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Literature summary extracted from

  • Duval, R.A.; Lewin, G.; Peris, E.; Chahboune, N.; Garofano, A.; Droese, S.; Cortes, D.; Brandt, U.; Hocquemiller, R.
    Heterocyclic analogues of squamocin as inhibitors of mitochondrial complex I. On the role of the terminal lactone of annonaceous acetogenins (2006), Biochemistry, 45, 2721-2728.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.1.1.2 1-Geranyl-2-methylbenzimidazole 0.001 mM, 87% inhibition Bos taurus
7.1.1.2 2-n-decyl-4-quinazolinylamine 0.001 mM, 73% inhibition Bos taurus
7.1.1.2 37-methoxyquinoxalinone IC50: 10 nM Bos taurus
7.1.1.2 39-pyridopyrazinone IC50: 17 nM Bos taurus
7.1.1.2 benzimidazole 0.001 mM, 72% inhibition Bos taurus
7.1.1.2 benzoxazinone 0.001 mM, 76% inhibition Bos taurus
7.1.1.2 imidazole 0.001 mM, 75% inhibition Bos taurus
7.1.1.2 Myxothiazol IC50: 170 nM Bos taurus
7.1.1.2 quinoxalinone 0.001 mM, 79% inhibition Bos taurus
7.1.1.2 rolliniastatin-2 0.001 mM, 92% inhibition Bos taurus
7.1.1.2 rotenone 0.001 mM, 90% inhibition Bos taurus
7.1.1.2 squamocin 0.001 mM, 88% inhibition Bos taurus
7.1.1.2 squamocin-quinoxalinone
-
 Bos taurus
7.1.1.2 squamocin-triazine
-
 Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.1.1.2 mitochondrion
-
 Bos taurus 5739
-

Organism

EC Number Organism UniProt Comment Textmining
7.1.1.2 Bos taurus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.1.1.2 NADH + n-decylubiquinone + H+
-
 Bos taurus NAD+ + n-decylubiquinol
-
 ?
7.1.1.2 NADH + ubiquinone
-
 Bos taurus NAD+ + ubiquinol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.1.1.2 complex I
-
 Bos taurus
7.1.1.2 NADH-ubiquinone oxidoreductase
-
 Bos taurus

Cofactor

EC Number Cofactor Comment Organism Structure
7.1.1.2 NADH
-
 Bos taurus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
7.1.1.2 0.00001
-
 IC50: 10 nM Bos taurus 37-methoxyquinoxalinone
7.1.1.2 0.000017
-
 IC50: 17 nM Bos taurus 39-pyridopyrazinone
7.1.1.2 0.00017
-
 IC50: 170 nM Bos taurus Myxothiazol