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Literature summary extracted from

  • Whalen, E.J.; Foster, M.W.; Matsumoto, A.; Ozawa, K.; Violin, J.D.; Que, L.G.; Nelson, C.D.; Benhar, M.; Keys, J.R.; Rockman, H.A.; Koch, W.J.; Daaka, Y.; Lefkowitz, R.J.; Stamler, J.S.
    Regulation of beta-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2 (2007), Cell, 129, 511-522.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.15 additional information quantitative determination of S-nitrosylation of GRK2 by the biotin-switch assay Homo sapiens
2.7.11.15 additional information quantitative determination of S-nitrosylation of GRK2 by the biotin-switch assay Mus musculus
2.7.11.15 nitric oxide inhibits GRK2 by S-nitrosylation at Cys340, regulatory function of S-nitrosylation Homo sapiens
2.7.11.15 nitric oxide inhibits GRK2 by S-nitrosylation at Cys340, regulatory function of S-nitrosylation Mus musculus
2.7.11.15 S-nitrosothiols inhibit GRK2 by S-nitrosylation at Cys340, regulatory function of S-nitrosylation Homo sapiens
2.7.11.15 S-nitrosothiols inhibit GRK2 by S-nitrosylation at Cys340, regulatory function of S-nitrosylation Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.15 membrane
-
 Mus musculus 16020
-
2.7.11.15 membrane
-
 Homo sapiens 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.15 Mg2+
-
 Mus musculus
2.7.11.15 Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.15 ATP + beta-adrenergic receptor Mus musculus the enzyme is involved in regulation of the beta-adrenergic receptor signaling by inhibiting arrestin recruitment to the receptor and subsequent desensitization and internalization, regulation of GRK2 by S-nitrosylation, molecular mechanism, overview ADP + phosphorylated beta-adrenergic receptor
-
 ?
2.7.11.15 ATP + beta-adrenergic receptor Homo sapiens the enzyme is involved in regulation of the beta-adrenergic receptor signaling by inhibiting arrestin recruitment to the receptor and subsequent desensitization and internalization, regulation of GRK2 by S-nitrosylation, molecular mechanism, overview ADP + phosphorylated beta-adrenergic receptor
-
 ?
2.7.11.15 ATP + rhodopsin Mus musculus
-
 ADP + phosphorylated rhodopsin
-
 ?
2.7.11.15 ATP + rhodopsin Homo sapiens
-
 ADP + phosphorylated rhodopsin
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.15 Homo sapiens
-
-
-
2.7.11.15 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.15 HEK-293 cell
-
 Homo sapiens
-
2.7.11.15 lung
-
 Mus musculus
-
2.7.11.15 U2-OS cell an osteosarcoma cell line Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.15 ATP + beta-adrenergic receptor the enzyme is involved in regulation of the beta-adrenergic receptor signaling by inhibiting arrestin recruitment to the receptor and subsequent desensitization and internalization, regulation of GRK2 by S-nitrosylation, molecular mechanism, overview Mus musculus ADP + phosphorylated beta-adrenergic receptor
-
 ?
2.7.11.15 ATP + beta-adrenergic receptor the enzyme is involved in regulation of the beta-adrenergic receptor signaling by inhibiting arrestin recruitment to the receptor and subsequent desensitization and internalization, regulation of GRK2 by S-nitrosylation, molecular mechanism, overview Homo sapiens ADP + phosphorylated beta-adrenergic receptor
-
 ?
2.7.11.15 ATP + beta-adrenergic receptor mapping of S-nitrosylation sites and regulatory locus in GRK2 Mus musculus ADP + phosphorylated beta-adrenergic receptor
-
 ?
2.7.11.15 ATP + beta-adrenergic receptor recombinantly expressed beta-adrenergic receptor in U2-OS cells, mapping of S-nitrosylation sites and regulatory locus in GRK2 Homo sapiens ADP + phosphorylated beta-adrenergic receptor
-
 ?
2.7.11.15 ATP + rhodopsin
-
 Mus musculus ADP + phosphorylated rhodopsin
-
 ?
2.7.11.15 ATP + rhodopsin
-
 Homo sapiens ADP + phosphorylated rhodopsin
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.15 G-protein-coupled receptor kinase 2
-
 Mus musculus
2.7.11.15 G-protein-coupled receptor kinase 2
-
 Homo sapiens
2.7.11.15 GRK2
-
 Mus musculus
2.7.11.15 GRK2
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.15 ATP
-
 Mus musculus
2.7.11.15 ATP
-
 Homo sapiens