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Literature summary extracted from

  • Sasaki, H.; Kojima, M.; Sawano, Y.; Kubota, K.; Suganuma, M.; Muramatsu, T.; Takahashi, K.; Tanokura, M.
    A proposed catalytic mechanism of aspergilloglutamic peptidase from Aspergillus niger (2005), Proc. Jpn. Acad. Ser. B, 81, 441-446.
No PubMed abstract available

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.23.19 extracellular the enzyme is secreted Aspergillus niger var. macrosporus
-
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.23.19 Aspergillus niger var. macrosporus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.23.19 native extracellular enzyme from culture medium Aspergillus niger var. macrosporus

Reaction

EC Number Reaction Comment Organism Reaction ID
3.4.23.19 preferential cleavage in B chain of insulin: Asn3-/-Gln, Gly13-/-Ala, Tyr26-/-Thr catalytic residues are GluB110 and GluB24, detailed catalytic mechanism, overview Aspergillus niger var. macrosporus
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.23.19 angiotensin II + H2O
-
 Aspergillus niger var. macrosporus DRVYIH + Pro-Phe
-
 ?
3.4.23.19 additional information substrate specificity Aspergillus niger var. macrosporus ?
-
 ?
3.4.23.19 substance P + H2O
-
 Aspergillus niger var. macrosporus RPKPQQFF + Gly-Leu-Met
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.23.19 AGP
-
 Aspergillus niger var. macrosporus
3.4.23.19 aspergilloglutamic peptidase
-
 Aspergillus niger var. macrosporus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.23.19 30
-
 assay at Aspergillus niger var. macrosporus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.23.19 4 5
-
 Aspergillus niger var. macrosporus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.4.23.19 1.5 7 pH profile Aspergillus niger var. macrosporus