Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Nishimuta, H.; Ohtani, H.; Tsujimoto, M.; Ogura, K.; Hiratsuka, A.; Sawada, Y.
    Inhibitory effects of various beverages on human recombinant sulfotransferase isoforms SULT1A1 and SULT1A3 (2007), Biopharm. Drug Dispos., 28, 491-500.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.8.2.1 expression of His-tagged sulfotransferase in Escherichia coli BL21-DE3 Homo sapiens
2.8.2.1 expression of His-tagged SULT1A1 in Escherichia coli Homo sapiens
2.8.2.1 expression of His-tagged SULT1A3 in Escherichia coli Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.8.2.1 (+)-catechin
-
Homo sapiens
2.8.2.1 (-)-epicatechin complete inhibition of SULT1A1 Homo sapiens
2.8.2.1 (-)-epicatechin gallate almost complete inhibition of SULT1A1; almost complete inhibition of SULT1A3 Homo sapiens
2.8.2.1 (-)-epigallocatechin complete inhibition of SULT1A1 Homo sapiens
2.8.2.1 (-)-epigallocatechin gallate almost complete inhibition of SULT1A1; almost complete inhibition of SULT1A3 Homo sapiens
2.8.2.1 6',7'-dihydroxybergamottin inhibition of SULT1A1; significantly inhibits the activity of SULT1A1 Homo sapiens
2.8.2.1 bergamottin inhibition of SULT1A1; inhibition of SULT1A3; significantly inhibits the activity of SULT1A1 Homo sapiens
2.8.2.1 additional information grapefruit juice and orange juice show a weak inhibition of SULT1A3, green tea, black tea and oolong tea show a good inhibition of SULT1A3; naringin and bergamottin do not inhibit SULT1A1, inhibitory effects of grapefruit juice, orange juice, green tea, black tea and oolong tea and their constituents on the activities of SULT1A1 and SULT1A3, inhibitory action of green tea on SULT1A3 is competitive, while that of black tea and oolong tea is mixed competitive/non-competitive, no mechanism-based inhibition, the mode of inhibition is competitive, overview; naringin does not inhibit SULT1A1, grapefruit juice and orange juice show a good inhibition of SULT1A1, green tea, black tea and oolong tea are also inhibitors of SULT1A1; no inhibition of SULT1A3 by 60,70-dihydroxybergamottin, inhibitory effects of grapefruit juice, orange juice, green tea, black tea and oolong tea and their constituents on the activities of SULT1A1 and SULT1A3, inhibitory action of green tea on SULT1A3 is competitive, while that of black tea and oolong tea is mixed competitive/non-competitive, no mechanism-based inhibition, the mode of inhibition is competitive, overview Homo sapiens
2.8.2.1 naringenin inhibition of SULT1A1; partial inhibition of SULT1A3; significantly inhibits the activity of SULT1A1 Homo sapiens
2.8.2.1 naringin inhibition of SULT1A3 Homo sapiens
2.8.2.1 nobiletin belongs to the most potent inhibitors; belongs to the most potent inhibitors, significantly inhibits the activity of SULT1A1; complete inhibition of SULT1A1; partial inhibition of SULT1A3 Homo sapiens
2.8.2.1 quercetin belongs to the most potent inhibitors; belongs to the most potent inhibitors, significantly inhibits the activity of SULT1A1; complete inhibition of SULT1A1; partial inhibition of SULT1A3 Homo sapiens
2.8.2.1 tangeretin belongs to the most potent inhibitors; belongs to the most potent inhibitors, significantly inhibits the activity of SULT1A1; complete inhibition of SULT1A1; partial inhibition of SULT1A3 Homo sapiens
2.8.2.1 theaflavin complete inhibition of SULT1A1; strong inhibition of SULT1A3 Homo sapiens
2.8.2.1 thearubigin complete inhibition of SULT1A1; strong inhibition of SULT1A3 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.8.2.1 cytosol
-
Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.2.1 3'-phosphoadenylyl sulfate + a phenol Homo sapiens
-
adenosine 3',5'-bisphosphate + an aryl sulfate
-
?
2.8.2.1 additional information Homo sapiens SULT1A1 plays important roles in the presystemic inactivation of b2 agonists in the liver ?
-
?
2.8.2.1 additional information Homo sapiens SULT1A3 plays important roles in the presystemic inactivation of b2 agonists in the intestine ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.1 Homo sapiens P0DMM9
-
-
2.8.2.1 Homo sapiens P0DMM9 SULT1A3; SULT1A3
-
2.8.2.1 Homo sapiens P50225
-
-
2.8.2.1 Homo sapiens P50225 SULT1A1; SULT1A1
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.8.2.1 one-step column chromatography, His-binding metal chelation resin column Homo sapiens
2.8.2.1 recombinant His-tagged SULT1A1 from Escherichia coli by nickel affinity chromatography Homo sapiens
2.8.2.1 recombinant His-tagged SULT1A3 from Escherichia coli by nickel affinity chromatography Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.2.1 intestine SULT1A3 Homo sapiens
-
2.8.2.1 liver SULT1A1 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.1 3'-phosphoadenylyl sulfate + 4-nitrophenol
-
Homo sapiens adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
?
2.8.2.1 3'-phosphoadenylyl sulfate + a phenol
-
Homo sapiens adenosine 3',5'-bisphosphate + an aryl sulfate
-
?
2.8.2.1 3'-phosphoadenylyl sulfate + dopamine as dopamine hydrochloride Homo sapiens adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.1 3'-phosphoadenylyl sulfate + dopamine
-
Homo sapiens adenosine 3',5'-bisphosphate + dopamine sulfate
-
?
2.8.2.1 3'-phosphoadenylyl sulfate + fenoterol as fenoterol hydrobromide Homo sapiens adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.1 3'-phosphoadenylyl sulfate + isoproterenol as isoproterenol hydrochloride Homo sapiens adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.1 3'-phosphoadenylyl sulfate + isoproterenol as isoproterenol hydrochloride Homo sapiens adenosine 3',5'-bisphosphate + isoproterenol sulfate
-
?
2.8.2.1 3'-phosphoadenylyl sulfate + p-nitrophenol
-
Homo sapiens adenosine 3',5'-bisphosphate + p-nitrophenyl sulfate
-
?
2.8.2.1 3'-phosphoadenylyl sulfate + ritodrine as ritodrine hydrochloride Homo sapiens adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.1 3'-phosphoadenylyl sulfate + salbutamol as salbutamol hemisulfate Homo sapiens adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.1 3'-phosphoadenylyl sulfate + terbutaline as terbutaline hemisulfate Homo sapiens adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.1 additional information SULT1A1 plays important roles in the presystemic inactivation of b2 agonists in the liver Homo sapiens ?
-
?
2.8.2.1 additional information SULT1A3 plays important roles in the presystemic inactivation of b2 agonists in the intestine Homo sapiens ?
-
?

Synonyms

EC Number Synonyms Comment Organism
2.8.2.1 SULT1A1
-
Homo sapiens
2.8.2.1 SULT1A3
-
Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.8.2.1 37
-
assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.8.2.1 6.8
-
assay at Homo sapiens