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Literature summary extracted from

  • Piekorz, R.P.; Gingras, S.; Hoffmeyer, A.; Ihle, J.N.; Weinstein, Y.
    Regulation of progesterone levels during pregnancy and parturition by signal transducer and activator of transcription 5 and 20alpha-hydroxysteroid dehydrogenase (2005), Mol. Endocrinol., 19, 431-440.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.1.149 additional information enzyme expression is induced by interleukin-2 and interleukin-3 in thymocytes and bone marrow cells Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
1.1.1.149 additional information construction of gene disruption mutants by homologous recombination lacking enzyme expression and activity, the mutant female mice lack parturition on day 20 of pregnancy, overview Mus musculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.1.1.149 Mg2+
-
 Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.149 17alpha-hydroxyprogesterone + NAD(P)H Mus musculus regulation of enzyme expression during pregnancy, the enzyme is required for prostaglandin F2alpha-dependent progesterone down-regulation before parturition, overview 17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.149 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.149 adrenal gland high expression level Mus musculus
-
1.1.1.149 bone marrow high expression level Mus musculus
-
1.1.1.149 kidney high expression level Mus musculus
-
1.1.1.149 ovary high expression level Mus musculus
-
1.1.1.149 thymus high expression level Mus musculus
-
1.1.1.149 uterus regulation of enzyme expression during pregnancy Mus musculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.149 additional information
-
 quantification of serum progesterone levels Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.149 17alpha-hydroxyprogesterone + NAD(P)H
-
 Mus musculus 17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+
-
 r
1.1.1.149 17alpha-hydroxyprogesterone + NAD(P)H regulation of enzyme expression during pregnancy, the enzyme is required for prostaglandin F2alpha-dependent progesterone down-regulation before parturition, overview Mus musculus 17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.1.1.149 20alpha-HSD
-
 Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.149 37
-
 assay at Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.149 7.4
-
 assay at Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.149 NAD(P)+
-
 Mus musculus
1.1.1.149 NAD(P)H
-
 Mus musculus