Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Wang, Z.; Silverman, R.B.
    Syntheses and evaluation of fluorinated conformationally restricted analogues of GABA as potential inhibitors of GABA aminotransferase (2006), Bioorg. Med. Chem., 14, 2242-2252.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.6.1.19 (+/-)-(1S,2R,4S,5S)-4-amino-6,6-difluorobicyclo[3.1.0]hexane-2-carboxylic acid 10 mM, weak, reversible inhibitor Sus scrofa
2.6.1.19 (+/-)-(1S,2S,4S,5S)-4-amino-6,6-difluorobicyclo[3.1.0]hexane-2-carboxylic acid 10 mM, weak, reversible inhibitor Sus scrofa
2.6.1.19 3-aminocyclohexanecarboxylic acid 10 mM Sus scrofa
2.6.1.19 4-amino-5-fluoropentanoic acid potent irreversible inhibitor Sus scrofa
2.6.1.19 additional information (+/-)-(1S,3S,4S)-3-amino-4-fluorocyclohexanecarboxylic acid and (cis)-3-amino-5,5-difluorocylcohexanecarboxylic acid are no an inhibitors of GABA-AT at a concentration of 10 mM Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.19 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.6.1.19 brain
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.19 4-aminobutanoate + 2-oxoglutarate
-
 Sus scrofa 4-oxobutanoate + L-glutamate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.6.1.19 GABA-AT
-
 Sus scrofa
2.6.1.19 gamma-aminobutyric acid aminotransferase
-
 Sus scrofa

Cofactor

EC Number Cofactor Comment Organism Structure
2.6.1.19 pyridoxal 5'-phosphate
-
 Sus scrofa