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Literature summary extracted from

  • Viezeliene, D.; Rodovicius, H.; Ivanov, L.
    Effect of aluminum ions on the activities of tRNALeu and leucyl-tRNA synthetase in mouse liver in vivo and in vitro (2006), Biologija (Vilnius), 4, 28-30.
No PubMed abstract available

Activating Compound

EC Number Activating Compound Comment Organism Structure
6.1.1.4 Al3+ in vivo acceptor activity of tRNALeu is decreased by 23% thereby the leucyl-tRNA synthetase activity is increased by 20%, overview Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.1.1.4 Al3+ in vitro the enzyme is inhibited by 40% at 0.04 mM, Al3+ inhibits the enzyme in vivo and in vitro, quantitative analysis, in vivo acceptor activity of tRNALeu is decreased by 23% thereby the leucyl-tRNA synthetase activity is increased by 20%, overview Mus musculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.1.1.4 Mg2+
-
 Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.1.1.4 ATP + L-leucine + tRNALeu Mus musculus
-
 AMP + diphosphate + L-leucyl-tRNALeu
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.1.1.4 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.1.1.4 liver
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.1.1.4 ATP + L-leucine + tRNALeu
-
 Mus musculus AMP + diphosphate + L-leucyl-tRNALeu
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.1.1.4 Leucyl-tRNA synthetase
-
 Mus musculus
6.1.1.4 LeuRS
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
6.1.1.4 ATP
-
 Mus musculus