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Literature summary extracted from

  • Hartman, H.L.; Hicks, K.A.; Fierke, C.A.
    Peptide specificity of protein prenyltransferases is determined mainly by reactivity rather than binding affinity (2005), Biochemistry, 44, 15314-15324.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.5.1.58 expressed in Escherichia coli BL21(DE3) FPT/pET23a cells Rattus norvegicus
2.5.1.59 expressed in Escherichia coli strain BL21(DE3) GGPT/pET23a Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.58 Rattus norvegicus
-
-
-
2.5.1.59 Escherichia coli
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.5.1.58
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.58 farnesyl diphosphate + protein-cysteine
-
 Rattus norvegicus diphosphate + S-farnesyl protein
-
 ?
2.5.1.58 TKCVIA + farnesyl diphosphate
-
 Rattus norvegicus TK-(S-farnesyl)CVIA + diphosphate
-
 ?
2.5.1.58 TKCVIC + farnesyl diphosphate
-
 Rattus norvegicus diphosphate + ?
-
 ?
2.5.1.58 TKCVID + farnesyl diphosphate
-
 Rattus norvegicus TK-(S-farnesyl)CVID + diphosphate
-
 ?
2.5.1.58 TKCVIF + farnesyl diphosphate
-
 Rattus norvegicus TK-(S-farnesyl)CVIF + diphosphate
-
 ?
2.5.1.58 TKCVII + farnesyl diphosphate
-
 Rattus norvegicus TK-(S-farnesyl)CVII + diphosphate
-
 ?
2.5.1.58 TKCVIL + farnesyl diphosphate
-
 Rattus norvegicus TK-(S-farnesyl)CVIL + diphosphate
-
 ?
2.5.1.58 TKCVIM + farnesyl diphosphate
-
 Rattus norvegicus TK-(S-farnesyl)CVIM + diphosphate
-
 ?
2.5.1.58 TKCVIN + farnesyl diphosphate
-
 Rattus norvegicus TK-(S-farnesyl)CVIN + diphosphate
-
 ?
2.5.1.58 TKCVIQ + farnesyl diphosphate
-
 Rattus norvegicus TK-(S-farnesyl)CVIQ + diphosphate
-
 ?
2.5.1.58 TKCVIR + farnesyl diphosphate
-
 Rattus norvegicus TK-(S-farnesyl)CVIR + diphosphate
-
 ?
2.5.1.58 TKCVIS + farnesyl diphosphate
-
 Rattus norvegicus TK-(S-farnesyl)CVIS + diphosphate
-
 ?
2.5.1.58 TKCVIT + farnesyl diphosphate
-
 Rattus norvegicus TK-(S-farnesyl)CVIT + diphosphate
-
 ?
2.5.1.58 TKCVIV + farnesyl diphosphate
-
 Rattus norvegicus TK-(S-farnesyl)CVIV + diphosphate
-
 ?
2.5.1.58 TKCVIY + farnesyl diphosphate
-
 Rattus norvegicus TK-(S-farnesyl)CVIY + diphosphate
-
 ?
2.5.1.59 geranylgeranyl diphosphate + Ki-Ras4B
-
 Escherichia coli diphosphate + S-geranylgeranyl-Ki-Ras4B
-
 ?
2.5.1.59 geranylgeranyl diphosphate + Thr-Lys-Cys-Val-Ile-Ala
-
 Escherichia coli diphosphate + Thr-Lys-(S-geranylgeranyl)-Cys-Val-Ile-Ala
-
 ?
2.5.1.59 geranylgeranyl diphosphate + Thr-Lys-Cys-Val-Ile-Arg
-
 Escherichia coli diphosphate + Thr-Lys-(S-geranylgeranyl)-Cys-Val-Ile-Arg
-
 ?
2.5.1.59 geranylgeranyl diphosphate + Thr-Lys-Cys-Val-Ile-Asn
-
 Escherichia coli diphosphate + Thr-Lys-(S-geranylgeranyl)-Cys-Val-Ile-Asn
-
 ?
2.5.1.59 geranylgeranyl diphosphate + Thr-Lys-Cys-Val-Ile-Asp
-
 Escherichia coli diphosphate + Thr-Lys-(S-geranylgeranyl)-Cys-Val-Ile-Asp
-
 ?
2.5.1.59 geranylgeranyl diphosphate + Thr-Lys-Cys-Val-Ile-Cys
-
 Escherichia coli diphosphate + Thr-Lys-(S-geranylgeranyl)-Cys-Val-Ile-Cys
-
 ?
2.5.1.59 geranylgeranyl diphosphate + Thr-Lys-Cys-Val-Ile-Gln
-
 Escherichia coli diphosphate + Thr-Lys-(S-geranylgeranyl)-Cys-Val-Ile-Gln
-
 ?
2.5.1.59 geranylgeranyl diphosphate + Thr-Lys-Cys-Val-Ile-Ile
-
 Escherichia coli diphosphate + Thr-Lys-(S-geranylgeranyl)-Cys-Val-Ile-Ile
-
 ?
2.5.1.59 geranylgeranyl diphosphate + Thr-Lys-Cys-Val-Ile-Leu
-
 Escherichia coli diphosphate + Thr-Lys-(S-geranylgeranyl)-Cys-Val-Ile-Leu
-
 ?
2.5.1.59 geranylgeranyl diphosphate + Thr-Lys-Cys-Val-Ile-Met
-
 Escherichia coli diphosphate + Thr-Lys-(S-geranylgeranyl)-Cys-Val-Ile-Met
-
 ?
2.5.1.59 geranylgeranyl diphosphate + Thr-Lys-Cys-Val-Ile-Phe
-
 Escherichia coli diphosphate + Thr-Lys-(S-geranylgeranyl)-Cys-Val-Ile-Phe
-
 ?
2.5.1.59 geranylgeranyl diphosphate + Thr-Lys-Cys-Val-Ile-Ser
-
 Escherichia coli diphosphate + Thr-Lys-(S-geranylgeranyl)-Cys-Val-Ile-Ser
-
 ?
2.5.1.59 geranylgeranyl diphosphate + Thr-Lys-Cys-Val-Ile-Thr
-
 Escherichia coli diphosphate + Thr-Lys-(S-geranylgeranyl)-Cys-Val-Ile-Thr
-
 ?
2.5.1.59 geranylgeranyl diphosphate + Thr-Lys-Cys-Val-Ile-Tyr
-
 Escherichia coli diphosphate + Thr-Lys-(S-geranylgeranyl)-Cys-Val-Ile-Tyr
-
 ?
2.5.1.59 geranylgeranyl diphosphate + Thr-Lys-Cys-Val-Ile-Val
-
 Escherichia coli diphosphate + Thr-Lys-(S-geranylgeranyl)-Cys-Val-Ile-Val
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.58 FTase
-
 Rattus norvegicus
2.5.1.58 protein prenyltransferase
-
 Rattus norvegicus
2.5.1.59 GGTaseI
-
 Escherichia coli
2.5.1.59 protein geranylgeranyltransferase type I
-
 Escherichia coli

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.5.1.58 0.0005
-
 TKCVID
-
 Rattus norvegicus
2.5.1.58 0.001
-
 TKCVII
-
 Rattus norvegicus
2.5.1.58 0.001
-
 TKCVIL
-
 Rattus norvegicus
2.5.1.58 0.001
-
 TKCVIR
-
 Rattus norvegicus
2.5.1.58 0.0017
-
 TKCVIY
-
 Rattus norvegicus
2.5.1.58 0.0021
-
 TKCVIV
-
 Rattus norvegicus
2.5.1.58 0.0082
-
 TKCVIF
-
 Rattus norvegicus
2.5.1.58 0.013
-
 TKCVIN
-
 Rattus norvegicus
2.5.1.58 0.017
-
 TKCVIT
-
 Rattus norvegicus
2.5.1.58 0.041
-
 TKCVIM
-
 Rattus norvegicus
2.5.1.58 0.046
-
 TKCVIA in 50 mM N2-hydroxyethylpiperazine-N-2-hydroxypropanesulfonic acid-NaOH, pH 7.8, 5 mM MgCl2, and 2 mM tris(2-carboxyethyl)phosphine hydrochloride Rattus norvegicus
2.5.1.58 0.161
-
 TKCVIQ
-
 Rattus norvegicus
2.5.1.58 0.21
-
 TKCVIS
-
 Rattus norvegicus
2.5.1.58 0.31
-
 TKCVIC
-
 Rattus norvegicus
2.5.1.59 0.001
-
 Thr-Lys-Cys-Val-Ile-Ser in 50 mM Tris-HCl, 5 mM dithiothreitol, 5 mM MgCl2, and 0.01 mM ZnCl2 Escherichia coli
2.5.1.59 0.001
-
 Thr-Lys-Cys-Val-Ile-Ala in 50 mM Tris-HCl, 5 mM dithiothreitol, 5 mM MgCl2, and 0.01 mM ZnCl2 Escherichia coli
2.5.1.59 0.001
-
 Thr-Lys-Cys-Val-Ile-Asp in 50 mM Tris-HCl, 5 mM dithiothreitol, 5 mM MgCl2, and 0.01 mM ZnCl2 Escherichia coli
2.5.1.59 0.001
-
 Thr-Lys-Cys-Val-Ile-Asn in 50 mM Tris-HCl, 5 mM dithiothreitol, 5 mM MgCl2, and 0.01 mM ZnCl2 Escherichia coli
2.5.1.59 0.001
-
 Thr-Lys-Cys-Val-Ile-Gln in 50 mM Tris-HCl, 5 mM dithiothreitol, 5 mM MgCl2, and 0.01 mM ZnCl2 Escherichia coli
2.5.1.59 0.001
-
 Thr-Lys-Cys-Val-Ile-Arg in 50 mM Tris-HCl, 5 mM dithiothreitol, 5 mM MgCl2, and 0.01 mM ZnCl2 Escherichia coli
2.5.1.59 0.001
-
 Thr-Lys-Cys-Val-Ile-Thr in 50 mM Tris-HCl, 5 mM dithiothreitol, 5 mM MgCl2, and 0.01 mM ZnCl2 Escherichia coli
2.5.1.59 0.0063
-
 Thr-Lys-Cys-Val-Ile-Cys in 50 mM Tris-HCl, 5 mM dithiothreitol, 5 mM MgCl2, and 0.01 mM ZnCl2 Escherichia coli
2.5.1.59 0.022
-
 Thr-Lys-Cys-Val-Ile-Tyr in 50 mM Tris-HCl, 5 mM dithiothreitol, 5 mM MgCl2, and 0.01 mM ZnCl2 Escherichia coli
2.5.1.59 0.048
-
 Thr-Lys-Cys-Val-Ile-Ile in 50 mM Tris-HCl, 5 mM dithiothreitol, 5 mM MgCl2, and 0.01 mM ZnCl2 Escherichia coli
2.5.1.59 0.06
-
 Thr-Lys-Cys-Val-Ile-Phe in 50 mM Tris-HCl, 5 mM dithiothreitol, 5 mM MgCl2, and 0.01 mM ZnCl2 Escherichia coli
2.5.1.59 0.082
-
 Thr-Lys-Cys-Val-Ile-Met in 50 mM Tris-HCl, 5 mM dithiothreitol, 5 mM MgCl2, and 0.01 mM ZnCl2 Escherichia coli
2.5.1.59 0.088
-
 Thr-Lys-Cys-Val-Ile-Leu in 50 mM Tris-HCl, 5 mM dithiothreitol, 5 mM MgCl2, and 0.01 mM ZnCl2 Escherichia coli
2.5.1.59 0.107
-
 Thr-Lys-Cys-Val-Ile-Val in 50 mM Tris-HCl, 5 mM dithiothreitol, 5 mM MgCl2, and 0.01 mM ZnCl2 Escherichia coli