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Literature summary extracted from

  • Drobna, Z.; Xing, W.; Thomas, D.J.; Styblo, M.
    shRNA silencing of AS3MT expression minimizes arsenic methylation capacity of HepG2 cells (2006), Chem. Res. Toxicol., 19, 894-898.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.137 S-adenosyl-L-methionine + arsenite Homo sapiens hAS3MT is the key enzyme in the pathway for methylation of iAs in human hepatic cells S-adenosyl-L-homocysteine + methylarsonate
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 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.137 Homo sapiens
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-
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.137 Hep-G2 cell in a stable clonal HepG2/A cell line, AS3MT mRNA and protein levels are reduced by 83 and 88%, respectively. The capacity to methylate inorganic arsenic decreases by 70% Homo sapiens
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.137 S-adenosyl-L-methionine + arsenite
-
 Homo sapiens S-adenosyl-L-homocysteine + methylarsonate
-
 ?
2.1.1.137 S-adenosyl-L-methionine + arsenite hAS3MT is the key enzyme in the pathway for methylation of iAs in human hepatic cells Homo sapiens S-adenosyl-L-homocysteine + methylarsonate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.137 arsenic (+3 oxidation state) methyltransferase
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 Homo sapiens
2.1.1.137 hAS3MT
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 Homo sapiens