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Literature summary extracted from

  • Uefuji, H.; Tatsumi, Y.; Morimoto, M.; Kaothien-Nakayama, P.; Ogita, S.; Sano, H.
    Caffeine production in tobacco plants by simultaneous expression of three coffee N-methyltranferases and its potential as a pest repellant (2005), Plant Mol. Biol., 59, 221-227.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.1.1.158 agriculture expression of the caffeine biosynthesis enzymes in transgenic crop plants amay protect against the crop damaging larvae of pests Coffea arabica
2.1.1.159 agriculture expression of the caffeine biosynthesis enzymes in transgenic crop plants may protect against the crop damaging larvae of pests Coffea arabica
2.1.1.160 agriculture expression of the caffeine biosynthesis enzymes in transgenic crop plants may protect against the crop damaging larvae of pests Coffea arabica

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.1.158 isozyme XMT1, functional expression in transgenic Nicotiana tabacum plant leaves Coffea arabica
2.1.1.159 isozyme MXMT1, functional expression in transgenic Nicotiana tabacum plant leaves Coffea arabica
2.1.1.160 isozyme DXMT1, functional expression in transgenic Nicotiana tabacum plant leaves Coffea arabica

Protein Variants

EC Number Protein Variants Comment Organism
2.1.1.158 additional information transgenic Nicotiana tabacum plant leaves expressing all three enzymes required for the biosynthesis of caffeine are no longer eaten by the tobacco cutworm caterpillars, Spodoptera litura, overview Coffea arabica
2.1.1.159 additional information transgenic Nicotiana tabacum plant leaves expressing all three enzymes required for the biosynthesis of caffeine are no longer eaten by the tobacco cutworm caterpillars, Spodoptera litura, overview Coffea arabica
2.1.1.160 additional information transgenic Nicotiana tabacum plant leaves expressing all three enzymes required for the biosynthesis of caffeine are no longer eaten by the tobacco cutworm caterpillars, Spodoptera litura, overview Coffea arabica

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.158 S-adenosyl-L-methionine + xanthosine Coffea arabica
-
 S-adenosyl-L-homocysteine + 7-methylxanthosine
-
 ir
2.1.1.159 S-adenosyl-L-methionine + 7-methylxanthine Coffea arabica
-
 S-adenosyl-L-homocysteine + 3,7-dimethylxanthine i.e. theobromine ir
2.1.1.159 S-adenosyl-L-methionine + paraxanthine Coffea arabica
-
 S-adenosyl-L-homocysteine + 1,3,7-trimethylxanthine i.e. caffeine ir
2.1.1.160 S-adenosyl-L-methionine + 3,7-dimethylxanthine Coffea arabica
-
 S-adenosyl-L-homocysteine + 1,3,7-trimethylxanthine i.e. caffeine ir

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.158 Coffea arabica Q9AVK0 isozyme XMT1; isozyme XMT1
-
2.1.1.159 Coffea arabica Q9AVJ9 isozyme MXMT1; isozyme MXMT1
-
2.1.1.160 Coffea arabica Q8H0D2 isozyme DXMT1; isozyme DXMT1
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.158 S-adenosyl-L-methionine + xanthosine
-
 Coffea arabica S-adenosyl-L-homocysteine + 7-methylxanthosine
-
 ir
2.1.1.159 S-adenosyl-L-methionine + 7-methylxanthine
-
 Coffea arabica S-adenosyl-L-homocysteine + 3,7-dimethylxanthine i.e. theobromine ir
2.1.1.159 S-adenosyl-L-methionine + paraxanthine
-
 Coffea arabica S-adenosyl-L-homocysteine + 1,3,7-trimethylxanthine i.e. caffeine ir
2.1.1.160 S-adenosyl-L-methionine + 3,7-dimethylxanthine
-
 Coffea arabica S-adenosyl-L-homocysteine + 1,3,7-trimethylxanthine i.e. caffeine ir

Synonyms

EC Number Synonyms Comment Organism
2.1.1.158 XMT1
-
 Coffea arabica
2.1.1.159 MXMT1
-
 Coffea arabica
2.1.1.160 DXMT1
-
 Coffea arabica