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Literature summary extracted from

  • Degtyar, V.G.; Babkina, T.V.; Kazantseva, I.A.; Morozov, A.P.; Trapeznikova, M.F.; Kushlinskii, N.E.
    Reductase activity of 17beta-hydroxysteroid oxidoreductase in prostatic tumors of different histological structure (2005), Bull. Exp. Biol. Med., 139, 715-717.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.51 androst-4-ene-3,17-dione + NADPH Homo sapiens
-
 testosterone + NADP+
-
 ?
1.1.1.51 androstane-3,17-dione + NADPH Homo sapiens
-
 dihydrotestosterone + NADP+
-
 ?
1.1.1.51 additional information Homo sapiens activity of the enzyme is associated with the mechanism of prostatic regulation by androgens after castration, which is important in prostate cancer ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.51 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.51 prostate cancer cell cancer and bening hyperplasia, protstaic intraepithelial neoplasia, enzyme distribution, overview Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.51 additional information
-
 determination of serum and tumor tissue concentrations of steroids in prostate cancer patients, overview Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.51 androst-4-ene-3,17-dione + NADPH
-
 Homo sapiens testosterone + NADP+
-
 ?
1.1.1.51 androstane-3,17-dione + NADPH
-
 Homo sapiens dihydrotestosterone + NADP+
-
 ?
1.1.1.51 additional information activity of the enzyme is associated with the mechanism of prostatic regulation by androgens after castration, which is important in prostate cancer Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.51 17beta-HSOR
-
 Homo sapiens
1.1.1.51 17beta-hydroxysteroid oxidoreductase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.51 NADPH
-
 Homo sapiens