Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Sorci, L.; Cimadamore, F.; Scotti, S.; Petrelli, R.; Cappellacci, L.; Franchetti, P.; Orsomando, G.; Magni, G.
    Initial-rate kinetics of human NMN-adenylyltransferases: substrate and metal ion specificity, inhibition by products and multisubstrate analogues, and isozyme contributions to NAD+ biosynthesis (2007), Biochemistry, 46, 4912-4922.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.7.1 His-tagged isozymes NMNAT1, NMNAT2, and NMNAT3, expression in Escherichia coli strain BL21(DE3) Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.1 diphosphate product inhibition, noncompetitive for isozyme NMNAT1, and mixed-type for isozymes NMNAT2 and NMNAT3, both versus ATP and NMN; product inhibition, noncompetitive for isozyme NMNAT1, and mixed-type for isozymes NMNAT2 and NMNAT3, both versus ATP and NMN; product inhibition, noncompetitive for isozyme NMNAT1, and mixed-type for isozymes NMNAT2 and NMNAT3, both versus ATP and NMN Homo sapiens
2.7.7.1 gallotannin polyphenolic plant metabolite that inhibits all three human NMNATs; polyphenolic plant metabolite that inhibits all three human NMNATs; polyphenolic plant metabolite that inhibits all three human NMNATs Homo sapiens
2.7.7.1 NaAD+ i.e. nicotinic acid adenine dinucleotide, product inhibition, competitive for isozyme NMNAT3, and mixed-type for isozymes NMNAT1 and NMNAT2 NMN, and vice versa against ATP; i.e. nicotinic acid adenine dinucleotide, product inhibition, competitive for isozyme NMNAT3, and mixed-type for isozymes NMNAT1 and NMNAT2 NMN, and vice versa against ATP; i.e. nicotinic acid adenine dinucleotide, product inhibition, competitive for isozyme NMNAT3, and mixed-type for isozymes NMNAT1 and NMNAT2 NMN, and vice versa against ATP Homo sapiens
2.7.7.1 NAD+ product inhibition, competitive for isozyme NMNAT3, and mixed-type for isozymes NMNAT1 and NMNAT2 NMN, and vice versa against ATP; product inhibition, competitive for isozyme NMNAT3, and mixed-type for isozymes NMNAT1 and NMNAT2 NMN, and vice versa against ATP; product inhibition, competitive for isozyme NMNAT3, and mixed-type for isozymes NMNAT1 and NMNAT2 NMN, and vice versa against ATP Homo sapiens
2.7.7.1 P1-(adenosine-5')-P3-(nicotinamide-riboside-5')-triphosphate
-
 Homo sapiens
2.7.7.1 P1-(adenosine-5')-P4-(nicotinamide-riboside-5')-tetraphosphate
-
 Homo sapiens
2.7.7.1 P1-(adenosine-5')-P4-(nicotinic-acid-riboside-5')-tetraphosphate
-
 Homo sapiens
2.7.7.1 P1-(nicotinamide-riboside-5')-P3-(adenosine-5')-triphosphate i.e. Np3AD; i.e. Np3AD; i.e. Np3AD Homo sapiens
2.7.7.1 P1-(nicotinamide-riboside-5')-P4-(adenosine-5')-tetraphosphate i.e. Np4AD; i.e. Np4AD; i.e. Np4AD Homo sapiens
2.7.7.1 P1-(nicotinate-riboside-5')-P4-(adenosine-5')-tetraphosphate i.e. Nap4AD; i.e. Nap4AD; i.e. Nap4AD Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.7.1 additional information
-
 additional information initial and steady-state kinetics, kinetic mechanisms of the three NMNAT isozymes, overview Homo sapiens
2.7.7.1 0.0145
-
 nicotinic acid mononucleotide NMNAT2 Homo sapiens
2.7.7.1 0.0145
-
 nicotinic acid mononucleotide pH 7.5, 37°C, isozyme NMNAT2 Homo sapiens
2.7.7.1 0.0213
-
 NMN NMNAT2 Homo sapiens
2.7.7.1 0.0213
-
 NMN pH 7.5, 37°C, isozyme NMNAT2 Homo sapiens
2.7.7.1 0.0223
-
 NMN NMNAT1 Homo sapiens
2.7.7.1 0.0223
-
 NMN pH 7.5, 37°C, isozyme NMNAT1 Homo sapiens
2.7.7.1 0.0421
-
 ATP NMNAT3 Homo sapiens
2.7.7.1 0.0421
-
 ATP pH 7.5, 37°C, isozyme NMNAT3 Homo sapiens
2.7.7.1 0.0585
-
 ATP NMNAT1 Homo sapiens
2.7.7.1 0.0585
-
 ATP pH 7.5, 37°C, isozyme NMNAT1 Homo sapiens
2.7.7.1 0.0662
-
 NMN NMNAT3 Homo sapiens
2.7.7.1 0.0662
-
 NMN pH 7.5, 37°C, isozyme NMNAT3 Homo sapiens
2.7.7.1 0.0677
-
 nicotinic acid mononucleotide NMNAT1 Homo sapiens
2.7.7.1 0.0677
-
 nicotinic acid mononucleotide pH 7.5, 37°C, isozyme NMNAT1 Homo sapiens
2.7.7.1 0.0889
-
 ATP NMNAT2 Homo sapiens
2.7.7.1 0.0889
-
 ATP pH 7.5, 37°C, isozyme NMNAT2 Homo sapiens
2.7.7.1 0.111
-
 nicotinic acid mononucleotide NMNAT3 Homo sapiens
2.7.7.1 0.111
-
 nicotinic acid mononucleotide pH 7.5, 37°C, isozyme NMNAT3 Homo sapiens
2.7.7.1 0.13
-
 NMNH NMNAT3 Homo sapiens
2.7.7.1 0.13
-
 NMNH pH 7.5, 37°C, isozyme NMNAT3 Homo sapiens
2.7.7.1 0.276
-
 GTP NMNAT3 Homo sapiens
2.7.7.1 0.294
-
 NMNH NMNAT1 Homo sapiens
2.7.7.1 0.294
-
 NMNH pH 7.5, 37°C, isozyme NMNAT1 Homo sapiens
2.7.7.1 0.304
-
 NMNH NMNAT2 Homo sapiens
2.7.7.1 0.304
-
 NMNH pH 7.5, 37°C, isozyme NMNAT2 Homo sapiens
2.7.7.1 0.35
-
 ITP NMNAT3 Homo sapiens
2.7.7.1 0.37
-
 tiazofurin monophosphate NMNAT1 Homo sapiens
2.7.7.1 0.37
-
 tiazofurin riboside 5'-monophosphate pH 7.5, 37°C, isozyme NMNAT1 Homo sapiens
2.7.7.1 2.01
-
 tiazofurin monophosphate NMNAT3 Homo sapiens
2.7.7.1 2.1
-
 tiazofurin riboside 5'-monophosphate pH 7.5, 37°C, isozyme NMNAT3 Homo sapiens
2.7.7.1 100
-
 tiazofurin monophosphate NMNAT2 Homo sapiens
2.7.7.1 100
-
 tiazofurin riboside 5'-monophosphate above, pH 7.5, 37°C, isozyme NMNAT2 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.7.1 Golgi apparatus NMNAT2 Homo sapiens 5794
-
2.7.7.1 Golgi apparatus isozyme NMNAT2 Homo sapiens 5794
-
2.7.7.1 mitochondrion NMNAT3 Homo sapiens 5739
-
2.7.7.1 mitochondrion isozyme NMNAT3 Homo sapiens 5739
-
2.7.7.1 nucleus Nmnat1 Homo sapiens 5634
-
2.7.7.1 nucleus isozyme NMNAT1 Homo sapiens 5634
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.7.1 Mg2+ most effective ion with NMNAT2 and NMNAT3 Homo sapiens
2.7.7.1 Mg2+ most effective ion with isozymes NMNAT2 and NMNAT3 Homo sapiens
2.7.7.1 additional information NMNAT activity requires the presence of divalent cations. Homo sapiens
2.7.7.1 Zn2+ most effective ion with NMNAT1 Homo sapiens
2.7.7.1 Zn2+ most effective ion with isozyme NMNAT1 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.7.1 32700
-
 for NMNAT3, SDS-PAGE Homo sapiens
2.7.7.1 32700
-
 x * 36000, isozyme NMNAT1, SDS-PAGE, x * 37000, isozyme NMNAT2, SDS-PAGE, x * 32700, isozyme NMNAT3, SDS-PAGE Homo sapiens
2.7.7.1 36000
-
 for NMNAT1, SDS-PAGE Homo sapiens
2.7.7.1 36000
-
 x * 36000, isozyme NMNAT1, SDS-PAGE, x * 37000, isozyme NMNAT2, SDS-PAGE, x * 32700, isozyme NMNAT3, SDS-PAGE Homo sapiens
2.7.7.1 37000
-
 for NMNAT2, SDS-PAGE Homo sapiens
2.7.7.1 37000
-
 x * 36000, isozyme NMNAT1, SDS-PAGE, x * 37000, isozyme NMNAT2, SDS-PAGE, x * 32700, isozyme NMNAT3, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.1 ATP + NMN Homo sapiens
-
 diphosphate + NAD+
-
 ?
2.7.7.1 GTP + nicotinamide ribonucleotide Homo sapiens only isoenzyme NMNAT3 nicotineamide guanine dinucleotide + diphosphate
-
 ?
2.7.7.1 ITP + nicotinamide ribonucleotide Homo sapiens only isoenzyme NMNAT3 nicotinamide hypoxanthine dinucleotide + diphosphate
-
 ?
2.7.7.1 NMN + ATP Homo sapiens
-
 NAD+ + diphosphate
-
 ?
2.7.7.1 tiazofurin monophosphate + ATP Homo sapiens
-
 tiazofurin adenine dinucleotide + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.1 Homo sapiens Q96T66
-
-
2.7.7.1 Homo sapiens Q96T66 isozyme NMNAT3; isozyme NMNAT3
-
2.7.7.1 Homo sapiens Q9BZQ4
-
-
2.7.7.1 Homo sapiens Q9BZQ4 isozyme NMNAT2; isozyme NMNAT2
-
2.7.7.1 Homo sapiens Q9HAN9
-
-
2.7.7.1 Homo sapiens Q9HAN9 isozyme NMNAT1; isozyme NMNAT1
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.7.1 recombinant His-tagged isozymes NMNAT1, NMNAT2, and NMNAT3 from Escherichia coli strain BL21(DE3) by nickel or TALON affinity chromatography Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.7.1 brain
-
 Homo sapiens
-
2.7.7.1 brain predominance of isozyme NMNAT1 Homo sapiens
-
2.7.7.1 Hep-G2 cell hepatocellular carcinoma cell line, predominance of isozyme NMNAT1, isozyme NMNAT3 is only present in liver and HepG2 cells Homo sapiens
-
2.7.7.1 liver
-
 Homo sapiens
-
2.7.7.1 liver predominance of isozyme NMNAT1, isozyme NMNAT3 is only present in liver and HepG2 cells Homo sapiens
-
2.7.7.1 SK-HEP-1 cell hepatocellular carcinoma cell line, isozyme NMNAT2 is found exclusively in SK-HEP1 cells Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.1 ATP + nicotinate D-ribonucleotide
-
 Homo sapiens diphosphate + nicotinate adenine dinucleotide i.e. nicotinic acid adenine dinucleotide ?
2.7.7.1 ATP + NMN
-
 Homo sapiens diphosphate + NAD+
-
 ?
2.7.7.1 ATP + NMN ATP binds before NMN with nuclear isozyme NMNAT1 and Golgi apparatus NMNAT2, but the opposite order is observed with the mitochondrial isozyme NMNAT3 Homo sapiens diphosphate + NAD+
-
 ?
2.7.7.1 ATP + NMNH
-
 Homo sapiens diphosphate + NADH
-
 ?
2.7.7.1 ATP + tiazofurin 5'-monophosphate i.e. TrMP, substrate od isozymes NMNAT1 and NMNAT3, but not of isozyme NMNAT2 Homo sapiens ?
-
 ?
2.7.7.1 ATP + tiazofurin monophosphate i.e. TrMP, substrate od isozymes NMNAT1 and NMNAT3, but not of isozyme NMNAT2 Homo sapiens ?
-
 ?
2.7.7.1 GTP + nicotinamide ribonucleotide only isoenzyme NMNAT3 Homo sapiens nicotineamide guanine dinucleotide + diphosphate
-
 ?
2.7.7.1 GTP + NMN substrates of isozyme NMNAT3 Homo sapiens diphosphate + NGD+ i.e. nicotinamide guanosine dinucleotide ?
2.7.7.1 ITP + nicotinamide ribonucleotide only isoenzyme NMNAT3 Homo sapiens nicotinamide hypoxanthine dinucleotide + diphosphate
-
 ?
2.7.7.1 ITP + NMN substrates of isozyme NMNAT3 Homo sapiens diphosphate + inosine nicotinamide dinucleotide i.e. nicotinamide hypoxanthine dinucleotide ?
2.7.7.1 nicotinic acid mononucleotide + ATP
-
 Homo sapiens nicotinic acid adenine dinucleotide + diphosphate
-
 ?
2.7.7.1 NMN + ATP
-
 Homo sapiens NAD+ + diphosphate
-
 ?
2.7.7.1 tiazofurin monophosphate + ATP
-
 Homo sapiens tiazofurin adenine dinucleotide + diphosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.7.1 ? x * 36000, isozyme NMNAT1, SDS-PAGE, x * 37000, isozyme NMNAT2, SDS-PAGE, x * 32700, isozyme NMNAT3, SDS-PAGE Homo sapiens
2.7.7.1 hexamer NMNAT1 Homo sapiens
2.7.7.1 monomer NMNAT2 Homo sapiens
2.7.7.1 tetramer NMNAT3 Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.7.7.1 human nicotinamide mononucleotide adenylyl-transferase
-
 Homo sapiens
2.7.7.1 nicotinamide mononucleotide adenylyl-transferase
-
 Homo sapiens
2.7.7.1 NMN-adenylyltransferase
-
 Homo sapiens
2.7.7.1 NMNAT
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.7.1 37
-
 assay at Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.7.7.1 0.42
-
 tiazofurin riboside 5'-monophosphate pH 7.5, 37°C, isozyme NMNAT3 Homo sapiens
2.7.7.1 0.55
-
 tiazofurin riboside 5'-monophosphate pH 7.5, 37°C, isozyme NMNAT2 Homo sapiens
2.7.7.1 2.5
-
 ATP pH 7.5, 37°C, isozyme NMNAT3 Homo sapiens
2.7.7.1 2.5
-
 NMN pH 7.5, 37°C, isozyme NMNAT3 Homo sapiens
2.7.7.1 3.3
-
 NMNH pH 7.5, 37°C, isozyme NMNAT2 Homo sapiens
2.7.7.1 3.8
-
 nicotinic acid mononucleotide pH 7.5, 37°C, isozyme NMNAT3 Homo sapiens
2.7.7.1 6.9
-
 nicotinic acid mononucleotide pH 7.5, 37°C, isozyme NMNAT2 Homo sapiens
2.7.7.1 7.2
-
 NMNH pH 7.5, 37°C, isozyme NMNAT3 Homo sapiens
2.7.7.1 8.8
-
 ATP pH 7.5, 37°C, isozyme NMNAT2 Homo sapiens
2.7.7.1 8.8
-
 NMN pH 7.5, 37°C, isozyme NMNAT2 Homo sapiens
2.7.7.1 14.9
-
 tiazofurin riboside 5'-monophosphate pH 7.5, 37°C, isozyme NMNAT1 Homo sapiens
2.7.7.1 18.6
-
 NMNH pH 7.5, 37°C, isozyme NMNAT1 Homo sapiens
2.7.7.1 42.9
-
 nicotinic acid mononucleotide pH 7.5, 37°C, isozyme NMNAT1 Homo sapiens
2.7.7.1 53.8
-
 NMN pH 7.5, 37°C, isozyme NMNAT1 Homo sapiens
2.7.7.1 53.9
-
 ATP pH 7.5, 37°C, isozyme NMNAT1 Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.7.1 7.5
-
 assay at Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.7.1 0.0217
-
 P1-(adenosine-5')-P4-(nicotinic-acid-riboside-5')-tetraphosphate substrate: NMN, isoenzyme: NMNAT3 Homo sapiens
2.7.7.1 0.0217
-
 P1-(nicotinate-riboside-5')-P4-(adenosine-5')-tetraphosphate pH 7.5, 37°C, isozyme NMNAT3, versus substrate NaMN Homo sapiens
2.7.7.1 0.023
-
 NaAD+ product inhibition of NMNAT2, substrate ATP Homo sapiens
2.7.7.1 0.0242
-
 P1-(adenosine-5')-P4-(nicotinamide-riboside-5')-tetraphosphate substrate: ATP, isoenzyme: NMNAT2 Homo sapiens
2.7.7.1 0.0242
-
 P1-(nicotinamide-riboside-5')-P4-(adenosine-5')-tetraphosphate pH 7.5, 37°C, isozyme NMNAT2, versus substrate ATP Homo sapiens
2.7.7.1 0.0258
-
 P1-(adenosine-5')-P4-(nicotinamide-riboside-5')-tetraphosphate substrate: NMN, isoenzyme: NMNAT2 Homo sapiens
2.7.7.1 0.0258
-
 P1-(nicotinamide-riboside-5')-P4-(adenosine-5')-tetraphosphate pH 7.5, 37°C, isozyme NMNAT2, versus substrate NMN Homo sapiens
2.7.7.1 0.0298
-
 P1-(adenosine-5')-P4-(nicotinamide-riboside-5')-tetraphosphate substrate: ATP, isoenzyme: NMNAT3 Homo sapiens
2.7.7.1 0.0298
-
 P1-(nicotinamide-riboside-5')-P4-(adenosine-5')-tetraphosphate pH 7.5, 37°C, isozyme NMNAT3, versus substrate ATP Homo sapiens
2.7.7.1 0.0311
-
 P1-(adenosine-5')-P4-(nicotinamide-riboside-5')-tetraphosphate substrate: NMN, isoenzyme: NMNAT1 Homo sapiens
2.7.7.1 0.0311
-
 P1-(nicotinamide-riboside-5')-P4-(adenosine-5')-tetraphosphate pH 7.5, 37°C, isozyme NMNAT1, versus substrate NMN Homo sapiens
2.7.7.1 0.0315
-
 P1-(adenosine-5')-P3-(nicotinamide-riboside-5')-triphosphate substrate: NMN, isoenzyme: NMNAT2 Homo sapiens
2.7.7.1 0.0315
-
 P1-(nicotinamide-riboside-5')-P3-(adenosine-5')-triphosphate pH 7.5, 37°C, isozyme NMNAT2, versus substrate NMN Homo sapiens
2.7.7.1 0.0328
-
 P1-(adenosine-5')-P3-(nicotinic-acid-riboside-5')-triphosphate substrate: ATP, isoenzyme: NMNAT3 Homo sapiens
2.7.7.1 0.0328
-
 P1-(nicotinate-riboside-5')-P4-(adenosine-5')-tetraphosphate pH 7.5, 37°C, isozyme NMNAT3, versus substrate ATP Homo sapiens
2.7.7.1 0.0359
-
 P1-(adenosine-5')-P3-(nicotinamide-riboside-5')-triphosphate substrate: ATP, isoenzyme: NMNAT2 Homo sapiens
2.7.7.1 0.0359
-
 P1-(nicotinamide-riboside-5')-P3-(adenosine-5')-triphosphate pH 7.5, 37°C, isozyme NMNAT2, versus substrate ATP Homo sapiens
2.7.7.1 0.0369
-
 P1-(adenosine-5')-P4-(nicotinic-acid-riboside-5')-tetraphosphate substrate: NMN, isoenzyme: NMNAT1 Homo sapiens
2.7.7.1 0.0369
-
 P1-(nicotinate-riboside-5')-P4-(adenosine-5')-tetraphosphate pH 7.5, 37°C, isozyme NMNAT1, versus substrate NaMN Homo sapiens
2.7.7.1 0.0406
-
 P1-(adenosine-5')-P3-(nicotinamide-riboside-5')-triphosphate substrate: ATP, isoenzyme: NMNAT3 Homo sapiens
2.7.7.1 0.0406
-
 P1-(nicotinamide-riboside-5')-P3-(adenosine-5')-triphosphate pH 7.5, 37°C, isozyme NMNAT3, versus substrate ATP Homo sapiens
2.7.7.1 0.041
-
 NaAD+ product inhibition of NMNAT2, substrate NMN Homo sapiens
2.7.7.1 0.0431
-
 P1-(adenosine-5')-P4-(nicotinic-acid-riboside-5')-tetraphosphate substrate: ATP, isoenzyme: NMNAT3 Homo sapiens
2.7.7.1 0.0431
-
 P1-(nicotinate-riboside-5')-P4-(adenosine-5')-tetraphosphate pH 7.5, 37°C, isozyme NMNAT3, versus substrate ATP Homo sapiens
2.7.7.1 0.0492
-
 P1-(adenosine-5')-P4-(nicotinamide-riboside-5')-tetraphosphate substrate: ATP, isoenzyme: NMNAT1 Homo sapiens
2.7.7.1 0.0492
-
 P1-(nicotinamide-riboside-5')-P4-(adenosine-5')-tetraphosphate pH 7.5, 37°C, isozyme NMNAT1, versus substrate ATP Homo sapiens
2.7.7.1 0.0563
-
 P1-(adenosine-5')-P3-(nicotinamide-riboside-5')-triphosphate substrate: ATP, isoenzyme: NMNAT1 Homo sapiens
2.7.7.1 0.0563
-
 P1-(nicotinamide-riboside-5')-P3-(adenosine-5')-triphosphate pH 7.5, 37°C, isozyme NMNAT1, versus substrate ATP Homo sapiens
2.7.7.1 0.0591
-
 P1-(adenosine-5')-P3-(nicotinic-acid-riboside-5')-triphosphate substrate: ATP, isoenzyme: NMNAT1 Homo sapiens
2.7.7.1 0.0591
-
 P1-(nicotinate-riboside-5')-P4-(adenosine-5')-tetraphosphate pH 7.5, 37°C, isozyme NMNAT1, versus substrate ATP Homo sapiens
2.7.7.1 0.0668
-
 P1-(adenosine-5')-P3-(nicotinamide-riboside-5')-triphosphate substrate: NMN, isoenzyme: NMNAT3 Homo sapiens
2.7.7.1 0.0668
-
 P1-(nicotinamide-riboside-5')-P3-(adenosine-5')-triphosphate pH 7.5, 37°C, isozyme NMNAT3, versus substrate NMN Homo sapiens
2.7.7.1 0.067
-
 NAD+ product inhibition of NMNAT2, substrate NMN Homo sapiens
2.7.7.1 0.0679
-
 P1-(adenosine-5')-P3-(nicotinic-acid-riboside-5')-triphosphate substrate: NMN, isoenzyme: NMNAT1 Homo sapiens
2.7.7.1 0.0679
-
 P1-(nicotinate-riboside-5')-P4-(adenosine-5')-tetraphosphate pH 7.5, 37°C, isozyme NMNAT1, versus substrate NMN Homo sapiens
2.7.7.1 0.0736
-
 P1-(adenosine-5')-P4-(nicotinamide-riboside-5')-tetraphosphate substrate: NMN, isoenzyme: NMNAT3 Homo sapiens
2.7.7.1 0.0736
-
 P1-(nicotinamide-riboside-5')-P4-(adenosine-5')-tetraphosphate pH 7.5, 37°C, isozyme NMNAT3, versus substrate NMN Homo sapiens
2.7.7.1 0.0845
-
 P1-(adenosine-5')-P4-(nicotinic-acid-riboside-5')-tetraphosphate substrate: ATP, isoenzyme: NMNAT1 Homo sapiens
2.7.7.1 0.0845
-
 P1-(nicotinate-riboside-5')-P4-(adenosine-5')-tetraphosphate pH 7.5, 37°C, isozyme NMNAT1, versus substrate ATP Homo sapiens
2.7.7.1 0.0883
-
 P1-(adenosine-5')-P3-(nicotinic-acid-riboside-5')-triphosphate substrate: NMN, isoenzyme: NMNAT3 Homo sapiens
2.7.7.1 0.0883
-
 P1-(nicotinate-riboside-5')-P4-(adenosine-5')-tetraphosphate pH 7.5, 37°C, isozyme NMNAT3, versus substrate NMN Homo sapiens
2.7.7.1 0.089
-
 P1-(adenosine-5')-P3-(nicotinamide-riboside-5')-triphosphate substrate: NMN, isoenzyme: NMNAT1 Homo sapiens
2.7.7.1 0.089
-
 P1-(nicotinamide-riboside-5')-P3-(adenosine-5')-triphosphate pH 7.5, 37°C, isozyme NMNAT1, versus substrate NMN Homo sapiens
2.7.7.1 0.095
-
 NAD+ product inhibition of NMNAT2, substrate ATP Homo sapiens
2.7.7.1 0.1257
-
 P1-(adenosine-5')-P4-(nicotinic-acid-riboside-5')-tetraphosphate substrate: NMN, isoenzyme: NMNAT2 Homo sapiens
2.7.7.1 0.1257
-
 P1-(nicotinate-riboside-5')-P4-(adenosine-5')-tetraphosphate pH 7.5, 37°C, isozyme NMNAT2, versus substrate NaMN Homo sapiens
2.7.7.1 0.16
-
 diphosphate product inhibition of NMNAT2, substrate NMN Homo sapiens
2.7.7.1 0.1745
-
 P1-(adenosine-5')-P3-(nicotinic-acid-riboside-5')-triphosphate substrate: ATP, isoenzyme: NMNAT2 Homo sapiens
2.7.7.1 0.1745
-
 P1-(nicotinate-riboside-5')-P4-(adenosine-5')-tetraphosphate pH 7.5, 37°C, isozyme NMNAT2, versus substrate ATP Homo sapiens
2.7.7.1 0.175
-
 diphosphate product inhibition of NMNAT1, substrate ATP Homo sapiens
2.7.7.1 0.205
-
 NaAD+ product inhibition of NMNAT3, substrate ATP Homo sapiens
2.7.7.1 0.305
-
 NaAD+ product inhibition of NMNAT1, substrate ATP Homo sapiens
2.7.7.1 0.3283
-
 P1-(adenosine-5')-P3-(nicotinic-acid-riboside-5')-triphosphate substrate: NMN, isoenzyme: NMNAT2 Homo sapiens
2.7.7.1 0.3283
-
 P1-(nicotinate-riboside-5')-P4-(adenosine-5')-tetraphosphate pH 7.5, 37°C, isozyme NMNAT2, versus substrate NMN Homo sapiens
2.7.7.1 0.334
-
 diphosphate product inhibition of NMNAT3, substrate ATP Homo sapiens
2.7.7.1 0.361
-
 diphosphate product inhibition of NMNAT2, substrate ATP Homo sapiens
2.7.7.1 0.364
-
 NaAD+ product inhibition of NMNAT3, substrate NMN Homo sapiens
2.7.7.1 0.39
-
 diphosphate product inhibition of NMNAT1, substrate NMN Homo sapiens
2.7.7.1 0.418
-
 NAD+ product inhibition of NMNAT1, substrate NMN Homo sapiens
2.7.7.1 0.502
-
 NaAD+ product inhibition of NMNAT1, substrate NMN Homo sapiens
2.7.7.1 0.6576
-
 P1-(adenosine-5')-P4-(nicotinic-acid-riboside-5')-tetraphosphate substrate: ATP, isoenzyme: NMNAT2 Homo sapiens
2.7.7.1 0.6576
-
 P1-(nicotinate-riboside-5')-P4-(adenosine-5')-tetraphosphate pH 7.5, 37°C, isozyme NMNAT2, versus substrate ATP Homo sapiens
2.7.7.1 0.749
-
 NAD+ product inhibition of NMNAT1, substrate ATP Homo sapiens
2.7.7.1 1
-
 diphosphate product inhibition of NMNAT3, substrate NMN Homo sapiens
2.7.7.1 1.017
-
 NAD+ product inhibition of NMNAT3, substrate NMN Homo sapiens
2.7.7.1 1.418
-
 NAD+ product inhibition of NMNAT3, substrate ATP Homo sapiens