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Literature summary extracted from

  • Kil, I.S.; Shin, S.W.; Yeo, H.S.; Lee, Y.S.; Park, J.W.
    Mitochondrial NADP+-dependent isocitrate dehydrogenase protects cadmium-induced apoptosis (2006), Mol. Pharmacol., 70, 1053-1061.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.42 Cd2+ coadministration with oxalomalate results in inhibition of enzyme and glutaredoxin and enhanced susceptibility to apoptosis Mus musculus
1.1.1.42 Cd2+ binds to C379 of enzyme, resulting in loss of activity and structural alterations. Loss of glutaredoxin activity in cells treated with Cd2+ is more pronounced when cells are transfected with enzyme antisense cDNA Sus scrofa
1.1.1.42 Oxalomalate competitive, coadministration with CD2+ results in inhibition of enzyme and glutaredoxin and enhanced susceptibility to apoptosis Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.42 mitochondrion
-
Mus musculus 5739
-
1.1.1.42 mitochondrion
-
Sus scrofa 5739
-

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.42 Mus musculus
-
-
-
1.1.1.42 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.42 heart
-
Mus musculus
-
1.1.1.42 heart
-
Sus scrofa
-