BRENDA - Enzyme Database

Drs2p-coupled aminophospholipid translocase activity in yeast Golgi membranes and relationship to in vivo function

Natarajan, P.; Wang, J.; Hua, Z.; Graham, T.R.; Proc. Natl. Acad. Sci. USA 101, 10614-10619 (2004)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
7.6.2.1
protein Drs2p
coupled to the enzyme, required for the translocation of phospholipids from the luminal leaflet of the membrane to the cytosolic leaflet in the trans-Golgi network, overview
Saccharomyces cerevisiae
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
7.6.2.1
Golgi membrane
-
Saccharomyces cerevisiae
139
-
Metals/Ions
EC Number
Metals/Ions
Commentary
Organism
Structure
7.6.2.1
Mg2+
-
Saccharomyces cerevisiae
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
7.6.2.1
ATP + H2O + phosphatidylethanolamine/out
Saccharomyces cerevisiae
transport from the luminal leaflet of the membrane to the cytosolic leaflet
ADP + phosphate + phosphatidylethanolamine/in
-
-
?
7.6.2.1
ATP + H2O + phosphatidylserine/out
Saccharomyces cerevisiae
transport from the luminal leaflet of the membrane to the cytosolic leaflet
ADP + phosphate + phosphatidylserine/in
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
7.6.2.1
Saccharomyces cerevisiae
-
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
7.6.2.1
ATP + H2O + phosphatidylethanolamine/out
transport from the luminal leaflet of the membrane to the cytosolic leaflet
670656
Saccharomyces cerevisiae
ADP + phosphate + phosphatidylethanolamine/in
-
-
-
?
7.6.2.1
ATP + H2O + phosphatidylethanolamine/out
7-nitro-2-1,3-benzoxadiazol-4-yl-fluorescent-labeled substrate, transport from the luminal leaflet of the membrane to the cytosolic leaflet
670656
Saccharomyces cerevisiae
ADP + phosphate + phosphatidylethanolamine/in
-
-
-
?
7.6.2.1
ATP + H2O + phosphatidylserine/out
transport from the luminal leaflet of the membrane to the cytosolic leaflet
670656
Saccharomyces cerevisiae
ADP + phosphate + phosphatidylserine/in
-
-
-
?
7.6.2.1
ATP + H2O + phosphatidylserine/out
7-nitro-2-1,3-benzoxadiazol-4-yl-fluorescent-labeled substrate, transport from the luminal leaflet of the membrane to the cytosolic leaflet
670656
Saccharomyces cerevisiae
ADP + phosphate + phosphatidylserine/in
-
-
-
?
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
7.6.2.1
protein Drs2p
coupled to the enzyme, required for the translocation of phospholipids from the luminal leaflet of the membrane to the cytosolic leaflet in the trans-Golgi network, overview
Saccharomyces cerevisiae
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
7.6.2.1
Golgi membrane
-
Saccharomyces cerevisiae
139
-
Metals/Ions (protein specific)
EC Number
Metals/Ions
Commentary
Organism
Structure
7.6.2.1
Mg2+
-
Saccharomyces cerevisiae
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
7.6.2.1
ATP + H2O + phosphatidylethanolamine/out
Saccharomyces cerevisiae
transport from the luminal leaflet of the membrane to the cytosolic leaflet
ADP + phosphate + phosphatidylethanolamine/in
-
-
?
7.6.2.1
ATP + H2O + phosphatidylserine/out
Saccharomyces cerevisiae
transport from the luminal leaflet of the membrane to the cytosolic leaflet
ADP + phosphate + phosphatidylserine/in
-
-
?
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
7.6.2.1
ATP + H2O + phosphatidylethanolamine/out
transport from the luminal leaflet of the membrane to the cytosolic leaflet
670656
Saccharomyces cerevisiae
ADP + phosphate + phosphatidylethanolamine/in
-
-
-
?
7.6.2.1
ATP + H2O + phosphatidylethanolamine/out
7-nitro-2-1,3-benzoxadiazol-4-yl-fluorescent-labeled substrate, transport from the luminal leaflet of the membrane to the cytosolic leaflet
670656
Saccharomyces cerevisiae
ADP + phosphate + phosphatidylethanolamine/in
-
-
-
?
7.6.2.1
ATP + H2O + phosphatidylserine/out
transport from the luminal leaflet of the membrane to the cytosolic leaflet
670656
Saccharomyces cerevisiae
ADP + phosphate + phosphatidylserine/in
-
-
-
?
7.6.2.1
ATP + H2O + phosphatidylserine/out
7-nitro-2-1,3-benzoxadiazol-4-yl-fluorescent-labeled substrate, transport from the luminal leaflet of the membrane to the cytosolic leaflet
670656
Saccharomyces cerevisiae
ADP + phosphate + phosphatidylserine/in
-
-
-
?