Any feedback?
Literature summary extracted from
- Na(+)-translocating NADH:quinone oxidoreductase: progress achieved and prospects of investigations (2005), Biochemistry (Moscow), 70, 143-149.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.2.1.1 | 2-heptyl-4-hydroxyquinoline N-oxide | - |
Haemophilus influenzae |  |
| 7.2.1.1 | 2-heptyl-4-hydroxyquinoline N-oxide | - |
Klebsiella pneumoniae | |
| 7.2.1.1 | 2-heptyl-4-hydroxyquinoline N-oxide | - |
Neisseria gonorrhoeae | |
| 7.2.1.1 | 2-heptyl-4-hydroxyquinoline N-oxide | - |
Neisseria meningitidis | |
| 7.2.1.1 | 2-heptyl-4-hydroxyquinoline N-oxide | - |
Porphyromonas gingivalis | |
| 7.2.1.1 | 2-heptyl-4-hydroxyquinoline N-oxide | - |
Pseudomonas aeruginosa | |
| 7.2.1.1 | 2-heptyl-4-hydroxyquinoline N-oxide | - |
Salinivibrio costicola | |
| 7.2.1.1 | 2-heptyl-4-hydroxyquinoline N-oxide | - |
Shewanella putrefaciens | |
| 7.2.1.1 | 2-heptyl-4-hydroxyquinoline N-oxide | - |
Vibrio alginolyticus | |
| 7.2.1.1 | 2-heptyl-4-hydroxyquinoline N-oxide | - |
Vibrio harveyi | |
| 7.2.1.1 | 2-heptyl-4-hydroxyquinoline N-oxide | - |
Yersinia pestis | |
| 7.2.1.1 | Ag+ | - |
Salinivibrio costicola | |
| 7.2.1.1 | Ag+ | - |
Vibrio alginolyticus | |
| 7.2.1.1 | Ag2+ | - |
Vibrio harveyi | |
| 7.2.1.1 | Cd2+ | - |
Salinivibrio costicola | |
| 7.2.1.1 | Cd2+ | - |
Vibrio alginolyticus | |
| 7.2.1.1 | Cd2+ | - |
Vibrio harveyi | |
| 7.2.1.1 | Cu2+ | - |
Salinivibrio costicola | |
| 7.2.1.1 | Cu2+ | - |
Vibrio alginolyticus | |
| 7.2.1.1 | Cu2+ | - |
Vibrio harveyi | |
| 7.2.1.1 | korormicin | - |
Haemophilus influenzae | |
| 7.2.1.1 | korormicin | - |
Klebsiella pneumoniae | |
| 7.2.1.1 | korormicin | - |
Neisseria gonorrhoeae | |
| 7.2.1.1 | korormicin | - |
Neisseria meningitidis | |
| 7.2.1.1 | korormicin | - |
Porphyromonas gingivalis | |
| 7.2.1.1 | korormicin | - |
Pseudomonas aeruginosa | |
| 7.2.1.1 | korormicin | - |
Salinivibrio costicola | |
| 7.2.1.1 | korormicin | - |
Shewanella putrefaciens | |
| 7.2.1.1 | korormicin | - |
Vibrio alginolyticus | |
| 7.2.1.1 | korormicin | - |
Vibrio harveyi | |
| 7.2.1.1 | korormicin | - |
Yersinia pestis | |
| 7.2.1.1 | Zn2+ | - |
Salinivibrio costicola | |
| 7.2.1.1 | Zn2+ | - |
Vibrio alginolyticus | |
| 7.2.1.1 | Zn2+ | - |
Vibrio harveyi | |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.2.1.1 | Na+ | stimulates enzyme activity | Vibrio harveyi | |
| 7.2.1.1 | Na+ | stimulates enzyme activity | Salinivibrio costicola | |
| 7.2.1.1 | Na+ | stimulates enzyme activity | Vibrio alginolyticus | |
| 7.2.1.1 | [2Fe-2S] | noncovalently bound to subunit NqrF | Haemophilus influenzae | |
| 7.2.1.1 | [2Fe-2S] | noncovalently bound to subunit NqrF | Vibrio harveyi | |
| 7.2.1.1 | [2Fe-2S] | noncovalently bound to subunit NqrF | Pseudomonas aeruginosa | |
| 7.2.1.1 | [2Fe-2S] | noncovalently bound to subunit NqrF | Neisseria gonorrhoeae | |
| 7.2.1.1 | [2Fe-2S] | noncovalently bound to subunit NqrF | Neisseria meningitidis | |
| 7.2.1.1 | [2Fe-2S] | noncovalently bound to subunit NqrF | Klebsiella pneumoniae | |
| 7.2.1.1 | [2Fe-2S] | noncovalently bound to subunit NqrF | Yersinia pestis | |
| 7.2.1.1 | [2Fe-2S] | noncovalently bound to subunit NqrF | Salinivibrio costicola | |
| 7.2.1.1 | [2Fe-2S] | noncovalently bound to subunit NqrF | Porphyromonas gingivalis | |
| 7.2.1.1 | [2Fe-2S] | noncovalently bound to subunit NqrF | Vibrio alginolyticus | |
| 7.2.1.1 | [2Fe-2S] | noncovalently bound to subunit NqrF | Shewanella putrefaciens | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 7.2.1.1 | 21500 | - |
subunit NqrE | Vibrio harveyi |
| 7.2.1.1 | 22700 | - |
subunit NqrD | Vibrio harveyi |
| 7.2.1.1 | 27500 | - |
subunit NqrC | Vibrio harveyi |
| 7.2.1.1 | 45200 | - |
subunit NqrF | Vibrio harveyi |
| 7.2.1.1 | 45400 | - |
subunit NqrB | Vibrio harveyi |
| 7.2.1.1 | 48400 | - |
subunit NqrA | Vibrio harveyi |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 7.2.1.1 | Haemophilus influenzae | - |
- |
- |
| 7.2.1.1 | Klebsiella pneumoniae | - |
- |
- |
| 7.2.1.1 | Neisseria gonorrhoeae | - |
- |
- |
| 7.2.1.1 | Neisseria meningitidis | - |
- |
- |
| 7.2.1.1 | Porphyromonas gingivalis | - |
- |
- |
| 7.2.1.1 | Pseudomonas aeruginosa | - |
- |
- |
| 7.2.1.1 | Salinivibrio costicola | - |
- |
- |
| 7.2.1.1 | Shewanella putrefaciens | - |
- |
- |
| 7.2.1.1 | Vibrio alginolyticus | - |
- |
- |
| 7.2.1.1 | Vibrio harveyi | - |
- |
- |
| 7.2.1.1 | Yersinia pestis | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 7.2.1.1 | NADH + ubiquinone + Na+/in | - |
Haemophilus influenzae | NAD+ + ubiquinol + Na+/out | - |
? | |
| 7.2.1.1 | NADH + ubiquinone + Na+/in | - |
Vibrio harveyi | NAD+ + ubiquinol + Na+/out | - |
? | |
| 7.2.1.1 | NADH + ubiquinone + Na+/in | - |
Pseudomonas aeruginosa | NAD+ + ubiquinol + Na+/out | - |
? | |
| 7.2.1.1 | NADH + ubiquinone + Na+/in | - |
Neisseria gonorrhoeae | NAD+ + ubiquinol + Na+/out | - |
? | |
| 7.2.1.1 | NADH + ubiquinone + Na+/in | - |
Neisseria meningitidis | NAD+ + ubiquinol + Na+/out | - |
? | |
| 7.2.1.1 | NADH + ubiquinone + Na+/in | - |
Klebsiella pneumoniae | NAD+ + ubiquinol + Na+/out | - |
? | |
| 7.2.1.1 | NADH + ubiquinone + Na+/in | - |
Yersinia pestis | NAD+ + ubiquinol + Na+/out | - |
? | |
| 7.2.1.1 | NADH + ubiquinone + Na+/in | - |
Salinivibrio costicola | NAD+ + ubiquinol + Na+/out | - |
? | |
| 7.2.1.1 | NADH + ubiquinone + Na+/in | - |
Porphyromonas gingivalis | NAD+ + ubiquinol + Na+/out | - |
? | |
| 7.2.1.1 | NADH + ubiquinone + Na+/in | - |
Vibrio alginolyticus | NAD+ + ubiquinol + Na+/out | - |
? | |
| 7.2.1.1 | NADH + ubiquinone + Na+/in | - |
Shewanella putrefaciens | NAD+ + ubiquinol + Na+/out | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 7.2.1.1 | hexamer | 1 * 48400, 1 * 45400, 1 * 27500, 1 * 22700, 1 * 21500, 1 * 45200 | Vibrio harveyi |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 7.2.1.1 | Na(+)-translocating NADH:quinone oxidoreductase | - |
Haemophilus influenzae |
| 7.2.1.1 | Na(+)-translocating NADH:quinone oxidoreductase | - |
Vibrio harveyi |
| 7.2.1.1 | Na(+)-translocating NADH:quinone oxidoreductase | - |
Pseudomonas aeruginosa |
| 7.2.1.1 | Na(+)-translocating NADH:quinone oxidoreductase | - |
Neisseria gonorrhoeae |
| 7.2.1.1 | Na(+)-translocating NADH:quinone oxidoreductase | - |
Neisseria meningitidis |
| 7.2.1.1 | Na(+)-translocating NADH:quinone oxidoreductase | - |
Klebsiella pneumoniae |
| 7.2.1.1 | Na(+)-translocating NADH:quinone oxidoreductase | - |
Yersinia pestis |
| 7.2.1.1 | Na(+)-translocating NADH:quinone oxidoreductase | - |
Salinivibrio costicola |
| 7.2.1.1 | Na(+)-translocating NADH:quinone oxidoreductase | - |
Porphyromonas gingivalis |
| 7.2.1.1 | Na(+)-translocating NADH:quinone oxidoreductase | - |
Vibrio alginolyticus |
| 7.2.1.1 | Na(+)-translocating NADH:quinone oxidoreductase | - |
Shewanella putrefaciens |
| 7.2.1.1 | Na+-NQR | - |
Haemophilus influenzae |
| 7.2.1.1 | Na+-NQR | - |
Vibrio harveyi |
| 7.2.1.1 | Na+-NQR | - |
Pseudomonas aeruginosa |
| 7.2.1.1 | Na+-NQR | - |
Neisseria gonorrhoeae |
| 7.2.1.1 | Na+-NQR | - |
Neisseria meningitidis |
| 7.2.1.1 | Na+-NQR | - |
Klebsiella pneumoniae |
| 7.2.1.1 | Na+-NQR | - |
Yersinia pestis |
| 7.2.1.1 | Na+-NQR | - |
Salinivibrio costicola |
| 7.2.1.1 | Na+-NQR | - |
Porphyromonas gingivalis |
| 7.2.1.1 | Na+-NQR | - |
Vibrio alginolyticus |
| 7.2.1.1 | Na+-NQR | - |
Shewanella putrefaciens |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.2.1.1 | FAD | noncovalently bound to subunit NqrF | Haemophilus influenzae | |
| 7.2.1.1 | FAD | noncovalently bound to subunit NqrF | Vibrio harveyi | |
| 7.2.1.1 | FAD | noncovalently bound to subunit NqrF | Pseudomonas aeruginosa | |
| 7.2.1.1 | FAD | noncovalently bound to subunit NqrF | Neisseria gonorrhoeae | |
| 7.2.1.1 | FAD | noncovalently bound to subunit NqrF | Neisseria meningitidis | |
| 7.2.1.1 | FAD | noncovalently bound to subunit NqrF | Klebsiella pneumoniae | |
| 7.2.1.1 | FAD | noncovalently bound to subunit NqrF | Yersinia pestis | |
| 7.2.1.1 | FAD | noncovalently bound to subunit NqrF | Salinivibrio costicola | |
| 7.2.1.1 | FAD | noncovalently bound to subunit NqrF | Porphyromonas gingivalis | |
| 7.2.1.1 | FAD | noncovalently bound to subunit NqrF | Vibrio alginolyticus | |
| 7.2.1.1 | FAD | noncovalently bound to subunit NqrF | Shewanella putrefaciens | |
| 7.2.1.1 | FMN | covalently bound to subunits NqrB and NqrC | Haemophilus influenzae | |
| 7.2.1.1 | FMN | covalently bound to subunits NqrB and NqrC | Vibrio harveyi | |
| 7.2.1.1 | FMN | covalently bound to subunits NqrB and NqrC | Pseudomonas aeruginosa | |
| 7.2.1.1 | FMN | covalently bound to subunits NqrB and NqrC | Neisseria gonorrhoeae | |
| 7.2.1.1 | FMN | covalently bound to subunits NqrB and NqrC | Neisseria meningitidis | |
| 7.2.1.1 | FMN | covalently bound to subunits NqrB and NqrC | Klebsiella pneumoniae | |
| 7.2.1.1 | FMN | covalently bound to subunits NqrB and NqrC | Yersinia pestis | |
| 7.2.1.1 | FMN | covalently bound to subunits NqrB and NqrC | Salinivibrio costicola | |
| 7.2.1.1 | FMN | covalently bound to subunits NqrB and NqrC | Porphyromonas gingivalis | |
| 7.2.1.1 | FMN | covalently bound to subunits NqrB and NqrC | Vibrio alginolyticus | |
| 7.2.1.1 | FMN | covalently bound to subunits NqrB and NqrC | Shewanella putrefaciens | |
| 7.2.1.1 | NADH | - |
Vibrio harveyi | |
| 7.2.1.1 | NADH | - |
Vibrio alginolyticus | |
| 7.2.1.1 | NADH | specific for NADH | Haemophilus influenzae | |
| 7.2.1.1 | NADH | specific for NADH | Pseudomonas aeruginosa | |
| 7.2.1.1 | NADH | specific for NADH | Neisseria gonorrhoeae | |
| 7.2.1.1 | NADH | specific for NADH | Neisseria meningitidis | |
| 7.2.1.1 | NADH | specific for NADH | Klebsiella pneumoniae | |
| 7.2.1.1 | NADH | specific for NADH | Yersinia pestis | |
| 7.2.1.1 | NADH | specific for NADH | Salinivibrio costicola | |
| 7.2.1.1 | NADH | specific for NADH | Porphyromonas gingivalis | |
| 7.2.1.1 | NADH | specific for NADH | Shewanella putrefaciens | |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 7.2.1.1 | 0.0000001 | - |
korormicin | - |
Vibrio harveyi | |
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