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Literature summary extracted from

  • Rogge, C.E.; Ho, B.; Liu, W.; Kulmacz, R.J.; Tsai, A.L.
    Role of Tyr348 in Tyr385 radical dynamics and cyclooxygenase inhibitor interactions in prostaglandin H synthase-2 (2006), Biochemistry, 45, 523-532.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.99.1 into the pVL1393 vector Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
1.14.99.1 Y348F mutant Homo sapiens
1.14.99.1 Y348F/Y504F mutant Homo sapiens
1.14.99.1 Y504F mutant Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.99.1 aspirin
-
Homo sapiens
1.14.99.1 nimesulide
-
Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.99.1 0.0021
-
arachidonic acid wild-type, cyclooxygenase activity Homo sapiens
1.14.99.1 0.0034
-
arachidonic acid mutant Y348F/Y504F, cyclooxygenase activity Homo sapiens
1.14.99.1 0.0038
-
arachidonic acid mutant Y348F, cyclooxygenase activity Homo sapiens
1.14.99.1 0.0042
-
arachidonic acid mutant Y504F, cyclooxygenase activity Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.99.1 membrane
-
Homo sapiens 16020
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.14.99.1 73000
-
determined by SDS-PAGE and immunoblotting Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.99.1 arachidonate + AH2 + O2 Homo sapiens
-
prostaglandin H2 + A + H2O
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.14.99.1 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.14.99.1
-
Homo sapiens

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.14.99.1 0.0027
-
mutant Y348F, cyclooxygenase activity Homo sapiens
1.14.99.1 0.0039
-
mutant Y504F, cyclooxygenase activity Homo sapiens
1.14.99.1 0.0047
-
mutant Y348F/Y504F, cyclooxygenase activity Homo sapiens
1.14.99.1 0.0058
-
wild-type, cyclooxygenase activity Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.99.1 arachidonate + AH2 + O2
-
Homo sapiens prostaglandin H2 + A + H2O
-
?

Synonyms

EC Number Synonyms Comment Organism
1.14.99.1 hPGHS-2
-
Homo sapiens
1.14.99.1 PGHS
-
Homo sapiens
1.14.99.1 PGHS-2
-
Homo sapiens
1.14.99.1 prostaglandin H synthase
-
Homo sapiens
1.14.99.1 prostaglandin H synthase-2
-
Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.14.99.1 22
-
lipoxygenase activity assay at room temperature Homo sapiens
1.14.99.1 30
-
cyclooxygenase activity assay Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.14.99.1 8
-
lipoxygenase activity assay Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.99.1 heme
-
Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.14.99.1 0.00027
-
nimesulide mutant Y348F/Y504F, cyclooxygenase inhibition Homo sapiens
1.14.99.1 0.0009
-
nimesulide mutant Y504F, cyclooxygenase inhibition Homo sapiens
1.14.99.1 0.001
-
nimesulide wild-type, cyclooxygenase inhibition Homo sapiens