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Literature summary extracted from

  • Smal, C.; Cardoen, S.; Betrand, L.; Delacauw, A.; Ferrant, A.; Van den Berghe, G.; Van den Neste, E.; Bontemps, F.
    Activation of deoxycytidine kinase by protein kinase inhibitors and okadaic acid in leukemic cells (2003), Biochem. Pharmacol., 69, 95-103.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.74 2-chloro-2'-deoxyadenosine
-
 Homo sapiens
2.7.1.74 AG-490
-
 Homo sapiens
2.7.1.74 daidzein
-
 Homo sapiens
2.7.1.74 genistein
-
 Homo sapiens
2.7.1.74 okadaic acid
-
 Homo sapiens
2.7.1.74 PD-98059
-
 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.74 H-7 reduces the enzyme activation caused by the addition of 2-chloro-2’-deoxyadenosine Homo sapiens
2.7.1.74 protein phosphatase lambda
-
 Homo sapiens
2.7.1.74 staurosporine reduces the enzyme activation caused by the addition of 2-chloro-2’-deoxyadenosine Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.74 ATP + 2'-deoxyadenosine Homo sapiens rate-limiting reaction in the salvage of deoxyribonucleosides, supplying cells with deoxyribonucleotides for DNA replicative and repair synthesis ADP + 2'-deoxyadenosine 5'-phosphate
-
 ?
2.7.1.74 ATP + 2'-deoxycytidine Homo sapiens rate-limiting reaction in the salvage of deoxyribonucleosides, supplying cells with deoxyribonucleotides for DNA replicative and repair synthesis ADP + 2'-deoxycytidine 5'-phosphate
-
 ?
2.7.1.74 additional information Homo sapiens key enzyme in the deoxynucleoside salvage pathway and in the activation of numerous nucleoside analogues used in cancer and antiviral chemotherapy ?
-
 ?
2.7.1.74 NTP + 2-chloro-2'-deoxyadenosine Homo sapiens i.e. cladribine, activation of the pharmaceutically relevant substrate which is commonly used in the treatment of lymphoproliferative malignancies NDP + 2-chloro-2'-deoxyadenosine 5'-phosphate
-
 ?
2.7.1.74 NTP + 9-beta-D-arabinosyl 2-fluoroadenine Homo sapiens activation of the pharmaceutically relevant substrate which is commonly used in the treatment of lymphoproliferative malignancies NDP + 9-beta-D-arabinosyl 2-fluoroadenine 5'-phosphate
-
 ?
2.7.1.74 UTP + 2',3'-dideoxycytidine Homo sapiens i.e. zalcitabine, activation of the pharmaceutically relevant substrate which is used for the treatment of HIV infections UDP + 2',3'-dideoxycytidine 5'-phosphate
-
 ?
2.7.1.74 UTP + 2'-deoxy-3'-thiacytidine Homo sapiens i.e. lamivudine, activation of the pharmaceutically relevant substrate which is used for the treatment of HIV infections UDP + 2'-deoxy-3'-thiacytidine 5'-phosphate
-
 ?
2.7.1.74 UTP + 2'-deoxyadenosine Homo sapiens rate-limiting reaction in the salvage of deoxyribonucleosides, supplying cells with deoxyribonucleotides for DNA replicative and repair synthesis UDP + 2'-deoxyadenosine 5'-phosphate
-
 ?
2.7.1.74 UTP + 2'-deoxycytidine Homo sapiens rate-limiting reaction in the salvage of deoxyribonucleosides, supplying cells with deoxyribonucleotides for DNA replicative and repair synthesis UDP + 2'-deoxycytidine 5'-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.74 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.1.74 phosphoprotein phosphorylation of the enzyme involved in the regulation of enzyme activity Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.74 CCRF-CEM cell
-
 Homo sapiens
-
2.7.1.74 EHEB cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.74 ATP + 2'-deoxyadenosine rate-limiting reaction in the salvage of deoxyribonucleosides, supplying cells with deoxyribonucleotides for DNA replicative and repair synthesis Homo sapiens ADP + 2'-deoxyadenosine 5'-phosphate
-
 ?
2.7.1.74 ATP + 2'-deoxycytidine
-
 Homo sapiens ADP + 2'-deoxycytidine 5'-phosphate
-
 ?
2.7.1.74 ATP + 2'-deoxycytidine rate-limiting reaction in the salvage of deoxyribonucleosides, supplying cells with deoxyribonucleotides for DNA replicative and repair synthesis Homo sapiens ADP + 2'-deoxycytidine 5'-phosphate
-
 ?
2.7.1.74 additional information key enzyme in the deoxynucleoside salvage pathway and in the activation of numerous nucleoside analogues used in cancer and antiviral chemotherapy Homo sapiens ?
-
 ?
2.7.1.74 NTP + 2-chloro-2'-deoxyadenosine i.e. cladribine, activation of the pharmaceutically relevant substrate which is commonly used in the treatment of lymphoproliferative malignancies Homo sapiens NDP + 2-chloro-2'-deoxyadenosine 5'-phosphate
-
 ?
2.7.1.74 NTP + 9-beta-D-arabinosyl 2-fluoroadenine activation of the pharmaceutically relevant substrate which is commonly used in the treatment of lymphoproliferative malignancies Homo sapiens NDP + 9-beta-D-arabinosyl 2-fluoroadenine 5'-phosphate
-
 ?
2.7.1.74 UTP + 2',3'-dideoxycytidine i.e. zalcitabine, activation of the pharmaceutically relevant substrate which is used for the treatment of HIV infections Homo sapiens UDP + 2',3'-dideoxycytidine 5'-phosphate
-
 ?
2.7.1.74 UTP + 2'-deoxy-3'-thiacytidine i.e. lamivudine, activation of the pharmaceutically relevant substrate which is used for the treatment of HIV infections Homo sapiens UDP + 2'-deoxy-3'-thiacytidine 5'-phosphate
-
 ?
2.7.1.74 UTP + 2'-deoxyadenosine rate-limiting reaction in the salvage of deoxyribonucleosides, supplying cells with deoxyribonucleotides for DNA replicative and repair synthesis Homo sapiens UDP + 2'-deoxyadenosine 5'-phosphate
-
 ?
2.7.1.74 UTP + 2'-deoxycytidine rate-limiting reaction in the salvage of deoxyribonucleosides, supplying cells with deoxyribonucleotides for DNA replicative and repair synthesis Homo sapiens UDP + 2'-deoxycytidine 5'-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.74 dCK
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.74 ATP
-
 Homo sapiens
2.7.1.74 UTP
-
 Homo sapiens