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Literature summary extracted from

  • Heldt, D.; Lawrence, A.D.; Lindenmeyer, M.; Deery, E.; Heathcote, P.; Rigby, S.E.; Warren, M.J.
    Aerobic synthesis of vitamin B12: ring contraction and cobalt chelation (2005), Biochem. Soc. Trans., 33, 815-819.
    View publication on PubMed

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.13.83 Fe2+ the enzyme contains both a non-haem iron and an Fe-S centre Rhodobacter capsulatus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.13.83 precorrin-3A + NADH + O2 Rhodobacter capsulatus the enzyme is involved in ring contraction, whereby an integral carbon atom of the tetrapyrrole-derived macrocycle is removed, and cobalt chelation during aerobic synthesis of vitamin B12, the catalytic cycle of CobZ, overview precorrin-3B + NAD+ + H2O
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 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.13.83 Rhodobacter capsulatus
-
 in bacteria such as Rhodobacter capsulatus CobG is substituted by an isofunctional protein called CobZ
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Reaction

EC Number Reaction Comment Organism Reaction ID
1.14.13.83 precorrin-3A + NADH + H+ + O2 = precorrin-3B + NAD+ + H2O reaction mechanism of CobZ Rhodobacter capsulatus
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.13.83 precorrin-3A + NADH + O2 the enzyme is involved in ring contraction, whereby an integral carbon atom of the tetrapyrrole-derived macrocycle is removed, and cobalt chelation during aerobic synthesis of vitamin B12, the catalytic cycle of CobZ, overview Rhodobacter capsulatus precorrin-3B + NAD+ + H2O
-
 ?
1.14.13.83 precorrin-3A + NADH + O2 the enzyme generates a hydroxy lactone intermediate Rhodobacter capsulatus precorrin-3B + NAD+ + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.13.83 CobZ
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 Rhodobacter capsulatus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.13.83 flavin enzyme-bound Rhodobacter capsulatus