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Literature summary extracted from

  • Luu-The, V.; Tremblay, P.; Labrie, F.
    Characterization of type 12 17beta-hydroxysteroid dehydrogenase, an isoform of type 3 17beta-hydroxysteroid dehydrogenase responsible for estradiol formation in women (2006), Mol. Endocrinol., 20, 437-443.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.51 overexpression of type 3 17beta-HSD in HEK-293 cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.51 additional information design, synthesis and in vitro evaluation of 4-androstene-3,17-dione/adenosine hybrid compounds as bisubstrate inhibitors of type 3 17beta-HSD, the bisubstrate inhibitors are less potent in intact cells than in homogenated cells, overview, the best inhibitors of that series are those bearing an alkyl side-chain spacer of 11 or 12 methylenes with inhibition of 69% and 78% at 1 mM Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.62 0.0035
-
 estrone type 12 17beta-hydroxysteroid dehydrogenase Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.51 additional information Homo sapiens the enzyme is an important therapeutic target for androgen-sensitive diseases, overview ?
-
 ?
1.1.1.62 estrone + NAD(P)H + H+ Homo sapiens type 12 17beta-hydroxysteroid dehydrogenase plays a role in estrogen formation. Type 12 17beta-hydroxysteroid dehydrogenase is the major estrogenic 17beta-HSD responsible for the conversion of estrone to estradiol in women, especially in the ovary, the predominant source of estrogens before menopause estradiol + NAD(P)+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.51 Homo sapiens
-
-
-
1.1.1.62 Homo sapiens Q53GQ0
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.62 HEK-293 cell stable expressing 17beta-HSD12 Homo sapiens
-
1.1.1.62 mammary gland
-
 Homo sapiens
-
1.1.1.62 ovary type 12 17beta-hydroxysteroid dehydrogenase is most highly expressed in ovary and mammary gland Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.51 4-androstene-3,17-dione + NADPH + H+ selective reduction at C17 Homo sapiens testosterone + NADP+
-
 ?
1.1.1.51 additional information the enzyme is an important therapeutic target for androgen-sensitive diseases, overview Homo sapiens ?
-
 ?
1.1.1.62 estrone + NAD(P)H + H+ type 12 17beta-hydroxysteroid dehydrogenase plays a role in estrogen formation. Type 12 17beta-hydroxysteroid dehydrogenase is the major estrogenic 17beta-HSD responsible for the conversion of estrone to estradiol in women, especially in the ovary, the predominant source of estrogens before menopause Homo sapiens estradiol + NAD(P)+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.51 17beta-HSD
-
 Homo sapiens
1.1.1.51 type 3 17beta-HSD
-
 Homo sapiens
1.1.1.51 type 3 17beta-hydroxysteroid dehydrogenase
-
 Homo sapiens
1.1.1.62 17beta-HSD12
-
 Homo sapiens
1.1.1.62 type 12 17beta-hydroxysteroid dehydrogenase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.51 NADPH
-
 Homo sapiens