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Literature summary extracted from

  • Juda, G.A.; Shepard, E.M.; Elmore, B.O.; Dooley, D.M.
    A comparative study of the binding and inhibition of four copper-containing amine oxidases by azide: implications for the role of copper during the oxidative half-reaction (2006), Biochemistry, 45, 8788-8800.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.22 azide noncompetitive with respect to oxidative half-reaction, noncompetitive with respect to reductive half-reaction Arthrobacter globiformis
1.4.3.22 azide partially competitive with respect to oxidative half-reaction, competitive with respect to reductive half-reaction Homo sapiens
1.4.3.22 azide mode of inhibition is dependent of azide concentration with respect to oxidative half-reaction, noncompetitive with respect to reductive half-reaction Komagataella pastoris
1.4.3.22 azide competitive with respect to oxidative half-reaction, noncompetitive with respect to reductive half-reaction Pisum sativum

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.4.3.22 0.0015
-
 Phenylethylamine 30°C, pH 7.2 Arthrobacter globiformis
1.4.3.22 0.014
-
 O2 30°C, pH 7.2 Homo sapiens
1.4.3.22 0.026
-
 putrescine 30°C, pH 7.2 Homo sapiens
1.4.3.22 0.033
-
 O2 30°C, pH 7.2 Arthrobacter globiformis
1.4.3.22 0.039
-
 Phenylethylamine 30°C, pH 7.0 Komagataella pastoris
1.4.3.22 0.041
-
 O2 30°C, pH 7.0 Komagataella pastoris
1.4.3.22 0.046
-
 O2 30°C, pH 7.2 Pisum sativum
1.4.3.22 0.424
-
 putrescine 30°C, pH 7.2 Pisum sativum

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.22 Arthrobacter globiformis
-
-
-
1.4.3.22 Homo sapiens
-
 recombinant
-
1.4.3.22 Komagataella pastoris
-
-
-
1.4.3.22 Pisum sativum
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.3.22 seedling
-
 Pisum sativum
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.22 2-phenylethylamine + H2O + O2
-
 Arthrobacter globiformis 2-phenylethanal + NH3 + H2O2
-
 ?
1.4.3.22 2-phenylethylamine + H2O + O2
-
 Komagataella pastoris phenylacetaldehyde + NH3 + H2O2
-
 r
1.4.3.22 benzylamine + H2O + O2
-
 Komagataella pastoris benzaldehyde + NH3 + H2O2
-
 ?
1.4.3.22 phenylethylamine + H2O + O2
-
 Komagataella pastoris phenylacetaldehyde + NH3 + H2O2
-
 r
1.4.3.22 putrescine + H2O + O2
-
 Homo sapiens ?
-
 ?
1.4.3.22 putrescine + H2O + O2
-
 Pisum sativum ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.4.3.22 AGAO
-
 Arthrobacter globiformis
1.4.3.22 PPLO
-
 Komagataella pastoris
1.4.3.22 PSAO
-
 Pisum sativum
1.4.3.22 rhDAO
-
 Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.4.3.22 0.308
-
 O2 30°C, pH 7.2, per dimer Pisum sativum
1.4.3.22 4
-
 O2 30°C, pH 7.2, per dimer Homo sapiens
1.4.3.22 7.9
-
 putrescine 30°C, pH 7.2, per dimer Homo sapiens
1.4.3.22 11.2
-
 2-Phenylethylamine 30°C, pH 7.0, per dimer Komagataella pastoris
1.4.3.22 12.6
-
 O2 30°C, pH 7.0, per dimer Komagataella pastoris
1.4.3.22 44
-
 2-Phenylethylamine 30°C, pH 7.2, per dimer Arthrobacter globiformis
1.4.3.22 53
-
 O2 30°C, pH 7.2, per dimer Arthrobacter globiformis
1.4.3.22 252
-
 putrescine 30°C, pH 7.2, per dimer Pisum sativum

Cofactor

EC Number Cofactor Comment Organism Structure
1.4.3.22 2,4,5-trihydroxyphenylalanine quinone i.e. iminoquinone, content of 2,4,5-trihydroxyphenylalanine quinone per dimer is 1.4 Homo sapiens
1.4.3.22 2,4,5-trihydroxyphenylalanine quinone i.e. iminoquinone, content of 2,4,5-trihydroxyphenylalanine quinone per dimer is 1.4 Arthrobacter globiformis
1.4.3.22 2,4,5-trihydroxyphenylalanine quinone i.e. iminoquinone, content of 2,4,5-trihydroxyphenylalanine quinone per dimer is 1.6 Komagataella pastoris
1.4.3.22 2,4,5-trihydroxyphenylalanine quinone i.e. iminoquinone, content of 2,4,5-trihydroxyphenylalanine quinone per dimer is 1.8 Pisum sativum

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.4.3.22 18
-
 azide 30°C, pH 7.2, with respect to reductive half-reaction Arthrobacter globiformis
1.4.3.22 19
-
 azide 30°C, pH 7.2, with respect to oxidative half-reaction Arthrobacter globiformis
1.4.3.22 23
-
 azide 30°C, pH 7.0, with respect to oxidative half-reaction Komagataella pastoris
1.4.3.22 26
-
 azide 30°C, pH 7.0, with respect to reductive half-reaction Komagataella pastoris
1.4.3.22 31
-
 azide 30°C, pH 7.2, with respect to oxidative half-reaction Pisum sativum
1.4.3.22 37
-
 azide 30°C, pH 7.2, with respect to reductive half-reaction Homo sapiens
1.4.3.22 92
-
 azide 30°C, pH 7.2, with respect to oxidative half-reaction Homo sapiens
1.4.3.22 250
-
 azide 30°C, pH 7.2, with respect to reductive half-reaction Pisum sativum