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Literature summary extracted from

  • Ngatcha, B.T.; Laplante, Y.; Labrie, F.; Luu-The, V.; Poirier, D.
    3beta-Alkyl-androsterones as inhibitors of type 3 17beta-hydroxysteroid dehydrogenase: inhibitory potency in intact cells, selectivity towards isoforms 1, 2, 5 and 7, binding affinity for steroid receptors, and proliferative/antiproliferative activities on AR+ and ER+ cell lines (2006), Mol. Cell. Endocrinol., 248, 225-232.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.51 3beta-cyclohexylethyl-androsterone
-
 Homo sapiens
1.1.1.51 3beta-hexyl-androsterone
-
 Homo sapiens
1.1.1.51 3beta-phenyl-androsterone mixed-type inhibition, shows some proliferative activity on AR+ and Er+ cell lines not mediated through androgen or estrogen receptors Homo sapiens
1.1.1.51 3beta-phenylethyl-androsterone
-
 Homo sapiens
1.1.1.51 3beta-phenylmethyl-androsterone mixed-type inhibition, shows some proliferative activity on AR+ and Er+ cell lines not mediated through androgen or estrogen receptors Homo sapiens
1.1.1.239 3beta-cyclohexylethyl-androsterone potent inhibitor Homo sapiens
1.1.1.239 3beta-n-hexyl-androsterone potent inhibitor Homo sapiens
1.1.1.239 3beta-phenylethyl-androsterone potent inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.51 androst-4-ene-3,17-dione + NADPH Homo sapiens
-
 testosterone + NADP+
-
 ?
1.1.1.239 androst-4-ene-3beta,17beta-diol + NAD+ Homo sapiens
-
 androst-4-ene-3beta-ol-17-one + NADH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.51 Homo sapiens
-
-
-
1.1.1.239 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.239 HEK-293 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.51 androst-4-ene-3,17-dione + NADPH
-
 Homo sapiens testosterone + NADP+
-
 ?
1.1.1.239 androst-4-ene-3beta,17beta-diol + NAD+
-
 Homo sapiens androst-4-ene-3beta-ol-17-one + NADH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.51 17beta-HSD
-
 Homo sapiens
1.1.1.51 type 3 17beta-hydroxysteroid dehydrogenase
-
 Homo sapiens
1.1.1.239 type 3 17beta-hydroxysteroid dehydrogenase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.51 NADPH
-
 Homo sapiens