benzyl]-L-phenylalanine	-	Hepacivirus C
2.7.7.48	N-[(5Z)-5-((5-[2-chloro-5-(trifluoromethyl)phenyl]-2-furyl)methylene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]benzenesulfonamide	-	Hepacivirus C
2.7.7.48	N-[(5Z)-5-(3,4-dichlorobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]benzenesulfonamide	-	Hepacivirus C
2.7.7.48	N-[(5Z)-5-(4-bromobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]benzenesulfonamide	-	Hepacivirus C
2.7.7.48	N-[(Z)-2-[4-(2-bromophenoxy)phenyl]-1-[(2-hydroxyethyl)carbamoyl]ethenyl]benzamide	-	Hepacivirus C
2.7.7.48	N-[3-[(5S)-5-tert-butyl-1-(3-chloro-4-fluorobenzyl)-4-hydroxy-2-oxo-2,5-dihydro-1H-pyrrol-3-yl]-1,1-dioxido-4H-1,2-benzothiazin-7-yl]methanesulfonamide	-	Hepacivirus C
2.7.7.48	N-[3-[(5S)-5-tert-butyl-1-(4-fluorobenzyl)-4-hydroxy-2-oxo-2,5-dihydro-1H-pyrrol-3-yl]-1,1-dioxido-1,2-benzisothiazol-6-yl]methanesulfonamide	-	Hepacivirus C
2.7.7.48	N-[3-[1-(cyclobutylamino)-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl]sulfamide	-	Hepacivirus C
2.7.7.48	N-[3-[4-hydroxy-1-(3-methylbutyl)-2-oxo-1,2-dihydro-1,8-naphthyridin-3-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl]methanesulfonamide	-	Hepacivirus C
2.7.7.48	N2-[3-[4-hydroxy-1-(3-methylbutyl)-2-oxo-1,2-dihydro-1,8-naphthyridin-3-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl]glycinamide	-	Hepacivirus C
2.7.7.48	[(1R)-5-cyano-8-methyl-1-propyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl]acetic acid	-	Hepacivirus C
2.7.7.48	[(1R)-8-chloro-5-ethyl-1-propyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl]acetic acid	-	Hepacivirus C
2.7.7.48	[(1S)-5-cyano-8-methyl-1-(1-methylpropyl)-7-[2-(1H-pyrazol-1-yl)ethoxy]-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl]acetic acid	-	Hepacivirus C

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2.7.7.48	nucleoside triphosphate + RNAn	Hepacivirus C	NS5B RdRp is essential for viral replication	diphosphate + RNAn+1	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.7.7.48	Hepacivirus C	-	-	-
2.7.7.48	Measles morbillivirus	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.7.7.48	nucleoside triphosphate + RNAn	-	Hepacivirus C	diphosphate + RNAn+1	-	?
2.7.7.48	nucleoside triphosphate + RNAn	NS5B RdRp is essential for viral replication	Hepacivirus C	diphosphate + RNAn+1	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
2.7.7.48	NS5B RdRp	-	Hepacivirus C
2.7.7.48	NS5B RNA-dependent RNA polymerase	-	Hepacivirus C

IC50 Value

EC Number	IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor
2.7.7.48	0.0000003	-	polymerase from 1 b genotype	Hepacivirus C	A-837093
2.7.7.48	0.0000007	-	polymerase from 1 b genotype	Hepacivirus C	A-837093
2.7.7.48	0.000002	-	-	Hepacivirus C	[(1S)-5-cyano-8-methyl-1-(1-methylpropyl)-7-[2-(1H-pyrazol-1-yl)ethoxy]-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl]acetic acid
2.7.7.48	0.000002	-	polymerase from 1 a genotype	Hepacivirus C	N-[3-[4-hydroxy-1-(3-methylbutyl)-2-oxo-1,2-dihydro-1,8-naphthyridin-3-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl]methanesulfonamide
2.7.7.48	0.000004	-	polymerase from 1 b genotype	Hepacivirus C	N-[3-[1-(cyclobutylamino)-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl]sulfamide
2.7.7.48	0.000005	-	polymerase from 1 a genotype	Hepacivirus C	N-[3-[1-(cyclobutylamino)-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl]sulfamide
2.7.7.48	0.000006	-	-	Hepacivirus C	2-[4-(benzyloxy)phenyl]-3-cyclohexyl-1-[2-(dimethylamino)-2-oxoethyl]-1H-indole-6-carboxylic acid
2.7.7.48	0.000006	-	polymerase from 1 b genotype	Hepacivirus C	N-[3-[4-hydroxy-1-(3-methylbutyl)-2-oxo-1,2-dihydro-1,8-naphthyridin-3-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl]methanesulfonamide
2.7.7.48	0.000009	-	-	Hepacivirus C	2-(4-chlorophenyl)-3-cyclohexyl-1-[2-[4-(diethylamino)piperidin-1-yl]-2-oxoethyl]-1H-indole-6-carboxylic acid
2.7.7.48	0.000009	-	-	Hepacivirus C	13-cyclohexyl-5-(2-piperidin-1-ylethyl)-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepine-10-carboxylic acid
2.7.7.48	0.00001	-	-	Hepacivirus C	1-(2-cyclopropylethyl)-3-(1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)-6-fluoro-4-hydroxyquinolin-2(1H)-one
2.7.7.48	0.000014	-	-	Hepacivirus C	2-[4-([4'-chloro-4-[(4-hydroxypiperidin-1-yl)carbonyl]biphenyl-2-yl]methoxy)-2-fluorophenyl]-1-cyclohexyl-1H-benzimidazole-5-carboxylic acid
2.7.7.48	0.000015	-	-	Hepacivirus C	3-cyclohexyl-2-furan-3-yl-1-[2-oxo-2-(4-pyrrolidin-1-ylpiperidin-1-yl)ethyl]-1H-indole-6-carboxylic acid
2.7.7.48	0.000016	-	-	Hepacivirus C	3-cyclohexyl-2-(3-furyl)-1-methyl-1H-indole-6-carboxylic acid
2.7.7.48	0.000016	-	polymerase from 1 b genotype	Hepacivirus C	2-([3-[4-hydroxy-1-(3-methylbutyl)-2-oxo-1,2-dihydro-1,8-naphthyridin-3-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl]oxy)acetamide
2.7.7.48	0.000017	-	-	Hepacivirus C	2-(4-[[4'-chloro-4-(2-oxopyrrolidin-1-yl)biphenyl-2-yl]methoxy]-2-fluorophenyl)-1-cyclohexyl-1H-benzimidazole-5-carboxylic acid
2.7.7.48	0.000017	-	-	Hepacivirus C	3-(benzyloxy)-13-cyclohexyl-6,7-dihydroindolo[1,2-d][1,4]benzoxazepine-10-carboxylic acid
2.7.7.48	0.000018	-	-	Hepacivirus C	2-([3-[1-(2-cyclopropylethyl)-6-fluoro-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl]oxy)acetamide
2.7.7.48	0.000018	-	-	Hepacivirus C	3-cyclohexyl-1-[2-(dimethylamino)-2-oxoethyl]-2-(4-methoxyphenyl)-1H-indole-6-carboxylic acid
2.7.7.48	0.000018	-	-	Hepacivirus C	3-cyclohexyl-1-(2-[methyl[(1-methylpiperidin-3-yl)methyl]amino]-2-oxoethyl)-2-phenyl-1H-indole-6-carboxylic acid
2.7.7.48	0.000019	-	-	Hepacivirus C	(4S,5R)-1-[(4-tert-butyl-3-methoxyphenyl)carbonyl]-4-methoxy-2-(2-methylpropyl)-5-(1,3-thiazol-2-yl)-L-proline
2.7.7.48	0.000021	-	dihedral angle between the C2-aryl group and the indole ring is 46°	Hepacivirus C	13-cyclohexyl-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepine-10-carboxylic acid
2.7.7.48	0.000026	-	dihedral angle between the C2-aryl group and the indole ring is 43°	Hepacivirus C	13-cyclohexyl-6,7-dihydroindolo[1,2-d][1,4]benzoxazepine-10-carboxylic acid
2.7.7.48	0.000027	-	-	Hepacivirus C	5-(carboxymethoxy)-N-[(1-cyclohexyl-2-furan-3-yl-1H-benzimidazol-5-yl)carbonyl]-L-tryptophan
2.7.7.48	0.00003	-	-	Hepacivirus C	5,6-dihydroxy-2-[4-(([(1-naphthylsulfonyl)amino]carbonyl)amino)-3-thienyl]pyrimidine-4-carboxylic acid
2.7.7.48	0.00003	-	-	Hepacivirus C	3-cyclohexyl-2-(3-furyl)-1H-indole-6-carboxylic acid
2.7.7.48	0.00003	-	-	Hepacivirus C	3-cyclohexyl-1-(2-oxo-2-piperidin-1-ylethyl)-2-phenyl-1H-indole-6-carboxylic acid
2.7.7.48	0.000032	-	-	Hepacivirus C	3-(1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)-4-hydroxy-1-(3-methylbutyl)quinolin-2(1H)-one
2.7.7.48	0.000034	-	polymerase from 1 b genotype	Hepacivirus C	N2-[3-[4-hydroxy-1-(3-methylbutyl)-2-oxo-1,2-dihydro-1,8-naphthyridin-3-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl]glycinamide
2.7.7.48	0.000038	-	-	Hepacivirus C	6-[2-(3-chloro-4-methoxyphenyl)ethyl]-6-cyclopentyl-4-hydroxy-3-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]-5,6-dihydro-2H-pyran-2-one
2.7.7.48	0.000038	-	dihedral angle between the C2-aryl group and the indole ring is 56°	Hepacivirus C	13-cyclohexyl-6,7-dihydroindolo[1,2-d][1,4]benzothiazepine-10-carboxylic acid
2.7.7.48	0.000046	-	-	Hepacivirus C	3-cyclohexyl-2-phenyl-1H-indole-6-carboxylic acid
2.7.7.48	0.000046	-	-	Hepacivirus C	N-[(13-cyclohexyl-6,7-dihydroindolo[1,2-d][1,4]benzoxazepin-10-yl)carbonyl]-2-methylalanine
2.7.7.48	0.000046	-	polymerase from 1 a genotype	Hepacivirus C	2-([3-[4-hydroxy-1-(3-methylbutyl)-2-oxo-1,2-dihydro-1,8-naphthyridin-3-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl]oxy)acetamide
2.7.7.48	0.000047	-	dihedral angle between the C2-aryl group and the indole ring is 61°	Hepacivirus C	14-cyclohexyl-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic acid
2.7.7.48	0.000055	-	-	Hepacivirus C	(2E)-3-(4-[[(1-[[(1-cyclohexyl-2-furan-3-yl-1H-benzimidazol-5-yl)carbonyl]amino]cyclobutyl)carbonyl]amino]phenyl)prop-2-enoic acid
2.7.7.48	0.000055	-	-	Hepacivirus C	(5-cyano-6-fluoro-8-methyl-1-propyl-3,4-dihydro-1H-[1]benzothieno[2,3-c]pyran-1-yl)acetic acid
2.7.7.48	0.00006	-	-	Hepacivirus C	3-cyclohexyl-1-[2-(dimethylamino)-2-oxoethyl]-2-phenyl-1H-indole-6-carboxylic acid
2.7.7.48	0.00006	-	-	Hepacivirus C	6-cyclohexyl-4-[2-(dimethylamino)-2-oxoethyl]-5-phenyl-4H-thieno[3,2-b]pyrrole-2-carboxylic acid
2.7.7.48	0.00007	-	-	Hepacivirus C	6-cyclohexyl-5-phenyl-4H-thieno[3,2-b]pyrrole-2-carboxylic acid
2.7.7.48	0.000077	-	dihedral angle between the C2-aryl group and the indole ring is 53°	Hepacivirus C	13-cyclohexyl-6,7-dihydro-5H-indolo[2,1-a][2]benzazepine-10-carboxylic acid
2.7.7.48	0.00008	-	-	Hepacivirus C	(2S)-1-[(3,4,5-trichloro-2-hydroxyphenyl)sulfonyl]pyrrolidine-2-carboxylic acid
2.7.7.48	0.0001	-	-	Hepacivirus C	2-amino-7-(2-C-methyl-beta-D-ribofuranosyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one
2.7.7.48	0.0001	-	-	Hepacivirus C	(2Z)-2-(benzoylamino)-3-[4-(2-bromophenoxy)phenyl]acrylic acid
2.7.7.48	0.0001	-	-	Hepacivirus C	3-cyclohexyl-2-furan-3-yl-N-[(1S)-2-(5-hydroxy-1H-indol-3-yl)-1-(1,3-thiazol-4-yl)ethyl]-1-methyl-1H-indole-6-carboxamide
2.7.7.48	0.00011	-	polymerase from 1 b genotype	Hepacivirus C	1-(cyclobutylamino)-3-(1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)-4-hydroxyquinolin-2(1H)-one
2.7.7.48	0.00012	-	-	Hepacivirus C	7-(2-C-methyl-beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
2.7.7.48	0.00012	-	-	Hepacivirus C	2-(4-benzylphenyl)-3-cyclohexyl-1-methyl-1H-indole-6-carboxylic acid
2.7.7.48	0.00013	-	-	Hepacivirus C	2'-C-methylguanosine
2.7.7.48	0.00014	-	dihedral angle between the C2-aryl group and the indole ring is 24°	Hepacivirus C	12-cyclohexylindolo[1,2-c][1,3]benzoxazine-9-carboxylic acid
2.7.7.48	0.00015	-	-	Hepacivirus C	3-cyclohexyl-2-phenyl-1H-pyrrolo[2,3-b]pyridine-6-carboxylic acid
2.7.7.48	0.00019	-	-	Hepacivirus C	(2S,4S,5R)-2-(2-methylpropyl)-5-thiophen-2-yl-1-[[4-(trifluoromethyl)phenyl]carbonyl]pyrrolidine-2,4-dicarboxylic acid
2.7.7.48	0.0002	-	-	Hepacivirus C	N-[(5Z)-5-((5-[2-chloro-5-(trifluoromethyl)phenyl]-2-furyl)methylene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]benzenesulfonamide
2.7.7.48	0.0002	-	-	Hepacivirus C	5-[(3,5-dichlorophenyl)amino]-3-hydroxyisothiazole-4-carbonitrile
2.7.7.48	0.00027	-	-	Hepacivirus C	5-(4-cyanophenyl)-3-([(2-methylphenyl)sulfonyl]amino)thiophene-2-carboxylic acid
2.7.7.48	0.00028	-	-	Hepacivirus C	N-[(5Z)-5-(3,4-dichlorobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]benzenesulfonamide
2.7.7.48	0.00028	-	polymerase from 1 a genotype	Hepacivirus C	1-(cyclobutylamino)-3-(1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)-4-hydroxyquinolin-2(1H)-one
2.7.7.48	0.0003	-	-	Hepacivirus C	1-cyclohexyl-2-furan-3-yl-N-[(1S)-2-(5-hydroxy-1H-indol-3-yl)-1-(1,3-thiazol-4-yl)ethyl]-1H-benzimidazole-5-carboxamide
2.7.7.48	0.00032	-	-	Hepacivirus C	3-cyclohexyl-1-[2-(dimethylamino)-2-oxoethyl]-2-phenyl-1H-pyrrolo[2,3-b]pyridine-6-carboxylic acid
2.7.7.48	0.00033	-	-	Hepacivirus C	[(1R)-5-cyano-8-methyl-1-propyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl]acetic acid
2.7.7.48	0.0004	-	-	Hepacivirus C	1-cyclohexyl-2-phenyl-1H-indole-5-carboxylic acid
2.7.7.48	0.00044	-	-	Hepacivirus C	N-[(5Z)-5-(4-bromobenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]benzenesulfonamide
2.7.7.48	0.00047	-	polymerase from 1 a genotype	Hepacivirus C	N2-[3-[4-hydroxy-1-(3-methylbutyl)-2-oxo-1,2-dihydro-1,8-naphthyridin-3-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl]glycinamide
2.7.7.48	0.00064	-	-	Hepacivirus C	1-cyclohexyl-2-(4-[[4-(dimethylcarbamoyl)phenyl](phenyl)methoxy]-2-fluorophenyl)-1H-benzimidazole-5-carboxylic acid
2.7.7.48	0.0007	-	-	Hepacivirus C	(2S)-2-[(2,4-dichlorobenzoyl)(3-nitrobenzyl)amino]-3-phenylpropanoic acid
2.7.7.48	0.00076	-	-	Hepacivirus C	5,6-dihydroxy-2-(1,3-thiazol-5-yl)pyrimidine-4-carboxylic acid
2.7.7.48	0.00077	-	-	Hepacivirus C	(2S)-1-[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]pyrrolidine-2-carboxylic acid
2.7.7.48	0.00093	-	-	Hepacivirus C	3-[(4-amino-2-tert-butyl-5-methylphenyl)sulfanyl]-6-cyclopentyl-4-hydroxy-6-[2-(4-hydroxyphenyl)ethyl]-5,6-dihydro-2H-pyran-2-one
2.7.7.48	0.0012	-	-	Hepacivirus C	2'-C-methylcytidine
2.7.7.48	0.0012	-	-	Hepacivirus C	3'-deoxycytidine
2.7.7.48	0.0014	-	-	Hepacivirus C	3-([(2,4-dimethylphenyl)sulfonyl]amino)-5-phenylthiophene-2-carboxylic acid
2.7.7.48	0.0015	-	-	Hepacivirus C	2-(3-[[(2-chlorobenzyl)carbamoyl]amino]thiophen-2-yl)-5,6-dihydroxypyrimidine-4-carboxylic acid
2.7.7.48	0.0015	-	-	Hepacivirus C	3-[[(trans-4-methylcyclohexyl)carbonyl](1-methylethyl)amino]-5-phenylthiophene-2-carboxylic acid
2.7.7.48	0.0016	-	-	Hepacivirus C	1-cyclohexyl-2-(3-furyl)-1H-benzimidazole-5-carboxylic acid
2.7.7.48	0.0017	-	-	Hepacivirus C	N-[(2,4-dichlorophenyl)carbonyl]-N-[3-(trifluoromethyl)benzyl]-L-phenylalanine
2.7.7.48	0.0019	-	-	Hepacivirus C	2'-C-methyladenosine
2.7.7.48	0.0019	-	-	Hepacivirus C	3-cyclohexyl-2-phenyl-1H-pyrrolo[3,2-b]pyridine-6-carboxylic acid
2.7.7.48	0.0021	-	-	Hepacivirus C	(5-cyano-8-methyl-1-propyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl)acetic acid
2.7.7.48	0.0021	-	-	Hepacivirus C	5,8-dichloro-3-propyl-1,2,3,4-tetrahydrocyclopenta[b]indole-3-carboxylic acid
2.7.7.48	0.0021	-	-	Hepacivirus C	4-methyl-N-((5Z)-5-[(5-methyl-2-furyl)methylene]-4-oxo-4,5-dihydro-1,3-thiazol-2-yl)benzenesulfonamide
2.7.7.48	0.0026	-	-	Hepacivirus C	5,6-dihydroxy-2-(2-thienyl)pyrimidine-4-carboxylic acid
2.7.7.48	0.0027	-	-	Hepacivirus C	N-[(Z)-2-[4-(2-bromophenoxy)phenyl]-1-[(2-hydroxyethyl)carbamoyl]ethenyl]benzamide
2.7.7.48	0.003	-	-	Hepacivirus C	[(1R)-8-chloro-5-ethyl-1-propyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl]acetic acid
2.7.7.48	0.003	-	-	Hepacivirus C	(2S)-(((5Z)-5-[(5-ethyl-2-furyl)methylene]-4-oxo-4,5-dihydro-1,3-thiazol-2-yl)amino)(4-fluorophenyl)acetic acid
2.7.7.48	0.0031	-	-	Hepacivirus C	(2S)-1-[(2-amino-4-chloro-5-methylphenyl)sulfonyl]pyrrolidine-2-carboxylic acid
2.7.7.48	0.0032	-	-	Hepacivirus C	2-[4-(benzyloxy)phenyl]-1-cyclopentyl-1H-benzimidazole-5-carboxylic acid
2.7.7.48	0.0038	-	-	Hepacivirus C	2'-O-methylcytidine
2.7.7.48	0.0048	-	-	Hepacivirus C	3-cyclohexyl-2-phenylquinoline-6-carboxylic acid
2.7.7.48	0.0059	-	-	Hepacivirus C	5-([3,5-bis(trifluoromethyl)phenyl]amino)-3-hydroxyisothiazole-4-carbonitrile
2.7.7.48	0.0065	-	-	Hepacivirus C	1-cyclohexyl-2-phenyl-1H-benzimidazole-5-carboxylic acid
2.7.7.48	0.0067	-	-	Hepacivirus C	(2Z)-2-(benzoylamino)-3-(5-phenyl-2-furyl)acrylic acid
2.7.7.48	0.008	-	-	Hepacivirus C	3-(isopropyl[(4-methylphenyl)sulfonyl]amino)-5-phenylthiophene-2-carboxylic acid
2.7.7.48	0.012	-	-	Hepacivirus C	3-([(4-chloro-2,5-dimethylphenyl)sulfonyl]amino)-5-phenylthiophene-2-carboxamide
2.7.7.48	0.0138	-	-	Hepacivirus C	3-cyclohexyl-2-phenyl-3H-thieno[2,3-d]imidazole-5-carboxylic acid
2.7.7.48	0.03	-	-	Hepacivirus C	5,6-dihydroxy-2-phenylpyrimidine-4-carboxylic acid