BRENDA - Enzyme Database

Inhibitory effects of various beverages on human recombinant sulfotransferase isoforms SULT1A1 and SULT1A3

Nishimuta, H.; Ohtani, H.; Tsujimoto, M.; Ogura, K.; Hiratsuka, A.; Sawada, Y.; Biopharm. Drug Dispos. 28, 491-500 (2007)

Data extracted from this reference:

Cloned(Commentary)
EC Number
Commentary
Organism
2.8.2.1
expression of His-tagged sulfotransferase in Escherichia coli BL21-DE3; expression of His-tagged sulfotransferase in Escherichia coli BL21-DE3; expression of His-tagged SULT1A1 in Escherichia coli; expression of His-tagged SULT1A3 in Escherichia coli
Homo sapiens
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.8.2.1
(+)-catechin
;
Homo sapiens
2.8.2.1
(-)-epicatechin
; complete inhibition of SULT1A1
Homo sapiens
2.8.2.1
(-)-epicatechin gallate
almost complete inhibition of SULT1A1; almost complete inhibition of SULT1A3
Homo sapiens
2.8.2.1
(-)-epigallocatechin
; complete inhibition of SULT1A1
Homo sapiens
2.8.2.1
(-)-epigallocatechin gallate
almost complete inhibition of SULT1A1; almost complete inhibition of SULT1A3
Homo sapiens
2.8.2.1
6',7'-dihydroxybergamottin
; inhibition of SULT1A1; significantly inhibits the activity of SULT1A1
Homo sapiens
2.8.2.1
bergamottin
; inhibition of SULT1A1; inhibition of SULT1A3; significantly inhibits the activity of SULT1A1
Homo sapiens
2.8.2.1
additional information
grapefruit juice and orange juice show a weak inhibition of SULT1A3, green tea, black tea and oolong tea show a good inhibition of SULT1A3; naringin and bergamottin do not inhibit SULT1A1, inhibitory effects of grapefruit juice, orange juice, green tea, black tea and oolong tea and their constituents on the activities of SULT1A1 and SULT1A3, inhibitory action of green tea on SULT1A3 is competitive, while that of black tea and oolong tea is mixed competitive/non-competitive, no mechanism-based inhibition, the mode of inhibition is competitive, overview; naringin does not inhibit SULT1A1, grapefruit juice and orange juice show a good inhibition of SULT1A1, green tea, black tea and oolong tea are also inhibitors of SULT1A1; no inhibition of SULT1A3 by 60,70-dihydroxybergamottin, inhibitory effects of grapefruit juice, orange juice, green tea, black tea and oolong tea and their constituents on the activities of SULT1A1 and SULT1A3, inhibitory action of green tea on SULT1A3 is competitive, while that of black tea and oolong tea is mixed competitive/non-competitive, no mechanism-based inhibition, the mode of inhibition is competitive, overview
Homo sapiens
2.8.2.1
naringenin
; inhibition of SULT1A1; partial inhibition of SULT1A3; significantly inhibits the activity of SULT1A1
Homo sapiens
2.8.2.1
naringin
inhibition of SULT1A3
Homo sapiens
2.8.2.1
nobiletin
belongs to the most potent inhibitors; belongs to the most potent inhibitors, significantly inhibits the activity of SULT1A1; complete inhibition of SULT1A1; partial inhibition of SULT1A3
Homo sapiens
2.8.2.1
quercetin
belongs to the most potent inhibitors; belongs to the most potent inhibitors, significantly inhibits the activity of SULT1A1; complete inhibition of SULT1A1; partial inhibition of SULT1A3
Homo sapiens
2.8.2.1
tangeretin
belongs to the most potent inhibitors; belongs to the most potent inhibitors, significantly inhibits the activity of SULT1A1; complete inhibition of SULT1A1; partial inhibition of SULT1A3
Homo sapiens
2.8.2.1
theaflavin
complete inhibition of SULT1A1; strong inhibition of SULT1A3
Homo sapiens
2.8.2.1
thearubigin
complete inhibition of SULT1A1; strong inhibition of SULT1A3
Homo sapiens
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.8.2.1
cytosol
;
Homo sapiens
5829
-
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.8.2.1
3'-phosphoadenylyl sulfate + a phenol
Homo sapiens
-
adenosine 3',5'-bisphosphate + an aryl sulfate
-
-
?
2.8.2.1
additional information
Homo sapiens
SULT1A1 plays important roles in the presystemic inactivation of b2 agonists in the liver
?
-
-
-
2.8.2.1
additional information
Homo sapiens
SULT1A3 plays important roles in the presystemic inactivation of b2 agonists in the intestine
?
-
-
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.8.2.1
Homo sapiens
P0DMM9
; SULT1A3; SULT1A3
-
2.8.2.1
Homo sapiens
P50225
; SULT1A1; SULT1A1
-
Purification (Commentary)
EC Number
Commentary
Organism
2.8.2.1
one-step column chromatography, His-binding metal chelation resin column; one-step column chromatography, His-binding metal chelation resin column; recombinant His-tagged SULT1A1 from Escherichia coli by nickel affinity chromatography; recombinant His-tagged SULT1A3 from Escherichia coli by nickel affinity chromatography
Homo sapiens
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.8.2.1
intestine
SULT1A3
Homo sapiens
-
2.8.2.1
liver
SULT1A1
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.8.2.1
3'-phosphoadenylyl sulfate + 4-nitrophenol
-
672630
Homo sapiens
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + a phenol
-
672630
Homo sapiens
adenosine 3',5'-bisphosphate + an aryl sulfate
-
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + dopamine
as dopamine hydrochloride
672630
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + dopamine
-
672630
Homo sapiens
adenosine 3',5'-bisphosphate + dopamine sulfate
-
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + fenoterol
as fenoterol hydrobromide
672630
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + isoproterenol
as isoproterenol hydrochloride
672630
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + isoproterenol
as isoproterenol hydrochloride
672630
Homo sapiens
adenosine 3',5'-bisphosphate + isoproterenol sulfate
-
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + p-nitrophenol
-
672630
Homo sapiens
adenosine 3',5'-bisphosphate + p-nitrophenyl sulfate
-
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + ritodrine
as ritodrine hydrochloride
672630
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + salbutamol
as salbutamol hemisulfate
672630
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + terbutaline
as terbutaline hemisulfate
672630
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.1
additional information
SULT1A1 plays important roles in the presystemic inactivation of b2 agonists in the liver
672630
Homo sapiens
?
-
-
-
-
2.8.2.1
additional information
SULT1A3 plays important roles in the presystemic inactivation of b2 agonists in the intestine
672630
Homo sapiens
?
-
-
-
-
Temperature Optimum [C]
EC Number
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
2.8.2.1
37
-
assay at; assay at
Homo sapiens
pH Optimum
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
2.8.2.1
6.8
-
assay at; assay at
Homo sapiens
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
2.8.2.1
expression of His-tagged sulfotransferase in Escherichia coli BL21-DE3; expression of His-tagged SULT1A1 in Escherichia coli
Homo sapiens
2.8.2.1
expression of His-tagged sulfotransferase in Escherichia coli BL21-DE3; expression of His-tagged SULT1A3 in Escherichia coli
Homo sapiens
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.8.2.1
(+)-catechin
-
Homo sapiens
2.8.2.1
(-)-epicatechin
complete inhibition of SULT1A1
Homo sapiens
2.8.2.1
(-)-epicatechin
-
Homo sapiens
2.8.2.1
(-)-epicatechin gallate
almost complete inhibition of SULT1A1
Homo sapiens
2.8.2.1
(-)-epicatechin gallate
almost complete inhibition of SULT1A3
Homo sapiens
2.8.2.1
(-)-epigallocatechin
complete inhibition of SULT1A1
Homo sapiens
2.8.2.1
(-)-epigallocatechin
-
Homo sapiens
2.8.2.1
(-)-epigallocatechin gallate
almost complete inhibition of SULT1A1
Homo sapiens
2.8.2.1
(-)-epigallocatechin gallate
almost complete inhibition of SULT1A3
Homo sapiens
2.8.2.1
6',7'-dihydroxybergamottin
inhibition of SULT1A1; significantly inhibits the activity of SULT1A1
Homo sapiens
2.8.2.1
6',7'-dihydroxybergamottin
-
Homo sapiens
2.8.2.1
bergamottin
inhibition of SULT1A1; significantly inhibits the activity of SULT1A1
Homo sapiens
2.8.2.1
bergamottin
; inhibition of SULT1A3
Homo sapiens
2.8.2.1
additional information
naringin and bergamottin do not inhibit SULT1A1, inhibitory effects of grapefruit juice, orange juice, green tea, black tea and oolong tea and their constituents on the activities of SULT1A1 and SULT1A3, inhibitory action of green tea on SULT1A3 is competitive, while that of black tea and oolong tea is mixed competitive/non-competitive, no mechanism-based inhibition, the mode of inhibition is competitive, overview; naringin does not inhibit SULT1A1, grapefruit juice and orange juice show a good inhibition of SULT1A1, green tea, black tea and oolong tea are also inhibitors of SULT1A1
Homo sapiens
2.8.2.1
additional information
grapefruit juice and orange juice show a weak inhibition of SULT1A3, green tea, black tea and oolong tea show a good inhibition of SULT1A3; no inhibition of SULT1A3 by 60,70-dihydroxybergamottin, inhibitory effects of grapefruit juice, orange juice, green tea, black tea and oolong tea and their constituents on the activities of SULT1A1 and SULT1A3, inhibitory action of green tea on SULT1A3 is competitive, while that of black tea and oolong tea is mixed competitive/non-competitive, no mechanism-based inhibition, the mode of inhibition is competitive, overview
Homo sapiens
2.8.2.1
naringenin
inhibition of SULT1A1; significantly inhibits the activity of SULT1A1
Homo sapiens
2.8.2.1
naringenin
; partial inhibition of SULT1A3
Homo sapiens
2.8.2.1
naringin
inhibition of SULT1A3
Homo sapiens
2.8.2.1
nobiletin
belongs to the most potent inhibitors, significantly inhibits the activity of SULT1A1; complete inhibition of SULT1A1
Homo sapiens
2.8.2.1
nobiletin
belongs to the most potent inhibitors; partial inhibition of SULT1A3
Homo sapiens
2.8.2.1
quercetin
belongs to the most potent inhibitors, significantly inhibits the activity of SULT1A1; complete inhibition of SULT1A1
Homo sapiens
2.8.2.1
quercetin
belongs to the most potent inhibitors; partial inhibition of SULT1A3
Homo sapiens
2.8.2.1
tangeretin
belongs to the most potent inhibitors, significantly inhibits the activity of SULT1A1; complete inhibition of SULT1A1
Homo sapiens
2.8.2.1
tangeretin
belongs to the most potent inhibitors; partial inhibition of SULT1A3
Homo sapiens
2.8.2.1
theaflavin
; complete inhibition of SULT1A1
Homo sapiens
2.8.2.1
theaflavin
; strong inhibition of SULT1A3
Homo sapiens
2.8.2.1
thearubigin
; complete inhibition of SULT1A1
Homo sapiens
2.8.2.1
thearubigin
; strong inhibition of SULT1A3
Homo sapiens
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.8.2.1
cytosol
-
Homo sapiens
5829
-
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.8.2.1
3'-phosphoadenylyl sulfate + a phenol
Homo sapiens
-
adenosine 3',5'-bisphosphate + an aryl sulfate
-
-
?
2.8.2.1
additional information
Homo sapiens
SULT1A1 plays important roles in the presystemic inactivation of b2 agonists in the liver
?
-
-
-
2.8.2.1
additional information
Homo sapiens
SULT1A3 plays important roles in the presystemic inactivation of b2 agonists in the intestine
?
-
-
-
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
2.8.2.1
one-step column chromatography, His-binding metal chelation resin column; recombinant His-tagged SULT1A1 from Escherichia coli by nickel affinity chromatography
Homo sapiens
2.8.2.1
one-step column chromatography, His-binding metal chelation resin column; recombinant His-tagged SULT1A3 from Escherichia coli by nickel affinity chromatography
Homo sapiens
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.8.2.1
intestine
SULT1A3
Homo sapiens
-
2.8.2.1
liver
SULT1A1
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.8.2.1
3'-phosphoadenylyl sulfate + 4-nitrophenol
-
672630
Homo sapiens
adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + a phenol
-
672630
Homo sapiens
adenosine 3',5'-bisphosphate + an aryl sulfate
-
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + dopamine
as dopamine hydrochloride
672630
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + dopamine
-
672630
Homo sapiens
adenosine 3',5'-bisphosphate + dopamine sulfate
-
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + fenoterol
as fenoterol hydrobromide
672630
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + isoproterenol
as isoproterenol hydrochloride
672630
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + isoproterenol
as isoproterenol hydrochloride
672630
Homo sapiens
adenosine 3',5'-bisphosphate + isoproterenol sulfate
-
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + p-nitrophenol
-
672630
Homo sapiens
adenosine 3',5'-bisphosphate + p-nitrophenyl sulfate
-
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + ritodrine
as ritodrine hydrochloride
672630
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + salbutamol
as salbutamol hemisulfate
672630
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.1
3'-phosphoadenylyl sulfate + terbutaline
as terbutaline hemisulfate
672630
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
2.8.2.1
additional information
SULT1A1 plays important roles in the presystemic inactivation of b2 agonists in the liver
672630
Homo sapiens
?
-
-
-
-
2.8.2.1
additional information
SULT1A3 plays important roles in the presystemic inactivation of b2 agonists in the intestine
672630
Homo sapiens
?
-
-
-
-
Temperature Optimum [C] (protein specific)
EC Number
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
2.8.2.1
37
-
assay at
Homo sapiens
pH Optimum (protein specific)
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
2.8.2.1
6.8
-
assay at
Homo sapiens