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Literature summary extracted from

  • Azcarate-Peril, M.A.; Bruno-Barcena, J.M.; Hassan, H.M.; Klaenhammer, T.R.
    Transcriptional and functional analysis of oxalyl-coenzyme A (CoA) decarboxylase and formyl-CoA transferase genes from Lactobacillus acidophilus (2006), Appl. Environ. Microbiol., 72, 1891-1899.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.8.3.16 additional information oxalate induces the expression of genes frc and oxc Lactobacillus acidophilus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.8.3.16 gene frc, DNA and amino acid sequence determination and analysis, phylogenetic analysis Lactobacillus gasseri
2.8.3.16 gene frc, DNA and amino acid sequence determination and analysis, phylogenetic analysis Bifidobacterium animalis subsp. lactis
2.8.3.16 gene frc, organized in the oxc operon, DNA and amino acid sequence determination and analysis, transcriptional and quantitative expression analysis, mildly acidic conditions are a prerequisite for frc and oxc transcription, phylogenetic analysis Lactobacillus acidophilus

Protein Variants

EC Number Protein Variants Comment Organism
2.8.3.16 additional information construction of a frc deletion mutant, frc expression specifically improves survival in the presence of oxalic acid at pH 3.5, the frc mutant is unable to degrade oxalate, phenotype, overview Lactobacillus acidophilus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.3.16 formyl-CoA + oxalate Lactobacillus acidophilus the enzyme is required for oxalate degradation together with oxalyl-CoA decarboxylase, EC 4.1.1.8, overview formate + oxalyl-CoA
-
 ?
2.8.3.16 formyl-CoA + oxalate Lactobacillus acidophilus NCFM the enzyme is required for oxalate degradation together with oxalyl-CoA decarboxylase, EC 4.1.1.8, overview formate + oxalyl-CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.8.3.16 Bifidobacterium animalis subsp. lactis
-
 gene frc
-
2.8.3.16 Lactobacillus acidophilus
-
-
-
2.8.3.16 Lactobacillus acidophilus NCFM
-
-
-
2.8.3.16 Lactobacillus gasseri
-
 gene frc
-
4.1.1.8 Lactobacillus acidophilus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.3.16 formyl-CoA + oxalate
-
 Lactobacillus acidophilus formate + oxalyl-CoA
-
 ?
2.8.3.16 formyl-CoA + oxalate the enzyme is required for oxalate degradation together with oxalyl-CoA decarboxylase, EC 4.1.1.8, overview Lactobacillus acidophilus formate + oxalyl-CoA
-
 ?
2.8.3.16 formyl-CoA + oxalate
-
 Lactobacillus acidophilus NCFM formate + oxalyl-CoA
-
 ?
2.8.3.16 formyl-CoA + oxalate the enzyme is required for oxalate degradation together with oxalyl-CoA decarboxylase, EC 4.1.1.8, overview Lactobacillus acidophilus NCFM formate + oxalyl-CoA
-
 ?
4.1.1.8 Oxalyl-CoA
-
 Lactobacillus acidophilus Formyl-CoA + CO2
-
 ?
4.1.1.8 Oxalyl-CoA
-
 Lactobacillus acidophilus NCFM Formyl-CoA + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.1.8 oxalyl-coenzyme A decarboxylase
-
 Lactobacillus acidophilus

Cofactor

EC Number Cofactor Comment Organism Structure
4.1.1.8 thiamine diphosphate required Lactobacillus acidophilus