EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.5.1.60 | NE10790 | a weak bisphosphonate inhibitor | Rattus norvegicus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.5.1.60 | additional information | - |
additional information | kinetics | Rattus norvegicus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.5.1.60 | geranylgeranyl diphosphate + Rab protein | Rattus norvegicus | - |
S-geranylgeranyl-Rab protein + diphosphate | - |
? | |
2.5.1.60 | additional information | Rattus norvegicus | RabGGTase, which prenylates more than 60 members of the Rab GTPase family, can act on its protein substrates only when they are complexed to an additional factor termed REP, Rab escort protein | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.5.1.60 | Rattus norvegicus | - |
- |
- |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
2.5.1.60 | additional information | - |
development of a continuous fluorometric assay using a protein fluorescence amplifier, overview | Rattus norvegicus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.5.1.60 | geranylgeranyl diphosphate + Rab protein | - |
Rattus norvegicus | S-geranylgeranyl-Rab protein + diphosphate | - |
? | |
2.5.1.60 | geranylgeranyl diphosphate + Rab7 protein | the N-terminal Cys207 is preferred to Cys205, activity with Rab7 mutants, overview | Rattus norvegicus | S-geranylgeranyl-Rab7 protein + diphosphate | - |
? | |
2.5.1.60 | additional information | RabGGTase, which prenylates more than 60 members of the Rab GTPase family, can act on its protein substrates only when they are complexed to an additional factor termed REP, Rab escort protein | Rattus norvegicus | ? | - |
? | |
2.5.1.60 | [3,7,11-trimethyl-12-(7-nitrobenzo[1,2,5]oxadiazo-4-ylamino)dodeca-2,6,10-trien-1] diphosphate + Rab7 protein | i.e. NBD-FPP, a fluorescent analogue of geranylgeranyl diphosphate, which is a lipid donor for RabGGTase | Rattus norvegicus | ? | product is mono-NBD-farnesylated Rab7:REP-1 complex | ? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.5.1.60 | Rab geranylgeranyltransferase | - |
Rattus norvegicus |
2.5.1.60 | RabGGTase | - |
Rattus norvegicus |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.5.1.60 | 37 | - |
assay at | Rattus norvegicus |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.5.1.60 | 0.013 | - |
Rab protein | pH 7.2, 37°C | Rattus norvegicus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.5.1.60 | 7.2 | - |
assay at | Rattus norvegicus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.5.1.60 | additional information | RabGGTase can act on its protein substrates only when they are complexed to an additional factor termed REP, Rab escort protein | Rattus norvegicus |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.5.1.60 | additional information | - |
additional information | inhibition kinetics | Rattus norvegicus |