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Literature summary extracted from

  • de Brouwer, A.P.; Williams, K.L.; Duley, J.A.; van Kuilenburg, A.B.; Nabuurs, S.B.; Egmont-Petersen, M.; Lugtenberg, D.; Zoetekouw, L.; Banning, M.J.; Roeffen, M.; Hamel, B.C.; Weaving, L.; Ouvrier, R.A.; Donald, J.A.; Wevers, R.A.; Christodoulou, J.; van Bokhoven, H.
    Arts syndrome is caused by loss-of-function mutations in PRPS1 (2007), Am. J. Hum. Genet., 81, 507-518.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.6.1 diadenosine pentaphosphate Inhibits the dephosphorylation of ATP and ADP by nonspecific phosphatases. Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.6.1 ribose-5-phosphate + ATP Homo sapiens first step in purine metabolic pathway phosphoribosyldiphosphate + AMP
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.6.1 Homo sapiens P60891
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.6.1 EBV-LCL cell
-
 Homo sapiens
-
2.7.6.1 erythrocyte
-
 Homo sapiens
-
2.7.6.1 fibroblast
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.6.1 ribose-5-phosphate + ATP first step in purine metabolic pathway Homo sapiens phosphoribosyldiphosphate + AMP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.6.1 phosphoribosyl pyrophosphate synthase 1 (PRS-1)
-
 Homo sapiens