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Literature summary extracted from

  • Durocher, F.; Sanchez, R.; Ricketts, M.L.; Labrie, Y.; Laudet, V.; Simard, J.
    Characterization of the guinea pig 3beta-hydroxysteroid dehydrogenase/DELTA5-DELTA4-isomerase expressed in the adrenal gland and gonads (2005), J. Steroid Biochem. Mol. Biol., 97, 289-298.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.51 DNA and amino acid sequence determination and analysis, phylogenetic analysis Cavia porcellus
1.1.1.145 cloning of the cDNA encoding 3beta-HSD from an adrenal library, DNA and amino acid sequence determination and analysis, phylogenetic analysis Cavia porcellus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.51 41475
-
x * 41475, amino acid sequence calculation Cavia porcellus

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.51 Cavia porcellus
-
-
-
1.1.1.145 Cavia porcellus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.51 adrenal gland
-
Cavia porcellus
-
1.1.1.51 gonad
-
Cavia porcellus
-
1.1.1.51 ovary
-
Cavia porcellus
-
1.1.1.51 testis
-
Cavia porcellus
-
1.1.1.145 adrenal gland
-
Cavia porcellus
-
1.1.1.145 gonad
-
Cavia porcellus
-
1.1.1.145 ovary
-
Cavia porcellus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.51 dehydroepiandrosterone + NADPH + H+ reduction at C17 Cavia porcellus 5-androstene-3beta,17beta-diol + NADP+
-
?
1.1.1.51 pregnenolone + NADPH
-
Cavia porcellus progesterone + NADP+
-
?
1.1.1.145 dehydroepiandrosterone + NAD+
-
Cavia porcellus ?
-
?
1.1.1.145 additional information trifunctional enzyme that also catalyzes the reaction of the DELTA-5-3-ketosteroid isomerase, EC 5.3.3.1, and of the 17beta-hydroxysteroid dehydrogenase type II, EC 1.1.1.51 Cavia porcellus ?
-
?
1.1.1.145 pregnenolone + NAD+
-
Cavia porcellus progesterone + NADH + H+
-
?

Subunits

EC Number Subunits Comment Organism
1.1.1.51 ? x * 41475, amino acid sequence calculation Cavia porcellus

Synonyms

EC Number Synonyms Comment Organism
1.1.1.51 17beta-HSD type II
-
Cavia porcellus
1.1.1.51 3beta-HSD
-
Cavia porcellus
1.1.1.51 3beta-hydroxysteroid dehydrogenase/DELTA5-DELTA4-isomerase
-
Cavia porcellus
1.1.1.145 3beta-HSD
-
Cavia porcellus
1.1.1.145 3beta-hydroxysteroid dehydrogenase/DELTA5-DELTA4-isomerase
-
Cavia porcellus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.51 NADPH
-
Cavia porcellus
1.1.1.145 NAD+
-
Cavia porcellus