EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.5.4.12 | 2',3'-dihydro-2',3'-dideoxy-thymidine monophosphate | - |
Homo sapiens | |
3.5.4.12 | 3'-azido-2',3'-dideoxy-thymidine monophosphate | - |
Homo sapiens | |
3.5.4.12 | 5-fluoro-dUMP | - |
Homo sapiens | |
3.5.4.12 | beta-D-2',2'-difluorodeoxycytidine | competitive | Homo sapiens | |
3.5.4.12 | beta-L-2',3'-dideoxy-3'-thiacytidine monophosphate | slight inhibition | Homo sapiens | |
3.5.4.12 | beta-L-2',3'-dideoxy-5'-fluoro-3'-thiacytidine monophosphate | - |
Homo sapiens | |
3.5.4.12 | D-beta-2'-fluoro-5-methyl-arabinofuranosyluracil monophosphate | no inhibition by L-beta-2'-fluoro-5-methyl-arabinofuranosyluracil monophosphate | Homo sapiens | |
3.5.4.12 | dUMP | product inhibition | Homo sapiens | |
3.5.4.12 | additional information | inhibitory potency of pyrimidine phosphate analogues, overview | Homo sapiens | |
3.5.4.12 | TMP | - |
Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.5.4.12 | 0.022 | - |
dCMP | pH 7.5 | Homo sapiens |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
3.5.4.12 | Mg2+ | - |
Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.5.4.12 | dCMP + H2O | Homo sapiens | the enzyme is important in the de novo synthesis of thymidine nucleotides, and may also be involved in the metabolism of anticancer agents | dUMP + NH3 | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.5.4.12 | Homo sapiens | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
3.5.4.12 | native enzyme 60fold from Hep-G2 cells by adsorption chromatography | Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.5.4.12 | Hep-G2 cell | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.5.4.12 | beta-D-2',2'-difluorodeoxycytidine + H2O | - |
Homo sapiens | beta-D-2',2'-difluorodeoxyuridine + NH3 | - |
? | |
3.5.4.12 | dCMP + H2O | - |
Homo sapiens | dUMP + NH3 | - |
? | |
3.5.4.12 | dCMP + H2O | the enzyme is important in the de novo synthesis of thymidine nucleotides, and may also be involved in the metabolism of anticancer agents | Homo sapiens | dUMP + NH3 | - |
? | |
3.5.4.12 | additional information | substrate specificity with deoxycytidine analogue monophosphates, overview | Homo sapiens | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.5.4.12 | dCMP deaminase | - |
Homo sapiens |
3.5.4.12 | deoxycytidylate deaminase | - |
Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
3.5.4.12 | 7.5 | - |
assay at | Homo sapiens |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.5.4.12 | 0.0046 | - |
TMP | pH 7.5 | Homo sapiens | |
3.5.4.12 | 0.0103 | - |
D-beta-2'-fluoro-5-methyl-arabinofuranosyluracil monophosphate | pH 7.5 | Homo sapiens | |
3.5.4.12 | 0.0142 | - |
5-fluoro-dUMP | pH 7.5 | Homo sapiens | |
3.5.4.12 | 0.0257 | - |
dUMP | pH 7.5 | Homo sapiens | |
3.5.4.12 | 0.0367 | - |
3'-azido-2',3'-dideoxy-thymidine monophosphate | pH 7.5 | Homo sapiens | |
3.5.4.12 | 0.0394 | - |
2',3'-dihydro-2',3'-dideoxy-thymidine monophosphate | pH 7.5 | Homo sapiens |