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Literature summary extracted from

  • Kotik-Kogan, O.; Moor, N.; Tworowski, D.; Safro, M.
    Structural basis for discrimination of L-phenylalanine from L-tyrosine by phenylalanyl-tRNA synthetase (2005), Structure, 13, 1799-1807.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
6.1.1.20 crystal structure of complexes of enzyme with L-Tyr, p-chlorophenylalanine, and L-tyrosyl-adenylate Thermus thermophilus

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.1.1.20 L-phenylalanyl-5'-adenylate
-
 Thermus thermophilus
6.1.1.20 L-Tyr
-
 Thermus thermophilus
6.1.1.20 L-tyrosyl-adenylate
-
 Thermus thermophilus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.1.1.20 0.0018
-
 L-Phe
-
 Thermus thermophilus
6.1.1.20 0.13
-
 ATP
-
 Thermus thermophilus

Organism

EC Number Organism UniProt Comment Textmining
6.1.1.20 Thermus thermophilus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.1.1.20 ATP + L-Phe + tRNAPhe
-
 Thermus thermophilus AMP + diphosphate + L-phenylalanyl-tRNAPhe
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.1.1.20 PheRS
-
 Thermus thermophilus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
6.1.1.20 0.043
-
 L-tyrosyl-adenylate versus ATP Thermus thermophilus
6.1.1.20 0.045
-
 L-tyrosyl-adenylate versus L-Phe Thermus thermophilus
6.1.1.20 0.085
-
 L-phenylalanyl-5'-adenylate versus ATP Thermus thermophilus
6.1.1.20 0.089
-
 L-phenylalanyl-5'-adenylate versus L-Phe Thermus thermophilus
6.1.1.20 3.1
-
 L-Tyr versus L-Phe Thermus thermophilus