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Literature summary extracted from

  • Lu, J.; Papp, L.V.; Fang, J.; Rodriguez-Nieto, S.; Zhivotovsky, B.; Holmgren, A.
    Inhibition of Mammalian thioredoxin reductase by some flavonoids: implications for myricetin and quercetin anticancer activity (2006), Cancer Res., 66, 4410-4418.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.8.1.9 U498C specific activity of 50% of wild-type enzyme Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.8.1.9 myricetin 0.05 mM, strong inhibitory effect, IC50: 0.62 mM Rattus norvegicus
1.8.1.9 quercetin 0.05 mM, strong inhibitory effect, IC50: 0.97 mM Rattus norvegicus
1.8.1.9 reactive oxygen species 0.1 mM, ROS generated by xanthine/xanthine oxidase enhance the inhibitory effect of flavonoids Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.8.1.9 57000
-
 2 * 57000, SDS-PAGE Rattus norvegicus
1.8.1.9 115000
-
 SDS-PAGE Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.9 Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.9 5,5'-dithiobis(2-nitrobenzoic acid) + NADPH
-
 Rattus norvegicus 2-nitro-5-thiobenzoate + NADP+
-
 ?
1.8.1.9 thioredoxin + NADP+
-
 Rattus norvegicus thioredoxin disulfide + NADPH
-
 ?

Subunits

EC Number Subunits Comment Organism
1.8.1.9 dimer 2 * 57000, SDS-PAGE Rattus norvegicus

Synonyms

EC Number Synonyms Comment Organism
1.8.1.9 thioredoxin reductase
-
 Rattus norvegicus
1.8.1.9 TrxR
-
 Rattus norvegicus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.8.1.9 0.62
-
 0.05 mM, strong inhibitory effect, IC50: 0.62 mM Rattus norvegicus myricetin
1.8.1.9 0.97
-
 0.05 mM, strong inhibitory effect, IC50: 0.97 mM Rattus norvegicus quercetin