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Literature summary extracted from

  • Bakovic, M.; Fullerton, M.D.; Michel, V.
    Metabolic and molecular aspects of ethanolamine phospholipid biosynthesis: the role of CTP:phosphoethanolamine cytidylyltransferase (Pcyt2) (2007), Biochem. Cell Biol., 85, 283-300.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.7.14 AMP-activated kinase
-
 Homo sapiens
2.7.7.14 AMP-activated kinase
-
 Rattus norvegicus
2.7.7.14 AMP-activated kinase
-
 Mus musculus
2.7.7.14 additional information does not require the presence of exogenous lipids for optimal activity Homo sapiens
2.7.7.14 additional information does not require the presence of exogenous lipids for optimal activity Rattus norvegicus
2.7.7.14 additional information does not require the presence of exogenous lipids for optimal activity Mus musculus
2.7.7.14 paramethoxyamphetamine stimulates activity Homo sapiens
2.7.7.14 paramethoxyamphetamine stimulates activity Rattus norvegicus
2.7.7.14 paramethoxyamphetamine stimulates activity Mus musculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.7.14
-
 Homo sapiens
2.7.7.14
-
 Rattus norvegicus
2.7.7.14
-
 Saccharomyces cerevisiae
2.7.7.14
-
 Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.14 aminoimidazole-4-carboxamide downregulates Pcyt2 activity Homo sapiens
2.7.7.14 aminoimidazole-4-carboxamide downregulates Pcyt2 activity Mus musculus
2.7.7.14 aminoimidazole-4-carboxamide downregulates Pcyt2 activity Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.7.14 0.053
-
 Ethanolamine phosphate
-
 Rattus norvegicus
2.7.7.14 0.065
-
 CTP
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.7.14 cytosol
-
 Homo sapiens 5829
-
2.7.7.14 cytosol
-
 Rattus norvegicus 5829
-
2.7.7.14 cytosol
-
 Mus musculus 5829
-
2.7.7.14 membrane associated with the membranes of the rough endoplasmic reticulum Homo sapiens 16020
-
2.7.7.14 membrane associated with the membranes of the rough endoplasmic reticulum Rattus norvegicus 16020
-
2.7.7.14 membrane associated with the membranes of the rough endoplasmic reticulum Mus musculus 16020
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.7.14 50000
-
 SDS-PAGE Homo sapiens
2.7.7.14 50000
-
 SDS-PAGE Rattus norvegicus
2.7.7.14 50000
-
 SDS-PAGE Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.14 Homo sapiens
-
-
-
2.7.7.14 Mus musculus Q922E4
-
-
2.7.7.14 Rattus norvegicus
-
-
-
2.7.7.14 Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.7.14
-
 Homo sapiens
2.7.7.14
-
 Rattus norvegicus
2.7.7.14
-
 Saccharomyces cerevisiae
2.7.7.14
-
 Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.7.14 adipocyte
-
 Homo sapiens
-
2.7.7.14 adipocyte
-
 Mus musculus
-
2.7.7.14 adipocyte high Pcyt2 mRNA content. Negligible amount of Pcyt2beta mRNA, high amount of Pcyt2alpha mRNA Mus musculus
-
2.7.7.14 brain low Pcyt2 mRNA content Mus musculus
-
2.7.7.14 heart
-
 Homo sapiens
-
2.7.7.14 heart
-
 Mus musculus
-
2.7.7.14 heart very low level of Pcyt2alpha Homo sapiens
-
2.7.7.14 kidney
-
 Homo sapiens
-
2.7.7.14 kidney
-
 Mus musculus
-
2.7.7.14 kidney negligible amount of Pcyt2beta mRNA, high amount of Pcyt2alpha mRNA Mus musculus
-
2.7.7.14 liver
-
 Homo sapiens
-
2.7.7.14 liver
-
 Rattus norvegicus
-
2.7.7.14 liver
-
 Mus musculus
-
2.7.7.14 liver low Pcyt2 mRNA content. Negligible amount of Pcyt2beta mRNA, high amount of Pcyt2alpha mRNA Mus musculus
-
2.7.7.14 liver Pcyt2 stays constant throughout the rat adult stage Rattus norvegicus
-
2.7.7.14 additional information Pcyt2 mRNA is barely detected in human kidney Homo sapiens
-
2.7.7.14 skeletal muscle low Pcyt2 mRNA content Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.14 CTP + ethanolamine phosphate
-
 Homo sapiens diphosphate + CDP-ethanolamine
-
 ?
2.7.7.14 CTP + ethanolamine phosphate
-
 Rattus norvegicus diphosphate + CDP-ethanolamine
-
 ?
2.7.7.14 CTP + ethanolamine phosphate
-
 Saccharomyces cerevisiae diphosphate + CDP-ethanolamine
-
 ?
2.7.7.14 CTP + ethanolamine phosphate
-
 Mus musculus diphosphate + CDP-ethanolamine
-
 ?
2.7.7.14 additional information uses N-methylated derivatives of ethanolamine phosphate less efficiently and does not react with phosphocholine Homo sapiens ?
-
 ?
2.7.7.14 additional information uses N-methylated derivatives of ethanolamine phosphate less efficiently and does not react with phosphocholine Rattus norvegicus ?
-
 ?
2.7.7.14 additional information uses N-methylated derivatives of ethanolamine phosphate less efficiently and does not react with phosphocholine Mus musculus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.7.14 dimer
-
 Homo sapiens
2.7.7.14 dimer
-
 Rattus norvegicus
2.7.7.14 dimer
-
 Mus musculus

Synonyms

EC Number Synonyms Comment Organism
2.7.7.14 CTP:phosphoethanolamine cytidylyltransferase
-
 Homo sapiens
2.7.7.14 CTP:phosphoethanolamine cytidylyltransferase
-
 Rattus norvegicus
2.7.7.14 CTP:phosphoethanolamine cytidylyltransferase
-
 Saccharomyces cerevisiae
2.7.7.14 CTP:phosphoethanolamine cytidylyltransferase
-
 Mus musculus
2.7.7.14 Pcyt2
-
 Homo sapiens
2.7.7.14 Pcyt2
-
 Rattus norvegicus
2.7.7.14 Pcyt2
-
 Saccharomyces cerevisiae
2.7.7.14 Pcyt2
-
 Mus musculus
2.7.7.14 Pcyt2alpha longer variant of Pcyt2 Homo sapiens
2.7.7.14 Pcyt2alpha longer variant of Pcyt2 Mus musculus
2.7.7.14 Pcyt2beta shorter variant of Pcyt2 Homo sapiens
2.7.7.14 Pcyt2beta shorter variant of Pcyt2 Mus musculus