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Literature summary extracted from
- The recent evolution of pentachlorophenol (PCP)-4-monooxygenase (PcpB) and associated pathways for bacterial degradation of PCP (2006), Biodegradation, 18, 525-539.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 1.14.13.50 | additional information | the enzyme can be used for development of a model system for the study of recent evolution of catabolic pathways among bacteria that degrade xenobiotic molecules introduced into the environment during the recent past | Sphingomonas sp. |
| 1.14.13.50 | additional information | the enzyme can be used for development of a model system for the study of recent evolution of catabolic pathways among bacteria that degrade xenobiotic molecules introduced into the environment during the recent past | Sphingobium chlorophenolicum |
| 1.14.13.50 | additional information | the enzyme can be used for development of a model system for the study of recent evolution of catabolic pathways among bacteria that degrade xenobiotic molecules introduced into the environment during the recent past | Mycolicibacterium chlorophenolicum |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.14.13.50 | gene pcpB, DNA and amino acid sequence analysis, phylogenetic analysis | Sphingomonas sp. |
| 1.14.13.50 | gene pcpB, DNA and amino acid sequence analysis, phylogenetic analysis | Sphingobium chlorophenolicum |
| 1.14.13.50 | gene pcpB, DNA and amino acid sequence analysis, phylogenetic analysis | Mycolicibacterium chlorophenolicum |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.13.50 | additional information | Sphingomonas sp. | lateral gene transfer and the origin of the pentachlorophenol pathway, overview | ? | - |
? |  |
| 1.14.13.50 | additional information | Sphingobium chlorophenolicum | lateral gene transfer and the origin of the pentachlorophenol pathway, overview | ? | - |
? | |
| 1.14.13.50 | additional information | Mycolicibacterium chlorophenolicum | lateral gene transfer and the origin of the pentachlorophenol pathway, overview | ? | - |
? | |
| 1.14.13.50 | pentachlorophenol + NADPH + H+ + O2 | Sphingomonas sp. | initial enzyme in the PCP catabolic pathway of numerous sphingomonads, PCP-4-monooxygenase (PcpB), catalyzes the parahydroxylation of PCP to tetrachlorohydroquinone, pentachlorophenol degradation pathway, overview | 2,3,5,6-tetrachlorohydroquinone + NADP+ + chloride + H2O | - |
? | |
| 1.14.13.50 | pentachlorophenol + NADPH + H+ + O2 | Sphingobium chlorophenolicum | initial enzyme in the PCP catabolic pathway of numerous sphingomonads, PCP-4-monooxygenase (PcpB), catalyzes the parahydroxylation of PCP to tetrachlorohydroquinone, pentachlorophenol degradation pathway, overview | 2,3,5,6-tetrachlorohydroquinone + NADP+ + chloride + H2O | - |
? | |
| 1.14.13.50 | pentachlorophenol + NADPH + H+ + O2 | Mycolicibacterium chlorophenolicum | initial enzyme in the PCP catabolic pathway of numerous sphingomonads, PCP-4-monooxygenase (PcpB), catalyzes the parahydroxylation of PCP to tetrachlorohydroquinone, pentachlorophenol degradation pathway, overview | 2,3,5,6-tetrachlorohydroquinone + NADP+ + chloride + H2O | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.13.50 | Mycolicibacterium chlorophenolicum | - |
i.e. Mycobacterium chlorophenolicus, gene pcpB | - |
| 1.14.13.50 | Sphingobium chlorophenolicum | - |
i.e. Pseudomonas sp. RA2 and Pseudomonas sp. SR3, and Arthrobacter sp. strain ATCC 33790, gene pcpB | - |
| 1.14.13.50 | Sphingobium chlorophenolicum | - |
strain ATCC 39723, formerly Flavobacterium and Sphingomonas, gene pcpB | - |
| 1.14.13.50 | Sphingomonas sp. | - |
ssp. UG25 and UG30, gene pcpB | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.13.50 | 2,3,4,6-tetrachlorophenol + NADPH + O2 | - |
Mycolicibacterium chlorophenolicum | ? | - |
? | |
| 1.14.13.50 | 2,3,5,6-tetrachlorophenol + NADPH + O2 | - |
Sphingobium chlorophenolicum | ? | - |
? | |
| 1.14.13.50 | 2,3,5,6-tetrachlorophenol + NADPH + O2 | - |
Mycolicibacterium chlorophenolicum | ? | - |
? | |
| 1.14.13.50 | 2,3,5-trichlorophenol + NADPH + O2 | - |
Mycolicibacterium chlorophenolicum | ? | - |
? | |
| 1.14.13.50 | 2,3,6-trichlorophenol + NADPH + O2 | - |
Sphingobium chlorophenolicum | ? | - |
? | |
| 1.14.13.50 | 2,3,6-trichlorophenol + NADPH + O2 | - |
Mycolicibacterium chlorophenolicum | ? | - |
? | |
| 1.14.13.50 | 2,4,6-trichlorophenol + NADPH + O2 | - |
Sphingobium chlorophenolicum | ? | - |
? | |
| 1.14.13.50 | 2,4-dichlorophenol + NADPH + O2 | - |
Sphingobium chlorophenolicum | ? | - |
? | |
| 1.14.13.50 | 2,4-dinitrophenol + NADPH + O2 | - |
Sphingomonas sp. | ? | - |
? | |
| 1.14.13.50 | 2,6-dichlorophenol + NADPH + O2 | - |
Sphingobium chlorophenolicum | ? | - |
? | |
| 1.14.13.50 | 3,4,5,6-tetrachlorophenol + NADPH + O2 | - |
Mycolicibacterium chlorophenolicum | ? | - |
? | |
| 1.14.13.50 | 3,4,5-trichlorophenol + NADPH + O2 | - |
Mycolicibacterium chlorophenolicum | ? | - |
? | |
| 1.14.13.50 | 3,5-dibromo-4-hydroxybenzonitrile + NADPH + O2 | - |
Sphingobium chlorophenolicum | ? | - |
? | |
| 1.14.13.50 | 4,6-dinitro-o-cresol + NADPH + O2 | - |
Sphingomonas sp. | ? | - |
? | |
| 1.14.13.50 | 4-nitrocatechol + NADPH + O2 | - |
Sphingomonas sp. | ? | - |
? | |
| 1.14.13.50 | 4-nitrophenol + NADPH + O2 | - |
Sphingomonas sp. | ? | - |
? | |
| 1.14.13.50 | chloroguaiacol + NADPH + O2 | - |
Mycolicibacterium chlorophenolicum | ? | - |
? | |
| 1.14.13.50 | additional information | lateral gene transfer and the origin of the pentachlorophenol pathway, overview | Sphingomonas sp. | ? | - |
? | |
| 1.14.13.50 | additional information | lateral gene transfer and the origin of the pentachlorophenol pathway, overview | Sphingobium chlorophenolicum | ? | - |
? | |
| 1.14.13.50 | additional information | lateral gene transfer and the origin of the pentachlorophenol pathway, overview | Mycolicibacterium chlorophenolicum | ? | - |
? | |
| 1.14.13.50 | pentachlorophenol + NADPH + H+ + O2 | - |
Sphingomonas sp. | 2,3,5,6-tetrachlorohydroquinone + NADP+ + chloride + H2O | - |
? | |
| 1.14.13.50 | pentachlorophenol + NADPH + H+ + O2 | - |
Sphingobium chlorophenolicum | 2,3,5,6-tetrachlorohydroquinone + NADP+ + chloride + H2O | - |
? | |
| 1.14.13.50 | pentachlorophenol + NADPH + H+ + O2 | - |
Mycolicibacterium chlorophenolicum | 2,3,5,6-tetrachlorohydroquinone + NADP+ + chloride + H2O | - |
? | |
| 1.14.13.50 | pentachlorophenol + NADPH + H+ + O2 | initial enzyme in the PCP catabolic pathway of numerous sphingomonads, PCP-4-monooxygenase (PcpB), catalyzes the parahydroxylation of PCP to tetrachlorohydroquinone, pentachlorophenol degradation pathway, overview | Sphingomonas sp. | 2,3,5,6-tetrachlorohydroquinone + NADP+ + chloride + H2O | - |
? | |
| 1.14.13.50 | pentachlorophenol + NADPH + H+ + O2 | initial enzyme in the PCP catabolic pathway of numerous sphingomonads, PCP-4-monooxygenase (PcpB), catalyzes the parahydroxylation of PCP to tetrachlorohydroquinone, pentachlorophenol degradation pathway, overview | Sphingobium chlorophenolicum | 2,3,5,6-tetrachlorohydroquinone + NADP+ + chloride + H2O | - |
? | |
| 1.14.13.50 | pentachlorophenol + NADPH + H+ + O2 | initial enzyme in the PCP catabolic pathway of numerous sphingomonads, PCP-4-monooxygenase (PcpB), catalyzes the parahydroxylation of PCP to tetrachlorohydroquinone, pentachlorophenol degradation pathway, overview | Mycolicibacterium chlorophenolicum | 2,3,5,6-tetrachlorohydroquinone + NADP+ + chloride + H2O | - |
? | |
| 1.14.13.50 | tribromophenol + NADPH + O2 | - |
Sphingobium chlorophenolicum | ? | - |
? | |
| 1.14.13.50 | triiodophenol + NADPH + O2 | - |
Sphingobium chlorophenolicum | ? | - |
? | |
| 1.14.13.50 | Tween 20 + NADPH + O2 | - |
Sphingobium chlorophenolicum | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.13.50 | PCP-4-monooxygenase | - |
Sphingomonas sp. |
| 1.14.13.50 | PCP-4-monooxygenase | - |
Sphingobium chlorophenolicum |
| 1.14.13.50 | PCP-4-monooxygenase | - |
Mycolicibacterium chlorophenolicum |
| 1.14.13.50 | PcpB | - |
Sphingomonas sp. |
| 1.14.13.50 | PcpB | - |
Sphingobium chlorophenolicum |
| 1.14.13.50 | PcpB | - |
Mycolicibacterium chlorophenolicum |
| 1.14.13.50 | pentachlorophenol-4-monooxygenase | - |
Sphingomonas sp. |
| 1.14.13.50 | pentachlorophenol-4-monooxygenase | - |
Sphingobium chlorophenolicum |
| 1.14.13.50 | pentachlorophenol-4-monooxygenase | - |
Mycolicibacterium chlorophenolicum |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.13.50 | NADPH | - |
Sphingomonas sp. | |
| 1.14.13.50 | NADPH | - |
Sphingobium chlorophenolicum | |
| 1.14.13.50 | NADPH | - |
Mycolicibacterium chlorophenolicum | |
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