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Literature summary extracted from
- Functional proteomics of resveratrol-induced colon cancer cell apoptosis: caspase-6-mediated cleavage of lamin A is a major signaling loop (2006), Proteomics, 6, 2386-2394.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.22.59 | resveratrol | induces caspase-6-dependent cleavage of lamin A | Homo sapiens |  |
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.4.22.59 | medicine | critical role of caspase-6 and its cleavage of lamin A in apoptotic signaling triggered by resveratrol in the colon carcinoma cells | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.22.59 | siRNA | silencing of caspase-6 expression | Homo sapiens | |
| 3.4.22.59 | Z-Val-Ala-Asp-fluoromethylketone | - |
Homo sapiens | |
| 3.4.22.59 | Z-VEID-fmk | - |
Homo sapiens | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.22.59 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.22.59 | HCT-116 cell | variants p53+, p53-, Bax+, Bax- | Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.22.59 | lamin A + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.22.59 | VEID-7-amido-4-trifluoromethylcoumarin + H2O | - |
Homo sapiens | VEID + 7-amino-4-trifluoromethylcoumarin | - |
? | |
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