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Literature summary extracted from

  • Kiss, A.; Kowalski, J.; Melzig, M.F.
    Compounds from Epilobium angustifolium inhibit the specific metallopeptidases ACE, NEP and APN (2004), Planta Med., 70, 919-923.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.15.1 ellagic acid IC50: 0.4 mM Sus scrofa
3.4.15.1 hyperosid IC50: 0.2 mM Sus scrofa
3.4.15.1 isoquercitrin IC50: 0.3 mM Sus scrofa
3.4.15.1 lisinopril IC50: 1 nM Sus scrofa
3.4.15.1 additional information compounds from Epilobium angustifolium inhibit. Taking into account the role of these peptidase in prostate diseases, the results may partly support and explain the use of Epilobium extracts in folk medicine Sus scrofa
3.4.15.1 oenothein B IC50: 0.25 mM Sus scrofa
3.4.15.1 quercetin 3-O-(6''-galloyl)-galactoside IC50: 0.16 mM Sus scrofa
3.4.15.1 quercitrin IC50: 0.25 mM Sus scrofa
3.4.15.1 quercitrin glucuronide IC50: 0.2 mM Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
3.4.15.1 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.15.1 sperm
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.15.1 hippuryl-His-Leu + H2O
-
 Sus scrofa hippuric acid + His-Leu
-
 ?

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.4.15.1 0.000001
-
 IC50: 1 nM Sus scrofa lisinopril
3.4.15.1 0.16
-
 IC50: 0.16 mM Sus scrofa quercetin 3-O-(6''-galloyl)-galactoside
3.4.15.1 0.2
-
 IC50: 0.2 mM Sus scrofa hyperosid
3.4.15.1 0.2
-
 IC50: 0.2 mM Sus scrofa quercitrin glucuronide
3.4.15.1 0.25
-
 IC50: 0.25 mM Sus scrofa quercitrin
3.4.15.1 0.25
-
 IC50: 0.25 mM Sus scrofa oenothein B
3.4.15.1 0.3
-
 IC50: 0.3 mM Sus scrofa isoquercitrin
3.4.15.1 0.4
-
 IC50: 0.4 mM Sus scrofa ellagic acid