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Literature summary extracted from

  • Strumilo, S.
    Short-term regulation of the alpha-ketoglutarate dehydrogenase complex by energy-linked and some other effectors (2005), Biochemistry, 70, 726-729.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.2.1.105 ADP
-
 Escherichia coli
1.2.1.105 ADP
-
 Homo sapiens
1.2.1.105 ADP
-
 Rattus norvegicus
1.2.1.105 ADP
-
 Sus scrofa
1.2.1.105 ADP
-
 Bos taurus
1.2.1.105 ADP
-
 Solanum tuberosum
1.2.1.105 ADP
-
 Columba livia
1.2.1.105 inorganic phosphate
-
 Solanum tuberosum
1.2.1.105 phosphate
-
 Escherichia coli
1.2.1.105 phosphate
-
 Sus scrofa
1.2.1.105 phosphate
-
 Bison bison
1.2.1.105 thiamine diphosphate KGDHC is saturated with endogenous tightly bound thiamine diphosphate, but the addition of exogenous thiamine diphosphate to the reaction medium leads to a marked increase in KGDHC affinity to 2-oxoglutarate Bison bison

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.105 ATP inhibits KGDHC in the kidney, in adrenals the effect is rather weak Bos taurus
1.2.1.105 ATP weakly inhibits in breast muscles Columba livia
1.2.1.105 ATP inhibits KGDHC in the heart Sus scrofa
1.2.1.105 NADH allosteric inhibition Bos taurus
1.2.1.105 NADH allosteric inhibition Columba livia

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.2.1.105 mitochondrion
-
 Rattus norvegicus 5739
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.2.1.105 Ca2+
-
 Rattus norvegicus
1.2.1.105 Ca2+
-
 Sus scrofa
1.2.1.105 Ca2+
-
 Bos taurus
1.2.1.105 Mn2+
-
 Bison bison
1.2.1.105 additional information Ca2+ is no activator Escherichia coli
1.2.1.105 additional information Ca2+ is no activator Solanum tuberosum

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.105 Bison bison
-
-
-
1.2.1.105 Bos taurus
-
-
-
1.2.1.105 Columba livia
-
-
-
1.2.1.105 Escherichia coli
-
-
-
1.2.1.105 Homo sapiens
-
-
-
1.2.1.105 Rattus norvegicus
-
-
-
1.2.1.105 Solanum tuberosum
-
-
-
1.2.1.105 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.105 breast
-
 Columba livia
-
1.2.1.105 heart
-
 Homo sapiens
-
1.2.1.105 heart
-
 Rattus norvegicus
-
1.2.1.105 heart
-
 Sus scrofa
-
1.2.1.105 heart
-
 Bison bison
-
1.2.1.105 kidney
-
 Bos taurus
-
1.2.1.105 additional information adrenals Bos taurus
-
1.2.1.105 muscle
-
 Columba livia
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.105 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine
-
 Sus scrofa [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
-
 ?
1.2.1.105 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine
-
 Columba livia [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
-
 ?
1.2.1.105 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine
-
 Bison bison [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.2.1.105 alpha-ketoglutarate dehydrogenase complex
-
 Escherichia coli
1.2.1.105 alpha-ketoglutarate dehydrogenase complex
-
 Homo sapiens
1.2.1.105 alpha-ketoglutarate dehydrogenase complex
-
 Rattus norvegicus
1.2.1.105 alpha-ketoglutarate dehydrogenase complex
-
 Sus scrofa
1.2.1.105 alpha-ketoglutarate dehydrogenase complex
-
 Bos taurus
1.2.1.105 alpha-ketoglutarate dehydrogenase complex
-
 Solanum tuberosum
1.2.1.105 alpha-ketoglutarate dehydrogenase complex
-
 Columba livia
1.2.1.105 alpha-ketoglutarate dehydrogenase complex
-
 Bison bison
1.2.1.105 KGDHC
-
 Escherichia coli
1.2.1.105 KGDHC
-
 Homo sapiens
1.2.1.105 KGDHC
-
 Rattus norvegicus
1.2.1.105 KGDHC
-
 Sus scrofa
1.2.1.105 KGDHC
-
 Bos taurus
1.2.1.105 KGDHC
-
 Solanum tuberosum
1.2.1.105 KGDHC
-
 Columba livia
1.2.1.105 KGDHC
-
 Bison bison