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Literature summary extracted from

  • Deschamps, J.D.; Kenyon, V.A.; Holman, T.R.
    Baicalein is a potent in vitro inhibitor against both reticulocyte 15-human and platelet 12-human lipoxygenases (2006), Bioorg. Med. Chem., 14, 4295-4301.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.33 apigenin IC50: 0.0034 mM without Triton X-100, IC50: 0.0003 mM in the presence of 0.01% Triton X-100 Homo sapiens
1.13.11.33 baicalein potent inhibitor, IC50: 0.0016 mM without Triton X-100, IC50: 0.038 mM in the presence of 0.01% Triton X-100 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.33 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.33 reticulocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.33 arachidonate + O2
-
 Homo sapiens (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.33 15-hLO-1
-
 Homo sapiens
1.13.11.33 15-lipoxygenase-1
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.13.11.33 0.00018
-
 baicalein
-
 Homo sapiens
1.13.11.33 0.0011
-
 baicalein in the presence of 0.01% Triton X-100 Homo sapiens
1.13.11.33 0.002
-
 apigenin
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.13.11.33 0.0003 100 IC50: 0.0034 mM without Triton X-100, IC50: 0.0003 mM in the presence of 0.01% Triton X-100 Homo sapiens apigenin
1.13.11.33 0.038 100 potent inhibitor, IC50: 0.0016 mM without Triton X-100, IC50: 0.038 mM in the presence of 0.01% Triton X-100 Homo sapiens baicalein