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Literature summary extracted from

  • Conners, R.; Schambach, F.; Read, J.; Cameron, A.; Sessions, R.B.; Vivas, L.; Easton, A.; Croft, S.L.; Brady, R.L.
    Mapping the binding site for gossypol-like inhibitors of Plasmodium falciparum lactate dehydrogenase (2005), Mol. Biochem. Parasitol., 142, 137-148.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.1.1.27 crystals the apo-form of PfLDH are ontained by hanging-drop method with 2-methyl-2,4-pentanediol as precipitant, crystallization of enzyme:naphthoic acid complexes with 2,6-naphthalenedicarboxalic acid, 2,6-naphthalene disulfonic acid or 3,7-dihydroxy naphthalene-2-carboxylic acid and 3,7-dihydroxy naphthalene-2-carboxylic acid plus NAD+ Plasmodium falciparum

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.27 1,6-dibromo-2-hydroxynaphthalene 3-carboxylic acid 0.31 mM Plasmodium falciparum
1.1.1.27 2,6-naphthalene disulfonic acid IC50: 21 mM Plasmodium falciparum
1.1.1.27 2,6-naphthalenedicarboxalic acid IC50: 5.1 mM Plasmodium falciparum
1.1.1.27 3,5-dihydroxy 2-naphthoic acid IC50: 1.7 mM Plasmodium falciparum
1.1.1.27 3,7-dihydroxy naphthalene-2-carboxylic acid IC50: 2.4 mM Plasmodium falciparum
1.1.1.27 6,6'-Dithiodinicotinic acid IC50: 6.6 mM Plasmodium falciparum
1.1.1.27 8-anilino-1-naphthalene sulfonic acid IC50: 0.52 mM Plasmodium falciparum
1.1.1.27 Chloroquine IC50: 5.5 mM Plasmodium falciparum

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.27 Plasmodium falciparum
-
-
-

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.1.1.27 0.52
-
 IC50: 0.52 mM Plasmodium falciparum 8-anilino-1-naphthalene sulfonic acid
1.1.1.27 1.7
-
 IC50: 1.7 mM Plasmodium falciparum 3,5-dihydroxy 2-naphthoic acid
1.1.1.27 2.4
-
 IC50: 2.4 mM Plasmodium falciparum 3,7-dihydroxy naphthalene-2-carboxylic acid
1.1.1.27 5.1
-
 IC50: 5.1 mM Plasmodium falciparum 2,6-naphthalenedicarboxalic acid
1.1.1.27 5.5
-
 IC50: 5.5 mM Plasmodium falciparum Chloroquine
1.1.1.27 6.6
-
 IC50: 6.6 mM Plasmodium falciparum 6,6'-Dithiodinicotinic acid
1.1.1.27 21
-
 IC50: 21 mM Plasmodium falciparum 2,6-naphthalene disulfonic acid